Genome Sequencing Variations in the Octodon degus , an Unconventional Natural Model of Aging and Alzheimer's Disease

Genome Sequencing Variations in the Octodon degus , an Unconventional Natural Model of Aging and Alzheimer's Disease

The degu ( ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuro...

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Published in:Frontiers in aging neuroscience Vol. 14; p. 894994
Main Authors: Hurley, Michael J, Urra, Claudio, Garduno, B Maximiliano, Bruno, Agostino, Kimbell, Allison, Wilkinson, Brent, Marino-Buslje, Cristina, Ezquer, Marcelo, Ezquer, Fernando, Aburto, Pedro F, Poulin, Elie, Vasquez, Rodrigo A, Deacon, Robert, Avila, Ariel, Altimiras, Francisco, Whitney Vanderklish, Peter, Zampieri, Guido, Angione, Claudio, Constantino, Gabriele, Holmes, Todd C, Coba, Marcelo P, Xu, Xiangmin, Cogram, Patricia
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 30-06-2022
Frontiers Media S.A
Subjects:
Adaptation
Aging
Aging Neuroscience
Alzheimer's disease
Amino acids
amyloids
Animal models
APOE
Apolipoprotein E
Arteriosclerosis
Cataracts
Circadian rhythms
Cognitive ability
Diabetes mellitus
Gene expression
Genetic engineering
genome
Genomes
Inflammation
Laboratory animals
lipid droplets
Macular degeneration
Medical research
Mutation
Neurodegeneration
Neurodegenerative diseases
Octodon degus
Ontology
Pathology
Protein structure
Senile plaques
Single-nucleotide polymorphism
Tau protein
Whole genome sequencing
United States > US
amyloids
genome
drug development
Octodon degus
APOE
aging
lipid droplets
Alzheimer's disease
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Summary:The degu ( ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E ( ) gene variant that correlated with an increase in amyloid plaques in brain and modified the predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.
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content type line 23
These authors share senior authorship
This article was submitted to Alzheimer's Disease and Related Dementias, a section of the journal Frontiers in Aging Neuroscience
Edited by: Allison B. Reiss, New York University, United States
Reviewed by: Nobuyuki Kimura, Okayama University of Science, Japan; Carsten Korth, Heinrich Heine University of Düsseldorf, Germany
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.894994