Search Results - "Abramowski, Dorothee"

Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease by Busche, Marc Aurel, Eichhoff, Gerhard, Adelsberger, Helmuth, Abramowski, Dorothee, Wiederhold, Karl-Heinz, Haass, Christian, Staufenbiel, Matthias, Konnerth, Arthur, Garaschuk, Olga

“…The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested…”
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CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions by Munoz, Diana M, Cassiani, Pamela J, Li, Li, Billy, Eric, Korn, Joshua M, Jones, Michael D, Golji, Javad, Ruddy, David A, Yu, Kristine, McAllister, Gregory, DeWeck, Antoine, Abramowski, Dorothee, Wan, Jessica, Shirley, Matthew D, Neshat, Sarah Y, Rakiec, Daniel, de Beaumont, Rosalie, Weber, Odile, Kauffmann, Audrey, McDonald, 3rd, E Robert, Keen, Nicholas, Hofmann, Francesco, Sellers, William R, Schmelzle, Tobias, Stegmeier, Frank, Schlabach, Michael R

“…CRISPR/Cas9 has emerged as a powerful new tool to systematically probe gene function. We compared the performance of CRISPR to RNAi-based loss-of-function…”
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The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors by Mang, Géraldine M, Dürst, Thomas, Bürki, Hugo, Imobersteg, Stefan, Abramowski, Dorothee, Schuepbach, Edi, Hoyer, Daniel, Fendt, Markus, Gee, Christine E

“…Orexin peptides activate orexin 1 and orexin 2 receptors (OX(1)R and OX(2)R), regulate locomotion and sleep-wake. The dual OX(1)R/OX(2)R antagonist almorexant…”
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Dietary Cu Stabilizes Brain Superoxide Dismutase 1 Activity and Reduces Amyloid Aβ Production in APP23 Transgenic Mice by Bayer, Thomas A., Schäfer, Stephanie, Simons, Andreas, Kemmling, André, Kamer, Thomas, Tepest, Ralf, Eckert, Anne, Schüssel, Katrin, Eikenberg, Oliver, Sturchler-Pierrat, Christine, Abramowski, Dorothee, Staufenbiel, Matthias, Multhaup, Gerd

“…The Cu-binding β-amyloid precursor protein (APP), and the amyloid Aβ peptide have been proposed to play a role in physiological metal regulation. There is…”
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Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model by VAN DAM, Debby, ABRAMOWSKI, Dorothee, STAUFENBIEL, Matthias, DE DEYN, Peter Paul

“…APP23 mice are a promising model of Alzheimer's disease, expressing several histopathological, cognitive and behavioural hallmarks of the human condition. A…”
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Mutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 mice by Young, Douglas, Mayer, Franziska, Vidotto, Nella, Schweizer, Tatjana, Berth, Ramon, Abramowski, Dorothee, Shimshek, Derya R, van der Putten, P Herman, Schmid, Peter

“…Huntington's disease (HD) is an autosomal dominant, progressive and fatal neurological disorder caused by an expansion of CAG repeats in exon-1 of the…”
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Two Amyloid Precursor Protein Transgenic Mouse Models with Alzheimer Disease-Like Pathology by Sturchler-Pierrat, Christine, Abramowski, Dorothee, Duke, Mairead, Wiederhold, Karl-Heinz, Mistl, Claudia, Rothacher, Sabin, Ledermann, Brigit, Bürki, Kurt, Frey, Peter, Paganetti, Paolo A., Waridel, Caroline, Calhoun, Michael E., Jucker, Mathias, Probst, Alphonse, Staufenbiel, Matthias, Sommer, Bernd

“…Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the formation of the amyloid β (Aβ )…”
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Neuronal Overexpression of Mutant Amyloid Precursor Protein Results in Prominent Deposition of Cerebrovascular Amyloid by Calhoun, Michael E., Burgermeister, Patrick, Phinney, Amie L., Stalder, Martina, Tolnay, Markus, Wiederhold, Karl-Heinz, Abramowski, Dorothee, Sturchler-Pierrat, Christine, Sommer, Bernd, Staufenbiel, Matthias, Jucker, Mathias

“…Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer's disease pathology, namely the extracellular…”
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Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging by Marcellin, David, Abramowski, Dorothee, Young, Douglas, Richter, Jens, Weiss, Andreas, Marcel, Audrey, Maassen, Julia, Kauffmann, Muriel, Bibel, Miriam, Shimshek, Derya R, Faull, Richard L M, Bates, Gillian P, Kuhn, Rainer R, Van der Putten, P Herman, Schmid, Peter, Lotz, Gregor P

“…Cleavage of the full-length mutant huntingtin (mhtt) protein into smaller, soluble aggregation-prone mhtt fragments appears to be a key process in the…”
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Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice by Paganetti, Paolo, Reichwald, Julia, Bleckmann, Dorothee, Abramowski, Dorothee, Ammaturo, Domenico, Barske, Carmen, Danner, Simone, Molinari, Maurizio, Müller, Matthias, Papin, Stéphanie, Rabe, Sabine, Schmid, Peter, Staufenbiel, Matthias

“…Abstract Heterologous expression of the functional amyloid beta (Aβ) antibody β1 in the central nervous system was engineered to maximize antibody exposure in…”
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Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain by Lütjohann, Dieter, Brzezinka, Andreas, Barth, Esther, Abramowski, Dorothee, Staufenbiel, Matthias, von Bergmann, Klaus, Beyreuther, Konrad, Multhaup, Gerd, Bayer, Thomas A

“…Cholesterol is implicated to play a role in Alzheimer disease pathology. Therefore, the concentrations of cholesterol, its precursors, and its degradation…”
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Noninvasive Magnetic Resonance Imaging Detection of Cerebral Amyloid Angiopathy-Related Microvascular Alterations Using Superparamagnetic Iron Oxide Particles in APP Transgenic Mouse Models of Alzheimer's Disease: Application to Passive Aβ Immunotherapy by Beckmann, Nicolau, Gérard, Christelle, Abramowski, Dorothée, Cannet, Catherine, Staufenbiel, Matthias

“…Cerebral amyloid angiopathy (CAA) is a common feature of Alzheimer's disease (AD). More advanced stages are accompanied by microhemorrhages and vasculitis…”
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APP23 Mice as a Model of Alzheimer's Disease: An Example of a Transgenic Approach to Modeling a CNS Disorder by Van Dam, Debby, Vloeberghs, Ellen, Abramowski, Dorothee, Staufenbiel, Matthias, De Deyn, Peter Paul

“…Animal models are considered essential in research ensuing elucidation of human disease processes and subsequently, testing of potential therapeutic…”
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Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington’s disease by Weiss, Andreas, Abramowski, Dorothée, Bibel, Miriam, Bodner, Ruth, Chopra, Vanita, DiFiglia, Marian, Fox, Jonathan, Kegel, Kimberly, Klein, Corinna, Grueninger, Stephan, Hersch, Steven, Housman, David, Régulier, Etienne, Rosas, H. Diana, Stefani, Muriel, Zeitlin, Scott, Bilbe, Graeme, Paganetti, Paolo

“…The genetic mutation causing Huntington’s disease is a polyglutamine expansion in the huntingtin protein where more than 37 glutamines cause disease by…”
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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening by McDonald, E. Robert, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, Sellers, William R.

“…Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant…”
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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host by Meyer-Luehmann, Melanie, Coomaraswamy, Janaky, Bolmont, Tristan, Kaeser, Stephan, Schaefer, Claudia, Kilger, Ellen, Neuenschwander, Anton, Abramowski, Dorothee, Frey, Peter, Jaton, Anneliese L., Vigouret, Jean-Marie, Paganetti, Paolo, Walsh, Dominic M., Mathews, Paul M., Ghiso, Jorge, Staufenbiel, Matthias, Walker, Lary C., Jucker, Mathias

“…Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo…”
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Identification of the 5-hydroxytryptamine2C receptor as a 60-kDa N-glycosylated protein in choroid plexus and hippocampus by Abramowski, D, Staufenbiel, M

“…The rat 5-hydroxytryptamine2C (5-HT2C) receptor was identified as N-glycosylated polypeptide of 60-kDa apparent molecular mass using antibodies against its…”
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Exogenous Induction of Cerebral β-Amyloidogenesis Is Governed by Agent and Host by Meyer-Luehmann, Melanie, Coomaraswamy, Janaky, Bolmont, Tristan, Kaeser, Stephan, Schaefer, Claudia, Kilger, Ellen, Neuenschwander, Anton, Abramowski, Dorothee, Frey, Peter, Jaton, Anneliese L, Vigouret, Jean-Marie, Paganetti, Paolo, Walsh, Dominic M, Mathews, Paul M, Ghiso, Jorge, Staufenbiel, Matthias, Walker, Lary C, Jucker, Mathias

“…Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo…”
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Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count by Weiss, Andreas, Grueninger, Stephan, Abramowski, Dorothée, Giorgio, Francesco Paolo Di, Lopatin, Miriam Moscovitch, Rosas, H. Diana, Hersch, Steven, Paganetti, Paolo

“…Huntington’s disease is caused by a gain-of-function neurotoxic mutation in normally neuroprotective huntingtin. Sensitive assays are required to discriminate…”
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