Cell cycle regulators and bone: development and regeneration

Cell cycle regulators and bone: development and regeneration

Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in differentiation, apoptosis, senescence, and other cell processes. Emerging evidence has demonstrated a role for cell cycle regulators in bone healing/dev...

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Bibliographic Details
Published in:Cell & bioscience Vol. 13; no. 1; p. 35
Main Authors: Shaikh, Alisha, Wesner, Austin A, Abuhattab, Mohanad, Kutty, Raman G, Premnath, Priyatha
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 21-02-2023
BioMed Central
BMC
Subjects:
Apoptosis
Blood vessels
Bone
Bone growth
Bone healing
Bone marrow
Bone mineral density
Bones
Cartilage
Cell cycle
Cell differentiation
Cell division
Chondrocytes
Clonal deletion
Cytokines
Density
Extracellular matrix
Fractures
Osteoclasts
Osteogenesis
Osteoporosis
p21
Proteins
Regeneration
Review
Senescence
Tibia
Wound healing
Regeneration
Bone
p21
Cell cycle
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Summary:Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in differentiation, apoptosis, senescence, and other cell processes. Emerging evidence has demonstrated a role for cell cycle regulators in bone healing/development cascade. We demonstrated that deletion of p21, a cell cycle regulator acting at the G1/S transition enhanced bone repair capacity after a burr-hole injury in the proximal tibia of mice. Similarly, another study has shown that inhibition of p27 can increase bone mineral density and bone formation. Here, we provide a concise review of cell cycle regulators that influence cells like osteoblasts, osteoclasts, and chondrocytes, during development and/or healing of bone. It is imperative to understand the regulatory processes that govern cell cycle during bone healing and development as this will pave the way to develop novel therapies to improve bone healing after injury in instances of aged or osteoporotic fractures.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-023-00988-7