Search Results - "Abrams, Simon Timothy"

Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines by Gardner, Joshua, Abrams, Simon Timothy, Toh, Cheng-Hock, Parker, Alan L., Lovatt, Charlotte, Nicolson, Phillip L. R., Watson, Steve P., Grice, Sophie, Hering, Luisa, Pirmohamed, Munir, Naisbitt, Dean J.

“…Vaccination has proven to be a valuable tool to combat SARS-CoV-2. However, reports of rare adverse reactions such as thrombosis/thrombocytopenia syndrome…”
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Are NETs a Novel, Exciting, Thrombosis Risk Marker? by Wang, Guozheng, Abrams, Simon Timothy, Toh, Cheng-Hock

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Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation by Shaw, Rebecca Jane, Austin, James, Taylor, Joseph, Dutt, Tina, Wang, Guozheng, Abrams, Simon Timothy, Toh, Cheng Hock

“…▪ Background The COVID-19 pandemic has highlighted the potentially lethal consequences of cross-talk between coagulation, inflammation and innate immune…”
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Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation by Abrams, Simon Timothy, Su, Dunhao, Sahraoui, Yasmina, Alhamdi, Yasir, Wang, Guozheng, Toh, Cheng Hock

“…Background: Increased thrombin generation in vivo is pivotal to the development of disseminated intravascular coagulation (DIC). Typically, thrombin is…”
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A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies by Abrams, Simon Timothy, Morton, Ben, Alhamdi, Yasir, Alsabani, Mohmad, Cheng, Zhenxing, Lane, Steven, Welters, Ingeborg, Wang, Guozheng, Toh, Cheng-Hock

“…Background Neutrophils are the first line of defence against bacterial infection and formation of neutrophil extracellular traps (NETs) is an important…”
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Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response by Abrams, Simon Timothy, Zhang, Nan, Wang, Guozheng, Toh, Cheng-Hock

“…Whilst histones are essential building blocks within cells in forming the basis of chromatin, their extracellular effects can be extremely toxic. We have shown…”
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Assembly of alternative prothrombinase by extracellular histones initiate and disseminate intravascular coagulation by Abrams, Simon Timothy, Su, Dunhao, Sahraoui, Yasmina, Lin, Ziqi, Cheng, Zhenxing, Nesbitt, Kate, Alhamdi, Yasir, Harrasser, Micaela, Du, Min, Foley, Jonathan, Lillicrap, David, Wang, Guozheng, Toh, Cheng-Hock

“…Thrombin generation is pivotal to both physiological blood clot formation and pathological development of disseminated intravascular coagulation (DIC). In…”
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