Search Results - "Accardi, Luisa"
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Targeting Human Papillomavirus-Associated Cancer by Oncoprotein-Specific Recombinant Antibodies
Published in International journal of molecular sciences (01-09-2021)“…In recent decades, recombinant antibodies against specific antigens have shown great promise for the therapy of infectious diseases and cancer. Human…”
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Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors
Published in Journal of experimental & clinical cancer research (23-01-2021)“…The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral…”
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Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series
Published in Infectious agents and cancer (02-06-2023)“…This report covers the case of 7 women affected by pathologies related to genital Herpesvirus and Papillomavirus. They were referred to the gynaecology…”
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Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity
Published in BMC biotechnology (05-09-2019)“…Ebola hemorrhagic fever is caused by the Ebola filovirus (EBOV), which is one of the most aggressive infectious agents known worldwide. The EBOV pathogenesis…”
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Mucosal and cutaneous human papillomaviruses detected in raw sewages
Published in PloS one (14-01-2013)“…Epitheliotropic viruses can find their way into sewage. The aim of the present study was to investigate the occurrence, distribution, and genetic diversity of…”
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Prevalence of 13 polyomaviruses in actinic keratosis and matched healthy skin samples of immunocompetent individuals
Published in Infectious agents and cancer (01-12-2022)“…Actinic keratosis (AK) is a precursor of cutaneous squamous cell carcinoma (cSCC). UV radiation is the major risk factor for AK, but certain human…”
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The E6 and E7 proteins of beta3 human papillomavirus 49 can deregulate both cellular and extracellular vesicles-carried microRNAs
Published in Infectious agents and cancer (15-06-2022)“…The β3 human papillomavirus (HPV)49 induces immortalization of primary keratinocytes through the action of E6 and E7 oncoproteins with an efficiency similar to…”
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In vivo antitumor effect of an intracellular single‐chain antibody fragment against the E7 oncoprotein of human papillomavirus 16
Published in International journal of cancer (01-06-2014)“…Human papillomavirus (HPV)‐associated tumors still represent an urgent problem of public health in spite of the efficacy of the prophylactic HPV vaccines…”
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MicroRNAs Differentially Expressed in Actinic Keratosis and Healthy Skin Scrapings
Published in Biomedicines (01-06-2023)“…Actinic keratosis (AK) is a carcinoma in situ precursor of cutaneous squamous cell carcinoma (cSCC), the second most common cancer affecting the Caucasian…”
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Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer
Published in American journal of clinical pathology (01-07-2005)“…We analyzed survivin as a marker of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HR-HPV) and a predictor of HPV clearance and…”
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Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells
Published in BMC cancer (17-01-2011)“…"High risk" human papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. In these tumors, the physical…”
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Characterization of antibodies in single-chain format against the E7 oncoprotein of the human papillomavirus type 16 and their improvement by mutagenesis
Published in BMC cancer (31-01-2007)“…Human papillomaviruses (HPV) are the etiological agents of cervical cancer. The viral E7 protein plays a crucial role in viral oncogenesis. Many strategies…”
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Serum antibody response to Human papillomavirus (HPV) infections detected by a novel ELISA technique based on denatured recombinant HPV16 L1, L2, E4, E6 and E7 proteins
Published in Infectious agents and cancer (08-11-2006)“…Human papillomaviruses (HPVs) are the primary etiological agents of cervical cancer and are also involved in the development of other tumours (skin, head and…”
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Anti-Cancer Vaccine for HPV-Associated Neoplasms: Focus on a Therapeutic HPV Vaccine Based on a Novel Tumor Antigen Delivery Method Using Endogenously Engineered Exosomes
Published in Cancers (24-01-2019)“…Some human papillomavirus (HPV) genotypes are universally recognized as major etiological agents not only of ano-genital tumors but also of head and neck…”
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Clinical and epidemiological correlates of antibody response to human papillomaviruses (HPVs) as measured by a novel ELISA based on denatured recombinant HPV16 late (L) and early (E) antigens
Published in Infectious agents and cancer (26-06-2008)“…At present, seroreactivity is not a valuable parameter for diagnosis of Human Papillomavirus (HPV) infection but, it is potentially valuable as marker of viral…”
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Epitope Mapping and Computational Analysis of Anti-HPV16 E6 and E7 Antibodies in Single-Chain Format for Clinical Development as Antitumor Drugs
Published in Cancers (06-07-2020)“…Human Papillomavirus 16-associated cancer, affecting primarily the uterine cervix but, increasingly, other body districts, including the head–neck area, will…”
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A large spectrum of alpha and beta papillomaviruses are detected in human stool samples
Published in Journal of general virology (01-03-2015)“…Human papillomaviruses (HPVs) have been detected in urban wastewaters, demonstrating that epitheliotropic viruses can find their way into sewage through the…”
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The Intracellular Delivery Of Anti-HPVI6 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells
Published in International journal of nanomedicine (01-11-2019)“…Purpose: Single-chain variable fragments (scFvs) are one of the smallest antigen-binding units having the invaluable advantage to be expressed by a unique…”
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The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells
Published in International journal of nanomedicine (01-01-2019)“…Single-chain variable fragments (scFvs) are one of the smallest antigen-binding units having the invaluable advantage to be expressed by a unique short open…”
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Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears
Published in Infection, genetics and evolution (01-03-2019)“…Sequence analysis of HPV16 isolates reveals the presence of genome variants with characteristic mutations. The HPV16 variants have different geographical…”
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