Search Results - "Abrahams, Dominique"

T-cells produce acidic niches in lymph nodes to suppress their own effector functions by Wu, Hao, Estrella, Veronica, Beatty, Matthew, Abrahams, Dominique, El-Kenawi, Asmaa, Russell, Shonagh, Ibrahim-Hashim, Arig, Longo, Dario Livio, Reshetnyak, Yana K., Moshnikova, Anna, Andreev, Oleg A., Luddy, Kimberly, Damaghi, Mehdi, Kodumudi, Krithika, Pillai, Smitha R., Enriquez-Navas, Pedro, Pilon-Thomas, Shari, Swietach, Pawel, Gillies, Robert J.

“…The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune…”
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Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells by Huynh, Amanda Shanks, Abrahams, Dominique F, Torres, Monica S, Baldwin, Margaret K, Gillies, Robert J, Morse, David L

“…Mice have been employed as models of cancer for over a century, providing significant advances in our understanding of this multifaceted family of diseases. In…”
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Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model by Abrahams, Dominique, Ibrahim-Hashim, Arig, Ackerman, Robert S, Brown, Joel S, Whelan, Christopher J, Garfinkel, Megan B, Gatenby, Robert A, Muncey, Aaron R

“…Volatile and intravenous anesthetics may worsen oncologic outcomes in basic science animal models. These effects may be related to suppressed innate and…”
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Systemic buffers inhibit carcinogenesis in TRAMP mice by Ibrahim-Hashim, Arig, Cornnell, Heather H, Abrahams, Dominique, Lloyd, Mark, Bui, Marilyn, Gillies, Robert J, Gatenby, Robert A

“…Hypoxia and acidosis develop in in situ tumors as cellular expansion increases the diffusion distance of substrates and metabolites from blood vessels deep to…”
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Proton export upregulates aerobic glycolysis by Russell, Shonagh, Xu, Liping, Kam, Yoonseok, Abrahams, Dominique, Ordway, Bryce, Lopez, Alex S, Bui, Marilyn M, Johnson, Joseph, Epstein, Tamir, Ruiz, Epifanio, Lloyd, Mark C, Swietach, Pawel, Verduzco, Daniel, Wojtkowiak, Jonathan, Gillies, Robert J

“…Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the "Warburg…”
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Targeting myeloid-derived suppressor cells with gemcitabine to enhance efficacy of adoptive cell therapy in bladder cancer by Bazargan, Sarah, Bunch, Brittany, Ojwang', Awino Maureiq E, Blauvelt, Jamie, Landin, Annick, Ali, Johannes, Abrahams, Dominique, Cox, Cheryl, Hall, Amy M, Beatty, Matthew S, Poch, Michael, Rejniak, Katarzyna A, Pilon-Thomas, Shari

“…New therapeutics in development for bladder cancer need to address the recalcitrant nature of the disease. Intravesical adoptive cell therapy (ACT) with tumor…”
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Equipment and Methods for Concurrently Housing Germfree and Gnotobiotic Mice in the Same Room by Muino, Anastasia F, Compo, Nicole R, Everett, Bo M, Abrahams, Dominique F, Baldwin, Margi K, James, Tara N, Wanner, Susan E, Perkins, M Jane, Parr, Courtnee E, Wiltshire, Norman D, Miedel, Emily L, Engelman, Robert W

“…Here, we combined the use of 2 technologies that have not previously been used together—a positively pressurized isolatorIVC (IsoIVC-P) and a modular isolator…”
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Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes by TAFRESHI, Narges K, BUI, Marilyn M, GILLIES, Robert J, MORSE, David L, BISHOP, Kellsey, LLOYD, Mark C, ENKEMANN, Steven A, LOPEZ, Alexis S, ABRAHAMS, Dominique, CARTER, Bradford W, VAGNER, Josef, GOBMYER, Stephen R

“…To develop targeted molecular imaging probes for the noninvasive detection of breast cancer lymph node metastasis. Six cell surface or secreted markers were…”
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Reduction of metastasis using a non-volatile buffer by Ibrahim Hashim, Arig, Cornnell, Heather H., Coelho Ribeiro, Maria de Lourdes, Abrahams, Dominique, Cunningham, Jessica, Lloyd, Mark, Martinez, Gary V., Gatenby, Robert A., Gillies, Robert J.

“…The tumor microenvironment is acidic as a consequence of upregulated glycolysis and poor perfusion and this acidity, in turn, promotes invasion and metastasis…”
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L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy by Jardim-Perassi, Bruna Victorasso, Irrera, Pietro, Oluwatola, Oluwaseyi E, Abrahams, Dominique, Estrella, Veronica C, Ordway, Bryce, Byrne, Samantha R, Ojeda, Andrew A, Whelan, Christopher J, Kim, Jongphil, Beatty, Matthew S, Damgaci-Erturk, Sultan, Longo, Dario Livio, Gaspar, Kim J, Siegers, Gabrielle M, Centeno, Barbara A, Lau, Justin Y C, Pilon-Thomas, Shari A, Ibrahim-Hashim, Arig, Gillies, Robert J

“…Acidosis is an important immunosuppressive mechanism that leads to tumor growth. Therefore, we investigated the neutralization of tumor acidity to improve…”
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A Mammaglobin-A Targeting Agent for Noninvasive Detection of Breast Cancer Metastasis in Lymph Nodes by TAFRESHI, Narges K, ENKEMANN, Steven A, GILLIES, Robert J, MORSE, David L, BUI, Marilyn M, LLOYD, Mark C, ABRAHAMS, Dominique, HUYNH, Amanda S, KIM, Jongphil, GROBMYER, Stephen R, CARTER, W. Bradford, VAGNER, Josef

“…Pathologic axillary lymph node (ALN) status is an important prognostic factor for staging breast cancer. Currently, status is determined by histopathology…”
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Abstract 3773: Investigating the tumor-host evolutionary arms race as a possible strategy for cancer therapy by Hashim, Arig A. Ibrahim, Abrahams, Dominique, Luddy, Kim, Gillies, Robert, Richards, Christina L., Brown, Joel, Gatenby, Robert

“…Abstract As first proposed by Cairns and Nowell more than 60 years ago, cancer is a Darwinian process so that cancer progression and resistance to therapy are…”
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Abstract 1140: A new twist on an old strategy: Can the lymph node environment help cancers escape immune surveillance by Estrella, Veronica, Swietach, Pawel, Luddy, Kim, Abrahams, Dominique, Enriquez-Navas, Pedro, Reshetnyak, Yana, Damaghi, Mehdi, Gillies, Robert J.

“…Abstract Cancer cells are selected for strategies to proliferate, invade, and metastasize within an organism. One such strategy is an ability to create an…”
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Abstract 375: Lipogenic phenotype is an adaptation to nutrient stress in the tumor microenvironment by Griffith, Crystal, Abrahams, Dominique, Ortiz, Antonio, Tassielli, Alexandra, Johnson, Joseph, Gatenby, Robert, Pillai, Smitha

“…Abstract The nutrient and oxygen poor microenvironment combined with acidosis arising from fermentative metabolism imparts strong selection pressure on cancer…”
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Abstract 2772: Targeting hypoxic habitats with hypoxia pro-drug evofosfamide in preclinical models of sarcoma by Perassi, Bruna Victorasso Jardim, Mu, Wei, Abrahams, Dominique F., Tomaszewski, Michal R., Poleszczuk, Jan, Higgins, Jack, Martinez, Gary V., Gillies, Robert J.

“…Abstract Tumor habitats are phenotypically and spatially distinct intratumoral regions. Hypoxic habitats are associated with reduced accessibility of…”
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Abstract 2929: Exploratory evolved strategies that limit cancer growth for possible new therapeutic strategies by Abrahams, Dominique, Hashim, Arig Ibrahim, Luddy, Kim, Gillies, Robert, Gatenby, Robert, Brown, Joel

“…Abstract Strong selection can promote mammalian evolution of a remarkably diverse phenotypic range over a short period of time. With appropriate selection…”
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Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities by Ordway, Bryce, Tomaszewski, Michal, Byrne, Samantha, Abrahams, Dominique, Swietach, Pawel, Gillies, Robert J, Damaghi, Mehdi

“…Evolutionary dynamics can be used to control cancers when a cure is not clinically considered to be achievable. Understanding Darwinian intratumoral…”
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Abstract 1231: Improving survival in pancreatic cancer using Doxorubicin in combination with L-DOS47 by Damgaci, Sultan, Chao, Heman, Uger, Marni D., Ibrahim-Hashim, Arig, Kim, Eunjung, Enriquez-Navas, Pedro Pedro M., Abrahams, Dominique, Anderson, Alexander R., Guvenis, Albert, Gillies, Robert J.

“…Abstract BACKGROUND: The tumor microenvironment is acidic, which inhibits the activity of weakly basic drugs such as doxorubicin. In order to test whether…”
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Acidity suppresses T cell function and increases memory T cell development by Wu, Hao, Estrella, Veronica, Enriquez‐Navas, Pedro, Abrahams, Dominique, Ibrahim‐Hashim, Arig, Luddy, Kimberly, Damaghi, Mehdi, RavindranadhanPillai, Smitha, Pilon‐Thomas, Shari, Swietach, Pawel, Gillies, Robert

“…Acidity is a common microenvironmental factor in solid tumors. We and others have observed that mild acidosis (pH ~6.6) can inhibit the interferon‐γ (IFN‐γ)…”
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Lymph nodes harbor compartments of substantial acidity by Swietach, Pawel, Wu, Hao, Estrella, Veronica, Enriquez‐Navas, Pedro, Abrahams, Dominique, Ibrahim‐Hashim, Arig, Reshetnyak, Yana, Luddy, Kimberly, Damaghi, Mehdi, Pilon‐Thomas, Shari, Gillies, Robert J

“…The effector function of T cells (e.g. secretion of cytokines) is profoundly inhibited by low extracellular pH (pHe), such as that encountered in solid tumors…”
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