Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka

Background: As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak. Methods: SARS-CoV-2 serop...

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Published in:	Frontiers in public health Vol. 9; p. 724398
Main Authors:	Jeewandara, Chandima, Guruge, Dinuka, Abyrathna, Inoka Sepali, Danasekara, Saubhagya, Gunasekera, Banuri, Pushpakumara, Pradeep Darshana, Madhusanka, Deshan, Jayathilaka, Deshni, Ranasinghe, Thushali, Somathilake, Gayasha, Tanussiya, Shyrar, Jayadas, Tibutius Tanesh, Kuruppu, Heshan, Thashmi, Nimasha, Harvie, Michael, Wijayamuni, Ruwan, Schimanski, Lisa, Tan, T. K., Rijal, Pramila, Xiao, Julie, Ogg, Graham S., Townsend, Alain, Malavige, Gathsaurie Neelika
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 12-11-2021
Subjects:	antibodies Colombo Public Health SARS-CoV-2 seropositivity serosurveillance Sri Lanka
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Summary:	Background: As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak. Methods: SARS-CoV-2 seropositivity was determined in 2,547 individuals between the ages of 10–86 years, by the Wantai total antibody ELISA. We also compared seroprevalence using the haemagglutination test (HAT) to evaluate its usefulness in carrying out serosurveys. Results: The overall seropositivity rate was 24.46%, while seropositivity by HAT was 18.90%. Although The SARS-CoV-2 infection detection rates by PCR were highest in the population between the ages of 20–60 years of age, there was no statistically significant difference in the seropositivity rates in different age groups. For instance, although the seropositivity rate was highest in the 10–20 age group (34.03%), the PCR positivity rate was 9.80%. Differences in the PCR positivity rates and seropositivity rates were also seen in 60–70-year-olds (8.90 vs. 30.4%) and in individuals >70 years (4.10 vs. 1.20%). The seropositivity rate of the females was 29.70% (290/976), which was significantly higher ( p < 0.002) than in males 21.2% (333/1,571). Conclusions: A high seroprevalence rate (24.5%) was seen in all age groups in the CMC suggesting that a high level of transmission was seen during this time. The higher PCR positivity rates between the ages of 20–60 are likely to be due to increased testing carried out in the working population. Therefore, the PCR positivity rates, appear to underestimate the true extent of the outbreak and the age groups which were infected.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Infectious Diseases - Surveillance, Prevention and Treatment, a section of the journal Frontiers in Public Health These authors have contributed equally to this work Edited by: Walid Alali, Kuwait University, Kuwait Reviewed by: Ralf J. Braun, Danube Private University, Austria; Inaamul Haq, Government Medical College (GMC), India
ISSN:	2296-2565 2296-2565
DOI:	10.3389/fpubh.2021.724398