Search Results - "Abt, Michael C."

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity by Abt, Michael C., Osborne, Lisa C., Monticelli, Laurel A., Doering, Travis A., Alenghat, Theresa, Sonnenberg, Gregory F., Paley, Michael A., Antenus, Marcelo, Williams, Katie L., Erikson, Jan, Wherry, E. John, Artis, David

“…Signals from commensal bacteria can influence immune cell development and susceptibility to infectious or inflammatory diseases. However, the mechanisms by…”
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Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness by Pickard, Joseph M., Maurice, Corinne F., Kinnebrew, Melissa A., Abt, Michael C., Schenten, Dominik, Golovkina, Tatyana V., Bogatyrev, Said R., Ismagilov, Rustem F., Pamer, Eric G., Turnbaugh, Peter J., Chervonsky, Alexander V.

“…Systemic exposure to Toll-like receptor (TLR) ligands during sickness is shown to induce fucosylation of the small intestine in mice; some of the fucose is…”
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Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens by Geiger, Theresa L, Abt, Michael C, Gasteiger, Georg, Firth, Matthew A, O'Connor, Margaret H, Geary, Clair D, O'Sullivan, Timothy E, van den Brink, Marcel R, Pamer, Eric G, Hanash, Alan M, Sun, Joseph C

“…The bZIP transcription factor Nfil3 (also known as E4BP4) is required for the development of natural killer (NK) cells and type 1 innate lymphoid cells…”
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Immunological consequences of microbiome-based therapeutics by Alam, Md Zahidul, Maslanka, Jeffrey R, Abt, Michael C

“…The complex network of microscopic organisms living on and within humans, collectively referred to as the microbiome, produce wide array of biologically active…”
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Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection by Littmann, Eric R., Lee, Jung-Jin, Denny, Joshua E., Alam, Zahidul, Maslanka, Jeffrey R., Zarin, Isma, Matsuda, Rina, Carter, Rebecca A., Susac, Bože, Saffern, Miriam S., Fett, Bryton, Mattei, Lisa M., Bittinger, Kyle, Abt, Michael C.

“…Fecal microbiota transplantation (FMT) is a successful therapeutic strategy for treating recurrent Clostridioides difficile infection. Despite remarkable…”
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TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus by Abt, Michael C, Buffie, Charlie G, Sušac, Bože, Becattini, Simone, Carter, Rebecca A, Leiner, Ingrid, Keith, James W, Artis, David, Osborne, Lisa C, Pamer, Eric G

“…Antibiotic administration can disrupt the intestinal microbiota and down-regulate innate immune defenses, compromising colonization resistance against orally…”
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Acute Gastroenteritis Leaves a Lasting Impression by Abt, Michael C.

“…Host immunity shapes intestinal microbiota composition, influencing health and disease. In this issue of Cell Host & Microbe,Kamdar et al. (2016) demonstrate…”
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Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity by Laidlaw, Brian J, Decman, Vilma, Ali, Mohammed-Alkhatim A, Abt, Michael C, Wolf, Amaya I, Monticelli, Laurel A, Mozdzanowska, Krystyna, Angelosanto, Jill M, Artis, David, Erikson, Jan, Wherry, E John

“…Seasonal epidemics of influenza virus result in ∼36,000 deaths annually in the United States. Current vaccines against influenza virus elicit an antibody…”
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Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection by Abt, Michael C., Lewis, Brittany B., Caballero, Silvia, Xiong, Huizhong, Carter, Rebecca A., Sušac, Bože, Ling, Lilan, Leiner, Ingrid, Pamer, Eric G.

“…Infection with the opportunistic enteric pathogen Clostridium difficile is an increasingly common clinical complication that follows antibiotic…”
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Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes by Bustin, Katelyn A, Abbas, Arwa, Wang, Xie, Abt, Michael C, Zackular, Joseph P, Matthews, Megan L

“…Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly…”
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Clostridium difficile colitis: pathogenesis and host defence by Abt, Michael C., McKenney, Peter T., Pamer, Eric G.

“…Key Points Disease that is associated with infection by Clostridium difficile represents an urgent public health threat. The severity of C. difficile infection…”
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Detection and elimination of a novel non-toxigenic Clostridioides difficile strain from the microbiota of a mouse colony by Maslanka, Jeffrey R., Gu, Christopher H., Zarin, Isma, Denny, Joshua E., Broadaway, Susan, Fett, Bryton, Mattei, Lisa M., Walk, Seth T., Abt, Michael C.

“…Clostridioides difficile is an enteric bacterial pathogen that can a cause nosocomial infection leading to debilitating colitis. The development of a murine…”
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Starvation helps transition to abundance – a ferrosome story by Mridha, Subham, Abt, Michael C.

“…Iron is an essential nutrient for bacterial pathogenesis. In their study, Skaar and colleagues (Pi et al.) discovered and determined the detailed structure of…”
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Commensal bacteria mediated defenses against pathogens by Abt, Michael C, Pamer, Eric G

“…Highlights • Commensal bacteria directly inhibit invasive pathogen colonization. • The microbiota indirectly inhibit pathogens by stimulating host defense…”
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An Additive Sugar Helps the C. diff Go Round by Abt, Michael C.

“…Outbreaks of hypervirulent strains of Clostridium difficile began to be reported in healthcare facilities worldwide around 20 years ago. Concurrently,…”
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Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation by Morjaria, Sejal, Zhang, Allen W., Kim, Sohn, Peled, Jonathan U., Becattini, Simone, Littmann, Eric R., Pamer, Eric. G., Abt, Michael C., Perales, Miguel-Angel

“…Background Monocytes are an essential cellular component of the innate immune system that support the host’s effectiveness to combat a range of infectious…”
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Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues by Casey, Kerry A, Fraser, Kathryn A, Schenkel, Jason M, Moran, Amy, Abt, Michael C, Beura, Lalit K, Lucas, Philip J, Artis, David, Wherry, E John, Hogquist, Kristin, Vezys, Vaiva, Masopust, David

“…Differentiation and maintenance of recirculating effector memory CD8 T cells (T(EM)) depends on prolonged cognate Ag stimulation. Whether similar pathways of…”
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Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation by Hill, David A, Siracusa, Mark C, Abt, Michael C, Kim, Brian S, Kobuley, Dmytro, Kubo, Masato, Kambayashi, Taku, LaRosa, David F, Renner, Ellen D, Orange, Jordan S, Bushman, Frederic D, Artis, David

“…Alterations in commensal bacteria are associated with an increased risk of allergic disease. David Artis and his colleagues now report that commensal-derived…”
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The dynamic influence of commensal bacteria on the immune response to pathogens by Abt, Michael C, Artis, David

“…Highlights ► Commensal bacteria influence the immune response to local and systemic pathogens. ► Mammalian hosts and pathogens have evolved to utilize…”
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus by Monticelli, Laurel A, Sonnenberg, Gregory F, Abt, Michael C, Alenghat, Theresa, Ziegler, Carly G K, Doering, Travis A, Angelosanto, Jill M, Laidlaw, Brian J, Yang, Cliff Y, Sathaliyawala, Taheri, Kubota, Masaru, Turner, Damian, Diamond, Joshua M, Goldrath, Ananda W, Farber, Donna L, Collman, Ronald G, Wherry, E John, Artis, David

“…Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate…”
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