Search Results - "Abubakar, Zuroida"
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Calpastatin overexpression reduces oxidative stress-induced mitochondrial impairment and cell death in human neuroblastoma SH-SY5Y cells by decreasing calpain and calcineurin activation, induction of mitochondrial fission and destruction of mitochondrial fusion
Published in Mitochondrion (01-09-2016)“…Calpain is an intracellular Ca(2+)-dependent protease, and the activation of calpain has been implicated in neurodegenerative diseases. Calpain activity can be…”
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Methamphetamine toxicity-induced calcineurin activation, nuclear translocation of nuclear factor of activated T-cells and elevation of cyclooxygenase 2 levels are averted by calpastatin overexpression in neuroblastoma SH-SY5Y cells
Published in Neurotoxicology (Park Forest South) (01-07-2018)“…•Methamphetamine toxicity induces calcineurin activation.•Methamphetamine toxicity induces nuclear translocation of NFAT.•Methamphetamine toxicity induces…”
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Defective functions of HNF1A variants on BCL2L1 transactivation and beta-cell growth
Published in Biochemical and biophysical research communications (27-08-2020)“…Maturity-onset diabetes of the young type 3 (MODY3) is caused by mutations in a gene encoding transcription factor hepatocyte nuclear factor 1-alpha (HNF1A)…”
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Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia
Published in The journal of clinical endocrinology and metabolism (01-03-2022)“…Genes causing familial forms of diabetes mellitus are only partially known. We set out to identify the genetic cause of hyperglycemia in multigenerational…”
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Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells
Published in Molecular and cellular endocrinology (15-02-2021)“…Diabetes is a genetically heterogeneous disease, for which we are aiming to identify causative genes. Here, we report a missense mutation (c.T1424C:p.L475P) in…”
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