Search Results - "Abrahams, Vikki M."

Visualization and Quantification of Neutrophil Extracellular Traps by Tong, Mancy, Abrahams, Vikki M

“…Neutrophils are innate immune cells that play important roles in many physiological and pathological processes, including immune defense and cancer metastasis…”
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Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development by Ilekis, John V., PhD, Tsilou, Ekaterini, MD, Fisher, Susan, PhD, Abrahams, Vikki M., PhD, Soares, Michael J., PhD, Cross, James C., PhD, Zamudio, Stacy, PhD, Illsley, Nicholas P., DPhil, Myatt, Leslie, PhD, Colvis, Christine, PhD, Costantine, Maged M., MD, Haas, David M., MD, Sadovsky, Yoel, MD, Weiner, Carl, MD, Rytting, Erik, PhD, Bidwell, Gene, PhD

“…Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related…”
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The role of the Nod-like receptor family in trophoblast innate immune responses by Abrahams, Vikki M

“…Abstract There is a strong clinical association between intrauterine infections and pregnancy complications, such as preterm labor. The placenta functions as…”
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Mechanisms of Endothelial Dysfunction in Antiphospholipid Syndrome: Association With Clinical Manifestations by Velásquez, Manuela, Rojas, Mauricio, Abrahams, Vikki M, Escudero, Carlos, Cadavid, Ángela P

“…The endothelium is a monolayer of cells that covers the inner surface of blood vessels and its integrity is essential for the maintenance of vascular health…”
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A Role for the Inflammasome in Spontaneous Labor at Term by Romero, Roberto, Xu, Yi, Plazyo, Olesya, Chaemsaithong, Piya, Chaiworapongsa, Tinnakorn, Unkel, Ronald, Than, Nandor Gabor, Chiang, Po Jen, Dong, Zhong, Xu, Zhonghui, Tarca, Adi L., Abrahams, Vikki M., Hassan, Sonia S., Yeo, Lami, Gomez‐Lopez, Nardhy

“…Problem Inflammasomes are signaling platforms that, upon sensing pathogens and sterile stressors, mediate the release of mature forms of interleukin (IL)‐1β…”
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Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction by Brien, Marie-Eve, Duval, Cyntia, Palacios, Julia, Boufaied, Ines, Hudon-Thibeault, Andrée-Anne, Nadeau-Vallée, Mathieu, Vaillancourt, Cathy, Sibley, Colin P, Abrahams, Vikki M, Jones, Rebecca L, Girard, Sylvie

“…Excessive placental inflammation is associated with several pathological conditions, including stillbirth and fetal growth restriction. Although infection is a…”
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Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8 by Gysler, Stefan M, Mulla, Melissa J, Guerra, Marta, Brosens, Jan J, Salmon, Jane E, Chamley, Lawrence W, Abrahams, Vikki M

“…What is the role of microRNAs (miRs) in antiphospholipid antibody (aPL)-induced trophoblast inflammation? aPL-induced up-regulation of trophoblast miR-146a-3p…”
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Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll‐Like receptor 4 by Heim, Kathleen R., Mulla, Melissa J., Potter, Julie A., Han, Christina S., Guller, Seth, Abrahams, Vikki M.

“…Problem Hyperglycemia increases the risk of preeclampsia. Hyperglycemia induces a placental trophoblast inflammatory (IL‐1β, IL‐6, IL‐8), antiangiogenic…”
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A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast by Mulla, Melissa J, Salmon, Jane E, Chamley, Larry W, Brosens, Jan J, Boeras, Crina M, Kavathas, Paula B, Abrahams, Vikki M

“…Women with antiphospholipid syndrome (APS) are at risk of recurrent pregnancy loss and obstetrical disorders, such as preeclampsia and intrauterine growth…”
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Zika virus productively infects primary human placenta-specific macrophages by Jurado, Kellie Ann, Simoni, Michael K, Tang, Zhonghua, Uraki, Ryuta, Hwang, Jesse, Householder, Sarah, Wu, Mingjie, Lindenbach, Brett D, Abrahams, Vikki M, Guller, Seth, Fikrig, Erol

“…The strong association of Zika virus infection with congenital defects has led to questions of how a flavivirus is capable of crossing the placental barrier to…”
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Mechanisms of antiphospholipid antibody-associated pregnancy complications by Abrahams, Vikki M

“…Abstract Women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) are at high risk for recurrent spontaneous miscarriage and late…”
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Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages by Pantazi, Paschalia, Clements, Toby, Venø, Morten, Abrahams, Vikki M., Holder, Beth

“…Macrophages are important antigen presenting cells which can release extracellular vesicles (EVs) carrying functional cargo including non‐coding RNAs…”
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TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer by KELLY, Michael G, ALVERO, Ayesha B, RUI CHEN, SILASI, Dan-Arin, ABRAHAMS, Vikki M, CHAN, Serena, VISINTIN, Irene, RUTHERFORD, Thomas, MOR, Gil

“…Evidence suggests that an inflammatory profile of cytokines and chemokines persisting at a particular site would lead to the development of a chronic disease…”
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The role of anti-phospholipid antibodies in autoimmune reproductive failure by Pantham, Priyadarshini, Abrahams, Vikki M, Chamley, Lawrence W

“…Abstract Anti-phospholipid antibodies (aPL) are autoantibodies that are associated with thrombosis and a range of pregnancy complications including recurrent…”
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The Role of Apoptosis in the Regulation of Trophoblast Survival and Differentiation during Pregnancy by Straszewski-Chavez, Shawn L, Abrahams, Vikki M, Mor, Gil

“…Apoptosis is important for normal placental development, but it may also be involved in the pathophysiology of pregnancy-related diseases. Normal placental…”
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Antiphospholipid Antibodies Inhibit Trophoblast Toll‐Like Receptor and Inflammasome Negative Regulators by Mulla, Melissa J., Weel, Ingrid C., Potter, Julie A., Gysler, Stefan M., Salmon, Jane E., Peraçoli, Maria T. S., Rothlin, Carla V., Chamley, Lawrence W., Abrahams, Vikki M.

“…Objective Women with antiphospholipid antibodies (aPL) are at risk for pregnancy complications associated with poor placentation and placental inflammation…”
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Aspirin‐Triggered Lipoxin Prevents Antiphospholipid Antibody Effects on Human Trophoblast Migration and Endothelial Cell Interactions by Alvarez, Angela M., Mulla, Melissa J., Chamley, Lawrence W., Cadavid, Angela P., Abrahams, Vikki M.

“…Objective Antiphospholipid antibodies (aPL) interfere with several physiologic functions of human trophoblasts, including reducing their ability to migrate,…”
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Identification of microRNAs that regulate TLR2-mediated trophoblast apoptosis and inhibition of IL-6 mRNA by Garg, Manish, Potter, Julie A, Abrahams, Vikki M

“…While infection-induced placental inflammation is a common mechanism of adverse pregnancy outcome, some pathogens can also trigger placental apoptosis, and…”
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Antiphospholipid Antibodies From Women With Pregnancy Morbidity and Vascular Thrombosis Induce Endothelial Mitochondrial Dysfunction, mTOR Activation, and Autophagy by Rodríguez, Carlos M, Velásquez-Berrío, Manuela, Rúa, Carolina, Viana, Marta, Abrahams, Vikki M, Cadavid, Angela P, Alvarez, Angela M

“…Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis and pregnancy morbidity (PM) obstetric events together with persistent…”
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Immune cell activation by trophoblast‐derived microvesicles is mediated by syncytin 1 by Holder, Beth S., Tower, Clare L., Forbes, Karen, Mulla, Melissa J., Aplin, John D., Abrahams, Vikki M.

“…Summary Envelope glycoproteins of human endogenous retrovirus (HERV), such as syncytin 1 (HERV‐W), are highly expressed in the placenta and some family members…”
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