Search Results - "Abraham, R. T."

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming by Eng, C H, Abraham, R T

“…Tumorigenesis is often accompanied by metabolic changes that favor rapid energy production and increased biosynthetic capabilities. These metabolic adaptations…”
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Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening by Strohecker, A M, Joshi, S, Possemato, R, Abraham, R T, Sabatini, D M, White, E

“…Deregulation of autophagy has been linked to multiple degenerative diseases and cancer, thus the identification of novel autophagy regulators for potential…”
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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism by Gingras, A C, Gygi, S P, Raught, B, Polakiewicz, R D, Abraham, R T, Hoekstra, M F, Aebersold, R, Sonenberg, N

“…The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5' end of mRNA. The eIF4F subunit eIF4E interacts…”
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A role for ATR in the DNA damage-induced phosphorylation of p53 by Tibbetts, R S, Brumbaugh, K M, Williams, J M, Sarkaria, J N, Cliby, W A, Shieh, S Y, Taya, Y, Prives, C, Abraham, R T

“…Phosphorylation at Ser-15 may be a critical event in the up-regulation and functional activation of p53 during cellular stress. In this report we provide…”
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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002 by Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence, J. C., Abraham, R. T.

“…The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian target of rapamycin (mTOR). The…”
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A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells by SEKULIC, A, HUDSON, C. C, HOMME, J. L, PENG YIN, OTTERNESS, D. M, KARNITZ, L. M, ABRAHAM, R. T

“…The microbially derived antiproliferative agent rapamycin inhibits cell growth by interfering with the signaling functions of the mammalian target of rapamycin…”
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Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine by SARKARIA, J. N, BUSBY, E. C, TIBBETTS, R. S, ROOS, P, TAYA, Y, KARNITZ, L. M, ABRAHAM, R. T

“…Caffeine exposure sensitizes tumor cells to ionizing radiation and other genotoxic agents. The radiosensitizing effects of caffeine are associated with the…”
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The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1 by BUSBY, E. C, LEISTRITZ, D. F, ABRAHAM, R. T, KARNITZ, L. M, SARKARIA, J. N

“…The investigational anticancer agent 7-hydroxystaurosporine (UCN-01) abrogates the G2 checkpoint in tumor cells and sensitizes them to the lethal effects of…”
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Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent Wortmannin by SARKARIA, J. N, TIBBETTS, R. S, BUSBY, E. C, KENNEDY, A. P, HILL, D. E, ABRAHAM, R. T

“…Members of the phosphatidylinositol-3 kinase related kinase (PIKK) family function in both cell cycle progression and DNA damage-induced cell cycle…”
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Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin by Brunn, Gregory J., Hudson, Christine C., Sekulić, Aleksandar, Williams, Josie M., Hosoi, Hajime, Houghton, Peter J., Lawrence, John C., Abraham, Robert T.

“…The immunosuppressant rapamycin interferes with G$_1$-phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of…”
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Visco-elastic and Dielectric Relaxation Studies of Crude Oil by George, A. K., Singh, R. N., Abraham, R. T., Arafin, S., Al-Balushi, M.

“…Temperature-dependent dielectric and viscosity studies have been carried out in two samples of crude oils procured from different wells of Oman oil fields. The…”
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Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells by HOSOI, H, DILLING, M. B, SHIKATA, T, LIU, L. N, SHU, L, ASHMUN, R. A, GERMAIN, G. S, ABRAHAM, R. T, HOUGHTON, P. J

“…The mammalian target of rapamycin (mTOR) has been shown to link growth factor signaling and posttranscriptional control of translation of proteins that are…”
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Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events by SECRIST, J. P, BURNS, L. A, KARNITZ, L, KORETZKY, G. A, ABRAHAM, R. T

“…Ligation of the multimeric T-cell antigen receptor complex (TCR) triggers a pleiotropic cellular activation response that includes lymphokine secretion,…”
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Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway by Karnitz, Larry M., Burns, Leigh Ann, Sutor, Shari L., Blenis, John, Abraham, Robert T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PI 3-kinase related kinases: ‘big’ players in stress-induced signaling pathways by Abraham, Robert T.

“…The phosphoinositide 3-kinase related kinases (PIKKs) comprise a family of high molecular mass signaling proteins that play central roles in the control of…”
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Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes by Morice, W.G., Wiederrecht, G, Brunn, G.J., Siekierka, J.J., Abraham, R.T.

“…The immunosuppressant rapamycin (RAP) is a potent inhibitor of the entry of interleukin (IL)-2-stimulated T cells into S-phase. Earlier results indicated that…”
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Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases by Abraham, R T, Acquarone, M, Andersen, A, Asensi, A, Bellé, R, Berger, F, Bergounioux, C, Brunn, G, Buquet-Fagot, C, Fagot, D

“…Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle…”
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T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1 by Secrist, J P, Karnitz, L, Abraham, R T

“…Ligand-mediated perturbation of the T-cell antigen receptor (TCR) triggers a rapid increase in phosphoinositide-specific phospholipase C (PLC) activity in…”
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Cell cycle checkpoint signaling through the ATM and ATR kinases by Abraham, R T

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Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line by Karnitz, L, Sutor, S L, Torigoe, T, Reed, J C, Bell, M P, McKean, D J, Leibson, P J, Abraham, R T

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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