Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed to investigate serum levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), and endothe...

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Published in:	Journal of international medical research Vol. 48; no. 4; p. 300060519893858
Main Authors:	Hegazy, Gehan A, Awan, Zuhier, Hashem, Enayat, Al-Ama, Nabil, Abunaji, Asmaa Basha
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-04-2020 Sage Publications Ltd SAGE Publishing
Subjects:	Cardiovascular disease Cardiovascular Diseases - complications Cell adhesion & migration Cell Adhesion Molecules Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - complications E-Selectin - blood Humans Intercellular Adhesion Molecule-1 - blood Retrospective Clinical Research Report Vascular Cell Adhesion Molecule-1 - blood sE-selectin diabetes mellitus Cardiovascular diseases macrovascular complications vascular cell adhesion molecule-1 intercellular adhesion molecule-1
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Summary:	Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed to investigate serum levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), and endothelium selectin (sE-selectin) in T2DM patients with macrovascular complications. Methods A cross-sectional study of 21 controls, 30 T2DM patients without CVDs, and 30 T2DM patients with CVDs was conducted. Serum levels of soluble adhesion molecules including sVCAM-1, sICAM-1, and sE-selectin were determined using ELISA. Results Serum levels of sVCAM-1, sICAM-1, and sE-selectin were higher in T2DM patients than in controls. Levels of serum sVCAM-1 were higher in T2DM patients with CVDs compared with T2DM patients without CVDs. In T2DM patients with CVDs, significant positive associations were observed between sVCAM-1, sICAM-1, and sE-selectin levels (r = 0.575, p = 0.001 and r = 0.378, p = 0.040). Conclusions Circulating levels of soluble adhesion molecules were elevated in T2DM patients, regardless of whether the patients had cardiovascular complications. Only sVCAM-1 was considered a useful marker for the prediction of CVDs in T2DM patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0300-0605 1473-2300
DOI:	10.1177/0300060519893858