Search Results - "Abrahamsson, Annelie"

Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women by Lindahl, Gabriel, Abrahamsson, Annelie, Dabrosin, Charlotta

“…Background Anti-oestrogens such as tamoxifen, decrease the risk of breast cancer but are unsuitable for prevention because of their side-effects. Diet…”
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CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer by Svensson, Susanne, Abrahamsson, Annelie, Rodriguez, Gabriela Vazquez, Olsson, Anna-Karin, Jensen, Lasse, Cao, Yihai, Dabrosin, Charlotta

“…Novel therapeutic targets of estrogen receptor (ER)-positive breast cancers are urgently needed because current antiestrogen therapy causes severe adverse…”
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Equal Pro-inflammatory Profiles of CCLs, CXCLs, and Matrix Metalloproteinases in the Extracellular Microenvironment In Vivo in Human Dense Breast Tissue and Breast Cancer by Abrahamsson, Annelie, Rzepecka, Anna, Dabrosin, Charlotta

“…The inflammatory microenvironment affects breast cancer progression. Proteins that govern the inflammatory response are secreted into the extracellular space,…”
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Breast density and estradiol are associated with distinct different expression patterns of metabolic proteins in normal human breast tissue in vivo by Ekstrand, Jimmy, Abrahamsson, Annelie, Lundberg, Peter, Dabrosin, Charlotta

“…Breast density and exposure to sex steroids are major risk factors for breast cancer. The local microenvironment plays an essential role in progression of…”
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Tamoxifen, Flaxseed, and the Lignan Enterolactone Increase Stroma- and Cancer Cell-Derived IL-1Ra and Decrease Tumor Angiogenesis in Estrogen-Dependent Breast Cancer by LINDAHL, Gabriel, SAARINEN, Niina, ABRAHAMSSON, Annelie, DABROSIN, Charlotta

“…The proinflammatory cytokines IL-1α and IL-1β promote tumor angiogenesis that might be counteracted by the IL-1 receptor antagonist (IL-1Ra), anakinra, a…”
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Estradiol Promotes Breast Cancer Cell Migration via Recruitment and Activation of Neutrophils by Vazquez Rodriguez, Gabriela, Abrahamsson, Annelie, Jensen, Lasse Dahl Ejby, Dabrosin, Charlotta

“…Estradiol (E ) plays a key role in breast cancer progression. Most breast cancer recurrences express the estrogen receptor (ER), but nearly 50% of patients are…”
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Breast Density and Estradiol Are Major Determinants for Soluble TNF-TNF-R Proteins in vivo in Human Breast Tissue by Ekstrand, Jimmy, Zemmler, Maja, Abrahamsson, Annelie, Lundberg, Peter, Forsgren, Mikael, Dabrosin, Charlotta

“…High mammographic density and exposure to sex steroids are independent risk factors for breast cancer by yet unknown mechanisms. Inflammation is one hallmark…”
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Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women by Lundberg, Peter, Abrahamsson, Annelie, Kihlberg, Johan, Tellman, Jens, Tomkeviciene, Ieva, Karlsson, Anette, Kristoffersen Wiberg, Maria, Warntjes, Marcel, Dabrosin, Charlotta

“…One major risk factor for breast cancer is high mammographic density. It has been estimated that dense breast tissue contributes to ~ 30% of all breast cancer…”
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Glycogen synthase kinase 3β missplicing contributes to leukemia stem cell generation by Abrahamsson, Annelie E, Geron, Ifat, Gotlib, Jason, Dao, Kim-Hien T, Barroga, Charlene F, Newton, Isabel G, Giles, Francis J, Durocher, Jeffrey, Creusot, Remi S, Karimi, Mobin, Jones, Carol, Zehnder, James L, Keating, Armand, Negrin, Robert S, Weissman, Irving L, Jamieson, Catriona H.M

“…Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is responsible for cancer progression and therapeutic resistance…”
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Lysine in Combination With Estradiol Promote Dissemination of Estrogen Receptor Positive Breast Cancer via Upregulation of U2AF1 and RPN2 Proteins by Vazquez Rodriguez, Gabriela, Abrahamsson, Annelie, Turkina, Maria V, Dabrosin, Charlotta

“…The majority of estrogen receptor positive (ER+) breast cancer (BC) maintain the ER at metastatic sites. Despite anti-estrogen therapy, almost 30% of ER+ BC…”
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Adipocytes Promote Early Steps of Breast Cancer Cell Dissemination via Interleukin-8 by Vazquez Rodriguez, Gabriela, Abrahamsson, Annelie, Jensen, Lasse Dahl Ejby, Dabrosin, Charlotta

“…Fat is a major tissue component in human breast cancer (BC). Whether breast adipocytes (BAd) affect early stages of BC metastasis is yet unknown. BC…”
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Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer by Leifler, Karin Söderlund, Svensson, Susanne, Abrahamsson, Annelie, Bendrik, Christina, Robertson, Jennifer, Gauldie, Jack, Olsson, Anna-Karin, Dabrosin, Charlotta

“…Matrix metalloproteinases (MMPs) have been suggested as therapeutic targets in cancer treatment, but broad-spectrum MMP inhibitors have failed in clinical…”
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Estrogen‐induced angiogenic factors derived from stromal and cancer cells are differently regulated by enterolactone and genistein in human breast cancer in vivo by Saarinen, Niina M., Abrahamsson, Annelie, Dabrosin, Charlotta

“…Angiogenesis is a key in cancer progression and its regulators are released both by the tumor cells and the stroma. Dietary phytoestrogens, such as the lignan…”
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Selective Inhibition of JAK2-Driven Erythroid Differentiation of Polycythemia Vera Progenitors by Geron, Ifat, Abrahamsson, Annelie E., Barroga, Charlene F., Kavalerchik, Edward, Gotlib, Jason, Hood, John D., Durocher, Jeffrey, Mak, Chi Ching, Noronha, Glenn, Soll, Richard M., Tefferi, Ayalew, Kaushansky, Ken, Jamieson, Catriona H.M.

“…Polycythemia Vera (PV) is a myeloproliferative disorder (MPD) that is commonly characterized by mutant JAK2 (JAK2V617F) signaling, erythrocyte overproduction,…”
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Tamoxifen and flaxseed alter angiogenesis regulators in normal human breast tissue in vivo by Åberg, Ulrika W Nilsson, Saarinen, Niina, Abrahamsson, Annelie, Nurmi, Tarja, Engblom, Sofia, Dabrosin, Charlotta

“…The incidence of breast cancer is increasing in the Western world and there is an urgent need for studies of the mechanisms of sex steroids in order to develop…”
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Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer by Lindahl, Gabriel, Fjellander, Sebastian, Selvaraj, Karthik, Vildeval, Malin, Ali, Zaheer, Almter, Rusul, Erkstam, Anna, Rodriguez, Gabriela Vazquez, Abrahamsson, Annelie, Kersley, Åsa Rydmark, Fahlgren, Anna, Kjølhede, Preben, Linder, Stig, Dabrosin, Charlotta, Jensen, Lasse

“…Epithelial ovarian cancer (EOC) is the gynaecological malignancy with highest mortality. Although adjuvant treatment with carboplatin and paclitaxel leads to…”
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Islet Specific Wnt Activation in Human Type II Diabetes by Lee, Seung-Hee, Demeterco, Carla, Geron, Ifat, Abrahamsson, Annelie, Levine, Fred, Itkin-Ansari, Pamela

“…The Wnt pathway effector gene TCF7L2 has been linked to type II diabetes, making it important to study the role of Wnt signaling in diabetes pathogenesis. We…”
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Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo by Abrahamsson, Annelie, Dabrosin, Charlotta

“…Extracellular circulating microRNAs (miRNAs) have been suggested to be biomarkers for disease monitoring but data are inconsistent, one reason being that blood…”
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Optical imaging of progenitor cell homing to patient-derived tumors by Newton, Isabel G, Plaisted, Warren C, Messina-Graham, Steven, Abrahamsson Schairer, Annelie E, Shih, Alice Y, Snyder, Evan Y, Jamieson, Catriona H M, Mattrey, Robert F

“…Capitalizing on cellular homing to cancer is a promising strategy for targeting malignant cells for diagnostic, monitoring and therapeutic purposes. Murine…”
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Fulvestrant-Mediated Attenuation of the Innate Immune Response Decreases ER + Breast Cancer Growth In Vivo More Effectively than Tamoxifen by Abrahamsson, Annelie, Rodriguez, Gabriela Vazquez, Dabrosin, Charlotta

“…Although blocking estrogen-dependent signaling is a cornerstone of adjuvant treatment for breast cancer, 25% of patients experience recurrent disease. Stroma…”
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