Search Results - "Abreu, Joana"

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers by VELTHUIS, Jurjen H, UNGER, Wendy W, SCHUMACHER, Ton N, ROEP, Bart O, ABREU, Joana R. F, DUINKERKEN, Gaby, FRANKEN, Kees, PEAKMAN, Mark, BAKKER, Arnold H, REKER-HADRUP, Sine, KEYMEULEN, Bart, DRIJFHOUT, Jan Wouter

“…Type 1 diabetes results from selective T-cell-mediated destruction of the insulin-producing beta-cells in the pancreas. In this process, islet epitope-specific…”
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Relationship Between C-Peptide Levels, Clinical Features, and Serum Data in a Brazilian Type 1 Diabetes Population with Large Variations in Genomic Ancestry by Azulay, Rossana Sousa, Rodrigues, Vandilson, Lago, Débora Cristina Ferreira, Almeida, Ana Gregória Ferreira Pereira de, Abreu, Joana D'Arc Matos França de, Matos, Lincoln, Andrade, Caio, Nascimento, Gilvan Cortês, Magalhães, Marcelo, Facundo, Alexandre, Oliveira Neto, Clariano Pires de, Sá, Adriana Guimarães, Silva, Dayse Aparecida, Gomes, Marília Brito, Faria, Manuel Dos Santos

“…Type 1 diabetes (T1D) is a chronic disease characterized by the immune-mediated destruction of the pancreatic beta cells responsible for insulin production…”
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Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes by Roep, Bart O, Solvason, Nanette, Gottlieb, Peter A, Abreu, Joana R F, Harrison, Leonard C, Eisenbarth, George S, Yu, Liping, Leviten, Michael, Hagopian, William A, Buse, John B, von Herrath, Matthias, Quan, Joanne, King, Robert S, Robinson, William H, Utz, Paul J, Garren, Hideki, Steinman, Lawrence

“…In type 1 diabetes (T1D), there is an intense inflammatory response that destroys the β cells in the pancreatic islets of Langerhans, the site where insulin is…”
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Data-Integrity Aware Stochastic Model for Cascading Failures in Power Grids by Shuvro, Rezoan Ahmed, Das, Pankaz, Jyoti, Jamir Shariar, Abreu, Joana M., Hayat, Majeed M.

“…The reliable operation of power grids during cascading failures is heavily dependent on the interdependencies between the power grid components and the…”
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A behavior-centered framework for real-time control and load-shedding using aggregated residential energy resources in distribution microgrids by Mammoli, Andrea, Robinson, Matthew, Ayon, Victor, Martínez-Ramón, Manel, Chen, Chien-fei, Abreu, Joana M.

“…•Bottom-up load generator for residential appliance electricity use is described.•Load generator uses statistical characterization of human behavior…”
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Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans by de Jong, V. Martijn, Abreu, Joana R. F., Verrijn Stuart, Annemarie A., van der Slik, Arno R., Verhaeghen, Katrijn, Engelse, Marten A., Blom, Bianca, Staal, Frank J. T., Gorus, Frans K., Roep, Bart O.

“…Aims/hypothesis Thymic expression of self-antigens during T-lymphocyte development is believed to be crucial for preventing autoimmunity. It has been suggested…”
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Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop by James, Eddie A., Abreu, Joana R. F., McGinty, John W., Odegard, Jared M., Fillié, Yvonne E., Hocter, Claire N., Culina, Slobodan, Ladell, Kristin, Price, David A., Alkanani, Aimon, Rihanek, Marynette, Fitzgerald-Miller, Lisa, Skowera, Ania, Speake, Cate, Gottlieb, Peter, Davidson, Howard W., Wong, F. Susan, Roep, Bart, Mallone, Roberto

“…Aims/hypothesis Validated biomarkers are needed to monitor the effects of immune intervention in individuals with type 1 diabetes. Despite their importance,…”
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Impacts of Operators' Behavior on Reliability of Power Grids During Cascading Failures by Wang, Zhuoyao, Rahnamay-Naeini, Mahshid, Abreu, Joana M., Shuvro, Rezoan A., Das, Pankaz, Mammoli, Andrea A., Ghani, Nasir, Hayat, Majeed M.

“…Human operators play a key role in the reliable operation of critical infrastructures. However, human operators may take actions that are far from optimum…”
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Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice by Unger, Wendy W J, Pearson, Todd, Abreu, Joana R F, Laban, Sandra, van der Slik, Arno R, der Kracht, Sacha Mulder-van, Kester, Michel G D, Serreze, Dave V, Shultz, Leonard D, Griffioen, Marieke, Drijfhout, Jan Wouter, Greiner, Dale L, Roep, Bart O

“…Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells,…”
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Using pattern recognition to identify habitual behavior in residential electricity consumption by Abreu, Joana M., Câmara Pereira, Francisco, Ferrão, Paulo

“…► We use residential electricity consumption data sampled every 15min. ► Pattern recognition methodologies to put in evidence habitual behavior. ► Principal…”
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Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers by Unger, Wendy W, Velthuis, Jurjen, Abreu, Joana R.F, Laban, Sandra, Quinten, Edwin, Kester, Michel G.D, Reker-Hadrup, Sine, Bakker, Arnold H, Duinkerken, Gaby, Mulder, Arend, Franken, Kees L.M.C, Hilbrands, Robert, Keymeulen, Bart, Peakman, Mark, Ossendorp, Ferry, Drijfhout, Jan Wouter, Schumacher, Ton N, Roep, Bart O

“…Abstract Autoreactive cytotoxic CD8 T-cells (CTLs) play a key pathogenic role in the destruction of insulin-producing beta-cells resulting in type 1 diabetes…”
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Birth by cesarean delivery and central adiposity in adolescents from a birth cohort by Abreu, Joana D'Arc Matos França de, Abreu, Sterffeson Lamare Lucena de, Bragança, Maylla Luanna Barbosa Martins, Cavalcante, Lilian Fernanda Pereira, França, Ana Karina Teixeira da Cunha, Ribeiro, Cecília Claudia Costa, Lamy Filho, Fernando

“…The aim of this study was to analyze the association between birth by cesarean section and central adiposity in adolescents in São Luís, Maranhão State,…”
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In- and Out-of-Hospital Deaths by Acute Myocardial Infarction in Brazilian State Capitals by Abreu, Sterffeson Lamare Lucena de, Abreu, Joana D'Arc Matos França de, Branco, Maria Dos Remédios Freitas Carvalho, Santos, Alcione Miranda Dos

“…Acute myocardial infarction (AMI) is the main cause of death in Brazil and the world. Approximately half of these deaths occur outside the hospital. To analyze…”
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Health Literacy and Complications in People With Type 2 Diabetes: An Exploratory Study by Cravo, Mariana, Rosendo, Inês, Santiago, Luiz Miguel, Abreu, Joana

“…Introduction: A person with diabetes is subject to developing micro and macrovascular complications and prevention requires an active role from the person. So,…”
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Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis by de Sousa Azulay, Rossana Santiago, Rodrigues, Vandilson, França de Abreu, Joana D’Arc Matos, Pereira de Almeida, Ana Gregória Ferreira, Lago, Débora, Tavares, Maria da Glória, Nascimento, Gilvan, Rocha, Viviane, Magalhães, Marcelo, Facundo, Alexandre, de Oliveira Neto, Clariano Pires, Guimarães Sá, Adriana, Parente, Conceição Ribeiro Veiga, Silva, Dayse Aparecida, Gomes, Marília Brito, Faria, Manuel dos Santos

“…Introduction This study aimed to investigate the sociodemographic factors, dietary adherence, regular physical activity, and genomic ancestry percentage…”
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Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis by de Launay, Daphne, Vreijling, Jeroen, Hartkamp, Linda M, Karpus, Olga N, Abreu, Joana R.F, van Maanen, Marjolein A, Sanders, Marjolein E, Grabiec, Aleksander M, Hamann, Jörg, Ørum, Henrik, Vervoordeldonk, Margriet J, Fluiter, Kees, Tak, Paul P, Reedquist, Kris A

“…Changes in the expression and activation status of Ras proteins are thought to contribute to the pathological phenotype of stromal fibroblast-like synoviocytes…”
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Genetically Engineered Human Islets Protected From CD8-mediated Autoimmune Destruction In Vivo by Zaldumbide, Arnaud, Alkemade, Gonnie, Carlotti, Françoise, Nikolic, Tatjana, Abreu, Joana RF, Engelse, Marten A, Skowera, Anja, de Koning, Eelco J, Peakman, Mark, Roep, Bart O, Hoeben, Rob C, Wiertz, Emmanuel JHJ

“…Islet transplantation is a promising therapy for type 1 diabetes, but graft function and survival are compromised by recurrent islet autoimmunity…”
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Óbitos Intra e Extra-Hospitalares por Infarto Agudo do Miocárdio nas Capitais Brasileiras by Abreu, Sterffeson Lamare Lucena de, Abreu, Joana D’Arc Matos França de, Branco, Maria dos Remédios Freitas Carvalho, Santos, Alcione Miranda dos

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Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes by Malmegrim, Kelen C R, de Azevedo, Júlia T C, Arruda, Lucas C M, Abreu, Joana R F, Couri, Carlos E B, de Oliveira, Gislane L V, Palma, Patricia V B, Scortegagna, Gabriela T, Stracieri, Ana B P L, Moraes, Daniela A, Dias, Juliana B E, Pieroni, Fabiano, Cunha, Renato, Guilherme, Luiza, Santos, Nathália M, Foss, Milton C, Covas, Dimas T, Burt, Richard K, Simões, Belinda P, Voltarelli, Júlio C, Roep, Bart O, Oliveira, Maria C

“…Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces insulin independence in patients with type 1 diabetes. This…”
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A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis by Abreu, Joana Rf, Dontje, Wendy, Krausz, Sarah, de Launay, Daphne, van Hennik, Paula B, van Stalborch, Anne-Marieke, Ten Klooster, Jean-Paul, Sanders, Marjolein E, Reedquist, Kris A, Vervoordeldonk, Margriet J, Hordijk, Peter L, Tak, Paul P

“…The Rho family GTPase Rac1 regulates cytoskeletal rearrangements crucial for the recruitment, extravasation and activation of leukocytes at sites of…”
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