Search Results - "Abu Khweek, Arwa"

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Abdelaziz, Dalia H.A., Newland, Christie, Rosales-Reyes, Roberto, Kopp, Benjamin, McCoy, Karen, Montione, Richard, Schlesinger, Larry S., Gavrilin, Mikhail A., Wewers, Mark D., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis (CF) is the most common inherited lethal disease of Caucasians which results in multi organ dysfunction. However, 85% of the deaths are due to…”
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Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo by Estfanous, Shady, Krause, Kathrin, Anne, Midhun N. K., Eltobgy, Mostafa, Caution, Kyle, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Daily, Kylene, Carafice, Cierra, Baetzhold, Daniel, Zhang, Xiaoli, Li, Tianliang, Wen, Haitao, Gavrilin, Mikhail A., Haffez, Hesham, Soror, Sameh, Amer, Amal O.

“…Burkholderia cenocepacia ( B. cenocepacia ) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals…”
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Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia by Gavrilin, Mikhail A, Abdelaziz, Dalia H A, Mostafa, Mahmoud, Abdulrahman, Basant A, Grandhi, Jaykumar, Akhter, Anwari, Abu Khweek, Arwa, Aubert, Daniel F, Valvano, Miguel A, Wewers, Mark D, Amer, Amal O

“…Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis…”
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The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages by Abu Khweek, Arwa, Kanneganti, Apurva, Guttridge D, Denis C, Amer, Amal O

“…L. pneumophila is the causative agent of Legionnaires' disease, a human illness characterized by severe pneumonia. In contrast to those derived from humans,…”
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Peroxisome Proliferator-activated Receptors as Potential Targets for Carcinogenic Activity of Polychlorinated Biphenyls: A Computational Perspective by Sheikh, Ishfaq Ahmad, Khweek, Arwa Abu, Beg, Mohd Amin

“…Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer,…”
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Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes by Abdelaziz, Dalia H., Gavrilin, Mikhail A., Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Khweek, Arwa Abu, Abdulrahman, Basant A., Grandhi, Jaykumar, Hassan, Zeinab A., Marsh, Clay, Wewers, Mark D., Amer, Amal O.

“…The ability of Legionella pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their…”
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Pyroptotic and non‐pyroptotic effector functions of caspase‐11 by Abu Khweek, Arwa, Amer, Amal O.

“…Innate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury, thus mounting regulated immune response…”
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Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages by Kotrange, Sheetal, Kopp, Benjamin, Akhter, Anwari, Abdelaziz, Dalia, Abu Khweek, Arwa, Caution, Kyle, Abdulrahman, Basant, Wewers, Mark D., McCoy, Karen, Marsh, Clay, Loutet, Slade A., Ortega, Ximena, Valvano, Miguel A., Amer, Amal O.

“…B. cenocepacia O antigen, host TLR4 and caspase‐1 contribute to IL‐1β production by infected macrophage. Burkholderia cenocepacia infections in CF patients…”
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Factors Mediating Environmental Biofilm Formation by Legionella pneumophila by Abu Khweek, Arwa, Amer, Amal O

“…( ) is an opportunistic waterborne pathogen and the causative agent for Legionnaires' disease, which is transmitted to humans via inhalation of contaminated…”
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Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma by Abu Khweek, Arwa, Kim, Eunsoo, Joldrichsen, Marisa R, Amer, Amal O, Boyaka, Prosper N

“…The prevalence of asthma has been rising steadily for several decades, and continues to be a major public health and global economic burden due to both direct…”
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Caspase‐11 counteracts mitochondrial ROS‐mediated clearance of Staphylococcus aureus in macrophages by Krause, Kathrin, Daily, Kylene, Estfanous, Shady, Hamilton, Kaitlin, Badr, Asmaa, Abu Khweek, Arwa, Hegazi, Rana, Anne, Midhun NK, Klamer, Brett, Zhang, Xiaoli, Gavrilin, Mikhail A, Pancholi, Vijay, Amer, Amal O

“…Methicillin‐resistant Staphylococcus aureus (MRSA) is a growing health concern due to increasing resistance to antibiotics. As a facultative intracellular…”
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Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation by Caution, Kyle, Young, Nicholas, Robledo-Avila, Frank, Krause, Kathrin, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Vaidya, Anup, Daily, Kylene, Gosu, Hawin, Anne, Midhun N K, Eltobgy, Mostafa, Dakhlallah, Duaa, Argwal, Sudha, Estfanous, Shady, Zhang, Xiaoli, Partida-Sanchez, Santiago, Gavrilin, Mikhail A, Jarjour, Wael N, Amer, Amal O

“…Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses…”
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Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation by Estfanous, Shady, Daily, Kylene P, Eltobgy, Mostafa, Deems, Nicholas P, Anne, Midhun N K, Krause, Kathrin, Badr, Asmaa, Hamilton, Kaitlin, Carafice, Cierra, Hegazi, Ahmad, Abu Khweek, Arwa, Kelani, Hesham, Nimjee, Shahid, Awad, Hamdy, Zhang, Xiaoli, Cormet-Boyaka, Estelle, Haffez, Hesham, Soror, Sameh, Mikhail, Adel, Nuovo, Gerard, Barrientos, Ruth M, Gavrilin, Mikhail A, Amer, Amal O

“…Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer's Disease (AD), though mechanisms underlying this…”
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Caspase-11 regulates lung inflammation in response to house dust mites by Abu Khweek, Arwa, Joldrichsen, Marisa R., Kim, Eunsoo, Attia, Zayed, Krause, Kathrin, Daily, Kylene, Estfanous, Shady, Hamilton, Kaitlin, Badr, Asmaa, Anne, Midhun N.K., Eltobgy, Mostafa, Corps, Kara N, Carafice, Cierra, Zhang, Xiaoli, Gavrilin, Mikhail A., Boyaka, Prosper N., Amer, Amal O.

“…•House dust mite (HDM) induces caspase-11 expression by macrophages and this effect is enhanced by IL-4 and IL-13.•Bone marrow -derived macrophages of…”
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Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Tazi, Mia, Hassan, Hoda, Zhang, Yucheng, Rowland, Patrick D., Malhotra, Sankalp, Aeffner, Famke, Davis, Ian C., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator…”
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Defective immunometabolism pathways in cystic fibrosis macrophages by Hamilton, Kaitlin, Krause, Kathrin, Badr, Asmaa, Daily, Kylene, Estfanous, Shady, Eltobgy, Mostafa, Khweek, Arwa Abu, Anne, Midhun N.K., Carafice, Cierra, Baetzhold, Daniel, Tonniges, Jeffrey R., Zhang, Xiaoli, Gavrilin, Mikhail A., Parinandi, Narasimham L., Amer, Amal O.

“…•Mitochondria in CF macrophages are less capable of responding to energetic stress.•B. cenocepacia infection further exacerbates this mitochondrial defect.•CF…”
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CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages by Badr, Asmaa, Eltobgy, Mostafa, Krause, Kathrin, Hamilton, Kaitlin, Estfanous, Shady, Daily, Kylene P, Abu Khweek, Arwa, Hegazi, Ahmad, Anne, Midhun N K, Carafice, Cierra, Robledo-Avila, Frank, Saqr, Youssra, Zhang, Xiaoli, Bonfield, Tracey L, Gavrilin, Mikhail A, Partida-Sanchez, Santiago, Seveau, Stephanie, Cormet-Boyaka, Estelle, Amer, Amal O

“…Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as . The autophagy process in CF (F508del) macrophages…”
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Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo by Estfanous, Shady, Krause, Kathrin, Anne, Midhun N. K., Eltobgy, Mostafa, Caution, Kyle, Khweek, Arwa Abu, Hamilton, Kaitlin, Badr, Asmaa, Daily, Kylene, Carafice, Cierra, Baetzhold, Daniel, Zhang, Xiaoli, Li, Tianliang, Wen, Haitao, Gavrilin, Mikhail A., Haffez, Hesham, Soror, Sameh, Amer, Amal O.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages by Abu Khweek, Arwa, Fernández Dávila, Natalia S, Caution, Kyle, Akhter, Anwari, Abdulrahman, Basant A, Tazi, Mia, Hassan, Hoda, Novotny, Laura A, Bakaletz, Lauren O, Amer, Amal O

“…Legionella pneumophila, the causative agent of Legionnaire's disease, replicates in human alveolar macrophages to establish infection. There is no…”
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