Search Results - "Abuelizz, Hatem A"
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Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study
Published in PloS one (14-08-2019)“…Previously, we synthesized triazoloquinazolines 1-14 and characterized their structure. In this study, we aimed to evaluate the in vitro activity of the…”
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2
Synthesis and anticancer activity of new quinazoline derivatives
Published in Saudi pharmaceutical journal (01-11-2017)“…In this study, a new series of quinazoline derivatives (3–26) was synthesized and characterized via physicochemical and spectral means. Treatment of…”
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3
Reactivity of 4,5-Dichlorophthalic Anhydride towards Thiosemicarbazide and Amines: Synthesis, Spectroscopic Analysis, and DFT Study
Published in Molecules (Basel, Switzerland) (31-05-2022)“…The cyclic anhydrides are broadly employed in several fields, such as the chemical, plastic, agrochemical, and pharmaceutical industries. This study describes…”
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Synthesis of High-Purity Hydroxyapatite and Phosphoric Acid Derived from Moroccan Natural Phosphate Rocks by Minimizing Cation Content Using Dissolution-Precipitation Technique
Published in Molecules (Basel, Switzerland) (14-08-2024)“…This study investigates, in the first part, the synthesis and purification of a poorly crystalline hydroxyapatite (HAp) using natural Moroccan phosphate…”
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Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[ g ]quinazoline Derivatives (In Vitro)
Published in Molecules (Basel, Switzerland) (15-12-2020)“…A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[ ]quinazolines ( - ) were synthesized, characterized, and evaluated in vitro for their antiangiogenesis…”
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6
Fabrication and In Vitro Biological Assay of Thermo-Mechanically Tuned Chitosan Reinforced Polyurethane Composites
Published in Molecules (Basel, Switzerland) (01-10-2023)“…The progressive trend of utilizing bioactive materials constitutes diverse materials exhibiting biocompatibility. The innovative aspect of this research is the…”
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Hirshfeld Surface Analysis and Density Functional Theory Calculations of 2-Benzyloxy-1,2,4-triazolo[1,5-a] quinazolin-5(4H)-one: A Comprehensive Study on Crystal Structure, Intermolecular Interactions, and Electronic Properties
Published in Crystals (Basel) (01-10-2023)“…This study employs a comprehensive computational analysis of the 2-benzyloxy-1,2,4-triazolo[1,5-a] quinazolin-5(4H)-one (ID code: CCDC 834498) to explore its…”
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8
Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives
Published in Molecules (Basel, Switzerland) (30-06-2017)“…A new series of quinazoline-4(3H)-ones are evaluated for anticonvulsant activity. After intraperitoneal (ip) injection to albino mice at a dose of 100 mg/kg…”
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A DFT Study and Hirshfeld Surface Analysis of the Molecular Structures, Radical Scavenging Abilities and ADMET Properties of 2-Methylthio(methylsulfonyl)-[1,2,4]triazolo [1,5-a]quinazolines: Guidance for Antioxidant Drug Design
Published in Crystals (Basel) (01-07-2023)“…Optimisation at B3LYP/6-311G(d,p) was used in a DFT study of the characteristics of 2-methylthio(methylsulfonyl)-triazoloquinazolines (1, 2). The…”
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10
Draft genome sequence of potato crop bacterial isolates and nanoparticles-intervention for the induction of secondary metabolites biosynthesis
Published in Saudi pharmaceutical journal (01-06-2023)“…Insights about the effects of gold nanoparticles (AuNPs) on the biosynthetic manipulation of unknown microbe secondary metabolites could be a promising…”
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11
Priestia megaterium Metabolism: Isolation, Identification of Naringenin Analogues and Genes Elevated Associated with Nanoparticle Intervention
Published in Current issues in molecular biology (14-08-2023)“…The impact of gold nanoparticles (AuNPs) on the biosynthetic manipulation of Priestia megaterium metabolism where an existing gene cluster is enhanced to…”
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Coriandrum sativum L., essential oil as a promising source of bioactive compounds with GC/MS, antioxidant, antimicrobial activities : in vitro and in silico predictions
Published in Frontiers in chemistry (20-06-2024)“…L. essential oil (CS-EO) is being evaluated for its antioxidant and antimicrobial properties, and its volatile compounds are to be identified as part of this…”
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13
Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies
Published in Molecules (Basel, Switzerland) (24-05-2018)“…A new series of 2-(5-methoxy-2-methyl-1 -indol-3-yl)- ′-[( )-(substituted phenyl) methylidene] acetohydrazide derivatives ( ⁻ ) were synthesized and evaluated…”
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14
Synthesis, Crystal Structure, and Computational Investigations of 2-(2-(4-Fluorophenyl)-2-oxoethyl)-6-methyl-5-(4-methylbenzyl)pyridazin-3(2H)-one as Antiviral Agent
Published in Crystals (Basel) (01-07-2023)“…The aim of this work was to scrutinize the physiochemical properties of a new pyridazin-3(2H)-one derivative with potential pharmaceutical effectiveness via…”
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Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2018)“…A new series of 4,6-disubstituted 2-(4-(dimethylamino)styryl)quinoline 4a,b-9a,b was synthesized by the reaction of 2-(4-(dimethylamino)styryl)-6-substituted…”
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16
Identifying factors and target preventive therapies for Middle East Respiratory Syndrome sucsibtable patients
Published in Saudi pharmaceutical journal (01-02-2020)“…Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a novel coronavirus that was identified in 2012 in Saudi Arabia. It is associated…”
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Benzo[g]quinazolines as antifungal against candidiasis: Screening, molecular docking, and QSAR investigations
Published in Saudi pharmaceutical journal (01-06-2023)“…Candida albicans, an opportunistic pathogen, is the most common type of fungus and represents a substantial source of human invasive disease (nosocomial…”
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Evaluation of Some Benzo[g]Quinazoline Derivatives as Antiviral Agents against Human Rotavirus Wa Strain: Biological Screening and Docking Study
Published in Current issues in molecular biology (01-03-2023)“…Globally, rotavirus (RV) is the most common cause of acute gastroenteritis in infants and toddlers; however, there are currently no agents available that are…”
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Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions
Published in Heliyon (30-04-2024)“…This exploratory study aims to identify the volatile compounds in PC-Eo (Petroselinum crispum L. essential oil) and evaluate its antioxidant and antimicrobial…”
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In Vitro and Reactive Metabolites Investigation of Metabolic Profiling of Tyrosine Kinase Inhibitors Dubermatinib in HLMs by LC–MS/MS
Published in Separations (01-06-2023)“…Dubermatinib (DMB, TP-0903), a benzenesulfonamide, is an inhibitor of the tyrosine kinase AXL, which is a member of the TAM family and can prevent…”
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