Search Results - "Abramov, Y"

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration by Angelova, Plamena R., Abramov, Andrey Y.

“…Mitochondria are key cell organelles in that they are responsible for energy production and control many processes from signalling to cell death. The function…”
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Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond by Esteras, Noemí, Abramov, Andrey Y.

“…Mitochondria are unique and essential organelles that mediate many vital cellular processes including energy metabolism and cell death. The transcription…”
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The emerging role of Nrf2 in mitochondrial function by Dinkova-Kostova, Albena T., Abramov, Andrey Y.

“…The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene…”
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Functional role of mitochondrial reactive oxygen species in physiology by Angelova, Plamena R., Abramov, Andrey Y.

“…The major energy generator in the cell – mitochondria produce reactive oxygen species as a by-product of a number of enzymatic reactions and the production of…”
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Mechanism of Oxidative Stress in Neurodegeneration by Gandhi, Sonia, Abramov, Andrey Y.

“…Biological tissues require oxygen to meet their energetic demands. However, the consumption of oxygen also results in the generation of free radicals that may…”
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Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function by Esteras, Noemí, Dinkova-Kostova, Albena T, Abramov, Andrey Y

“…The nuclear factor erythroid-derived 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor well-known for its function in controlling the basal and…”
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Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology by Esteras, Noemi, Abramov, Andrey Y

“…Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as Alzheimer's disease…”
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Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria by Baev, Artyom Y, Angelova, Plamena R, Abramov, Andrey Y

“…Inorganic polyphosphate (polyP) is a polymer present in all living organisms. Although polyP is found to be involved in a variety of functions in cells of…”
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Nrf2 affects the efficiency of mitochondrial fatty acid oxidation by Ludtmann, Marthe H R, Angelova, Plamena R, Zhang, Ying, Abramov, Andrey Y, Dinkova-Kostova, Albena T

“…Transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the cellular redox homoeostasis and cytoprotective responses, allowing adaptation and survival…”
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Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease by Dolgacheva, Ludmila P., Berezhnov, Alexey V., Fedotova, Evgeniya I., Zinchenko, Valery P., Abramov, Andrey Y.

“…DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as…”
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Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase by Esteras, Noemi, Kundel, Franziska, Amodeo, Giuseppe F., Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y.

“…Most neurodegenerative disorders are associated with aggregation and accumulation of misfolded proteins. One of these proteins, tau, is involved in a number of…”
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease by Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia

“…Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions,…”
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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation by Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia

“…Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that…”
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KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy by Shekh-Ahmad, Tawfeeq, Eckel, Ramona, Dayalan Naidu, Sharadha, Higgins, Maureen, Yamamoto, Masayuki, Dinkova-Kostova, Albena T, Kovac, Stjepana, Abramov, Andrey Y, Walker, Matthew C

“…Reactive oxygen species are hypothesised to play a critical role in the development of epilepsy. Shekh-Ahmad et al. report that decreasing reactive oxygen…”
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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons by Wood-Kaczmar, Alison, Gandhi, Sonia, Yao, Zhi, Abramov, Andrey Y, Abramov, Andrey S Y, Miljan, Erik A, Keen, Gregory, Stanyer, Lee, Hargreaves, Iain, Klupsch, Kristina, Deas, Emma, Downward, Julian, Mansfield, Louise, Jat, Parmjit, Taylor, Joanne, Heales, Simon, Duchen, Michael R, Latchman, David, Tabrizi, Sarah J, Wood, Nicholas W

“…Parkinson's disease (PD) is a common age-related neurodegenerative disease and it is critical to develop models which recapitulate the pathogenic process…”
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PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons by Kostic, Marko, Ludtmann, Marthe H.R., Bading, Hilmar, Hershfinkel, Michal, Steer, Erin, Chu, Charleen T., Abramov, Andrey Y., Sekler, Israel

“…Mitochondrial Ca2+ overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic insults. We found that loss of…”
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Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein by Cremades, Nunilo, Cohen, Samuel I.A., Deas, Emma, Abramov, Andrey Y., Chen, Allen Y., Orte, Angel, Sandal, Massimo, Clarke, Richard W., Dunne, Paul, Aprile, Francesco A., Bertoncini, Carlos W., Wood, Nicholas W., Knowles, Tuomas P.J., Dobson, Christopher M., Klenerman, David

“…Here, we use single-molecule techniques to study the aggregation of α-synuclein, the protein whose misfolding and deposition is associated with Parkinson's…”
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Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase by Ludtmann, Marthe H R, Angelova, Plamena R, Ninkina, Natalia N, Gandhi, Sonia, Buchman, Vladimir L, Abramov, Andrey Y

“…Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD). However, knowledge about a physiological role for the native, unfolded…”
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Mutations in ANO3 Cause Dominant Craniocervical Dystonia: Ion Channel Implicated in Pathogenesis by Charlesworth, Gavin, Plagnol, Vincent, Holmström, Kira M., Bras, Jose, Sheerin, Una-Marie, Preza, Elisavet, Rubio-Agusti, Ignacio, Ryten, Mina, Schneider, Susanne A., Stamelou, Maria, Trabzuni, Daniah, Abramov, Andrey Y., Bhatia, Kailash P., Wood, Nicholas W.

“…In this study, we combined linkage analysis with whole-exome sequencing of two individuals to identify candidate causal variants in a moderately-sized UK…”
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Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation by Abramov, Andrey Y, Scorziello, Antonella, Duchen, Michael R

“…Ischemia is a major cause of brain damage, and patient management is complicated by the paradoxical injury that results from reoxygenation. We have now…”
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