Search Results - "Abuchowski, Abe"

Pharmacologically increasing collateral perfusion during acute stroke using a carboxyhemoglobin gas transfer agent (Sanguinate™) in spontaneously hypertensive rats by Cipolla, Marilyn J, Linfante, Italo, Abuchowski, Abe, Jubin, Ronald, Chan, Siu-Lung

“…Similar to patients with chronic hypertension, spontaneously hypertensive rats (SHR) develop fast core progression during middle cerebral artery occlusion…”
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Effects of Sanguinate on Systemic and Microcirculatory Variables in a Model of Prolonged Hemorrhagic Shock by Nugent, William H, Cestero, Ramon F, Ward, Kevin, Jubin, Ronald, Abuchowski, Abe, Song, Bjorn K

“…BACKGROUND:Hemorrhage and its complications are the leading cause of preventable death from trauma in young adults, especially in remote locations. To address…”
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Improved Hemodynamic Recovery and 72-Hour Survival Following Low-Volume Resuscitation with a PEGylated Carboxyhemoglobin in a Rat Model of Severe Hemorrhagic Shock by Macko, Antoni, Sheppard, Forest R, Nugent, William H, Abuchowski, Abe, Song, Bjorn K

“…Abstract Introduction: Hemorrhage is a leading cause of death from potentially survivable civilian and military trauma. As projected conflicts move from…”
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Effects of Sanguinate ™ on Systemic and Microcirculatory Variables in a Model of Prolonged Ischemic Shock by Nugent, William H, Cestero, Ramon F, Jubin, Ronald, Abuchowski, Abe, Song, Bjorn K

“…Abstract only Hemorrhage after trauma is the leading cause of preventable death in young adults. In cases of severe blood loss, outcomes are dependent on…”
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Abstract 62: Sanguinate TM Opens Collaterals, Improves Reperfusion and Decreases Infarct in Hypertensive Rats by Cipolla, Marilyn, Linfante, Italo, Abuchowski, Abe, Jubin, Ronald, Chan, Siu-Lung

“…Abstract only Background: The PEGylated cell-free carboxyhemoglobin gas exchanger Sanguinate TM (SG) has multiple beneficial actions that may improve stroke…”
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Successful Use of Pegylated Carboxyhemoglobin Bovine As an Emergency Treatment for Severe Anemia in a Patient with Sickle Cell Disease and Hyperhemolysis: A Case Report by Nalley, Candice M, Abuchowski, Abe, Hsu, Steven, Lanzkron, Sophie

“…Introduction: Modern biotechnology has long sought the development of a safe and effective red cell alternative. For patients with sickle cell disease and…”
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Microvascular and Systemic Impact of Resuscitation with PEGylated Carboxyhemoglobin-Based Oxygen Carrier or Hetastarch in a Rat Model of Transient Hemorrhagic Shock by Nugent, William H., Sheppard, Forest R., Dubick, Michael A., Cestero, Ramon F., Darlington, Daniel N., Jubin, Ronald, Abuchowski, Abe, Song, Bjorn K.

“…BACKGROUND:Hemorrhage is the leading cause of preventable, traumatic death. Currently, prehospital resuscitation fluids provide preload but not oxygen-carrying…”
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Rapid Reversal of Red Blood Cell Sickling Promoted By Pegylated Carboxyhemoglobin Bovine Gas Transfer Properties by Jubin, Ronald, Buontempo, Peter, Yglesias, Ricardo A, Abuchowski, Abe, Chen, Yuli, Kazo, Glenn, Kazo, Friedericke

“…Background: Red blood cell (RBC) sickling is the hallmark phenotype of Sickle Cell Disease (SCD) resulting from an inherited hemoglobin (HbS) point mutation…”
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Infusion of Pegylated Bovine Carboxyhemoglobin (PEG-COHb) Is Associated with Rapid Reversal of Progressive Acute Chest Syndrome in a Jehovah's Witness Patient with Hemoglobin SC Sickle Cell Disease by Kato, Roberta Miyeko, Hofstra, Thomas, Meiselman, Herbert J., Forman, Henry Jay, Abuchowski, Abe, Parmar, Deven V., Coates, Thomas D.

“…Acute chest syndrome (ACS) is a potentially fatal complication of sickle cell disease (SCD) and is characterized by opacification of the chest x-ray (CXR) and…”
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Improvement in Angiogenesis and Restoration of Blood Flow in Diabetic Mice by SanguinateTM by Shen, Xiaoping, Rosario, Rosa, Zou, Yu Shan, Schmidt, Ann Marie, Abuchowski, Abe, Yan, Shi‐Fang

“…To improve angiogenesis and restoration of blood flow in diabetic mice subjected to hind limb ischemia, here we test the hypothesis that Sanguinate (PEG‐COHb),…”
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Improvement in Angiogenesis and Restoration of Blood Flow in Diabetic Mice by Sanguinate TM by Shen, Xiaoping, Rosario, Rosa, Zou, Yu Shan, Schmidt, Ann Marie, Abuchowski, Abe, Yan, Shi‐Fang

“…Abstract only…”
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PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model by Nho, K, Glower, D, Bredehoeft, S, Shankar, H, Shorr, R, Abuchowski, A

“…An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native…”
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