Search Results - "Abraham, Jean E"

Multi-omic machine learning predictor of breast cancer therapy response by Sammut, Stephen-John, Crispin-Ortuzar, Mireia, Chin, Suet-Feung, Provenzano, Elena, Bardwell, Helen A., Ma, Wenxin, Cope, Wei, Dariush, Ali, Dawson, Sarah-Jane, Abraham, Jean E., Dunn, Janet, Hiller, Louise, Thomas, Jeremy, Cameron, David A., Bartlett, John M. S., Hayward, Larry, Pharoah, Paul D., Markowetz, Florian, Rueda, Oscar M., Earl, Helena M., Caldas, Carlos

“…Breast cancers are complex ecosystems of malignant cells and the tumour microenvironment 1 . The composition of these tumour ecosystems and interactions within…”
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Precision Breast Cancer Medicine: Early Stage Triple Negative Breast Cancer-A Review of Molecular Characterisation, Therapeutic Targets and Future Trends by Pinilla, Karen, Drewett, Lynsey M, Lucey, Rebecca, Abraham, Jean E

“…Personalised approaches to the management of all solid tumours are increasing rapidly, along with wider accessibility for clinicians. Advances in tumour…”
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NRG1 fusions in breast cancer by Howarth, Karen D, Mirza, Tashfina, Cooke, Susanna L, Chin, Suet-Feung, Pole, Jessica C, Turro, Ernest, Eldridge, Matthew D, Garcia, Raquel Manzano, Rueda, Oscar M, Boursnell, Chris, Abraham, Jean E, Caldas, Carlos, Edwards, Paul A W

“…NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors. The NRG1 gene…”
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Six versus 12 months' adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT by Earl, Helena, Hiller, Louise, Vallier, Anne-Laure, Loi, Shrushma, McAdam, Karen, Hughes-Davies, Luke, Rea, Daniel, Howe, Donna, Raynes, Kerry, Higgins, Helen B, Wilcox, Maggie, Plummer, Chris, Mahler-Araujo, Betania, Provenzano, Elena, Chhabra, Anita, Gasson, Sophie, Balmer, Claire, Abraham, Jean E, Caldas, Carlos, Hall, Peter, Shinkins, Bethany, McCabe, Christopher, Hulme, Claire, Miles, David, Wardley, Andrew M, Cameron, David A, Dunn, Janet A

“…The addition of adjuvant trastuzumab to chemotherapy has significantly improved outcomes for people with human epidermal growth factor receptor 2…”
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The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study by Dorling, Leila, Kar, Siddhartha, Michailidou, Kyriaki, Hiller, Louise, Vallier, Anne-Laure, Ingle, Susan, Hardy, Richard, Bowden, Sarah J, Dunn, Janet A, Twelves, Chris, Poole, Christopher J, Caldas, Carlos, Earl, Helena M, Pharoah, Paul D P, Abraham, Jean E

“…Ninety-four common genetic variants are confirmed to be associated with breast cancer. This study tested the hypothesis that breast cancer susceptibility…”
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Common Polymorphisms in the Prostaglandin Pathway Genes and Their Association with Breast Cancer Susceptibility and Survival by ABRAHAM, Jean E, HARRINGTON, Patricia, DRIVER, Kristy E, TYRER, Jonathan, EASTON, Douglas F, DUNNING, Alison M, PHAROAH, Paul D. P

“…Purpose: There is evidence that genetic variation in the prostaglandin pathway affects cancer susceptibility and progression. Conflicting data from several…”
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Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping by Abraham, Jean E, Maranian, Mel J, Spiteri, Inmaculada, Russell, Roslin, Ingle, Susan, Luccarini, Craig, Earl, Helena M, Pharoah, Paul P D, Dunning, Alison M, Caldas, Carlos

“…The increasing trend for incorporation of biological sample collection within clinical trials requires sample collection procedures which are convenient and…”
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Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel by ABRAHAM, Jean E, QI GUO, BOWDEN, Sarah J, DUNN, Janet A, POOLE, Christopher J, CALDAS, Carlos, PHAROAH, Paul P. D, EARL, Helena M, DORLING, Leila, TYRER, Jonathan, INGLE, Susan, HARDY, Richard, VALLIER, Anne-Laure, HILLER, Louise, BURNS, Russell, JONES, Linda

“…Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few have been…”
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Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients by Woitek, Ramona, McLean, Mary A, Ursprung, Stephan, Rueda, Oscar M, Manzano Garcia, Raquel, Locke, Matthew J, Beer, Lucian, Baxter, Gabrielle, Rundo, Leonardo, Provenzano, Elena, Kaggie, Joshua, Patterson, Andrew, Frary, Amy, Field-Rayner, Johanna, Papalouka, Vasiliki, Kane, Justine, Benjamin, Arnold J V, Gill, Andrew B, Priest, Andrew N, Lewis, David Y, Russell, Roslin, Grimmer, Ashley, White, Brian, Latimer-Bowman, Beth, Patterson, Ilse, Schiller, Amy, Carmo, Bruno, Slough, Rhys, Lanz, Titus, Wason, James, Schulte, Rolf F, Chin, Suet-Feung, Graves, Martin J, Gilbert, Fiona J, Abraham, Jean E, Caldas, Carlos, Brindle, Kevin M, Sala, Evis, Gallagher, Ferdia A

“…Hyperpolarized C-MRI is an emerging tool for probing tissue metabolism by measuring C-label exchange between intravenously injected hyperpolarized [1-…”
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The PARTNER trial of neoadjuvant olaparib with chemotherapy in triple-negative breast cancer by Abraham, Jean E., Pinilla, Karen, Dayimu, Alimu, Grybowicz, Louise, Demiris, Nikolaos, Harvey, Caron, Drewett, Lynsey M., Lucey, Rebecca, Fulton, Alexander, Roberts, Anne N., Worley, Joanna R., Chhabra, Anita, Qian, Wendi, Vallier, Anne-Laure, Hardy, Richard M., Chan, Steve, Hickish, Tamas, Tripathi, Devashish, Venkitaraman, Ramachandran, Persic, Mojca, Aslam, Shahzeena, Glassman, Daniel, Raj, Sanjay, Borley, Annabel, Braybrooke, Jeremy P., Sutherland, Stephanie, Staples, Emma, Scott, Lucy C., Davies, Mark, Palmer, Cheryl A., Moody, Margaret, Churn, Mark J., Newby, Jacqueline C., Mukesh, Mukesh B., Chakrabarti, Amitabha, Roylance, Rebecca R., Schouten, Philip C., Levitt, Nicola C., McAdam, Karen, Armstrong, Anne C., Copson, Ellen R., McMurtry, Emma, Tischkowitz, Marc, Provenzano, Elena, Earl, Helena M.

“…PARTNER is a prospective, phase II–III, randomized controlled clinical trial that recruited patients with triple-negative breast cancer 1 , 2 , who were…”
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Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer by Ali, H Raza, Dariush, Aliakbar, Provenzano, Elena, Bardwell, Helen, Abraham, Jean E, Iddawela, Mahesh, Vallier, Anne-Laure, Hiller, Louise, Dunn, Janet A, Bowden, Sarah J, Hickish, Tamas, McAdam, Karen, Houston, Stephen, Irwin, Mike J, Pharoah, Paul D P, Brenton, James D, Walton, Nicholas A, Earl, Helena M, Caldas, Carlos

“…There is a need to improve prediction of response to chemotherapy in breast cancer in order to improve clinical management and this may be achieved by…”
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Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation by Mason, Bethany, Flach, Susanne, Teixeira, Felipe R., Manzano Garcia, Raquel, Rueda, Oscar M., Abraham, Jean E., Caldas, Carlos, Edwards, Paul A. W., Laman, Heike

“…In cancer, many genes are mutated by genome rearrangement, but our understanding of the functional consequences of this remains rudimentary. Here we report the…”
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Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer by Santonja, Angela, Cooper, Wendy N, Eldridge, Matthew D, Edwards, Paul A W, Morris, James A, Edwards, Abigail R, Zhao, Hui, Heider, Katrin, Couturier, Dominique‐Laurent, Vijayaraghavan, Aadhitthya, Mennea, Paulius, Ditter, Emma‐Jane, Smith, Christopher G, Boursnell, Chris, Manzano García, Raquel, Rueda, Oscar M, Beddowes, Emma, Biggs, Heather, Sammut, Stephen‐John, Rosenfeld, Nitzan, Caldas, Carlos, Abraham, Jean E, Gale, Davina

“…Analysis of circulating tumor DNA (ctDNA) to monitor cancer dynamics and detect minimal residual disease has been an area of increasing interest. Multiple…”
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A Bayesian adaptive design for biomarker trials with linked treatments by Wason, James M S, Abraham, Jean E, Baird, Richard D, Gournaris, Ioannis, Vallier, Anne-Laure, Brenton, James D, Earl, Helena M, Mander, Adrian P

“…Background: Response to treatments is highly heterogeneous in cancer. Increased availability of biomarkers and targeted treatments has led to the need for…”
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A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities by Abraham, Jean E, Hiller, Louise, Dorling, Leila, Vallier, Anne-Laure, Dunn, Janet, Bowden, Sarah, Ingle, Susan, Jones, Linda, Hardy, Richard, Twelves, Christopher, Poole, Christopher J, Pharoah, Paul D P, Caldas, Carlos, Earl, Helena M

“…The relationship between chemotherapy-related toxicities and prognosis is unclear. Previous studies have examined the association of myelosuppression…”
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CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen by Abraham, Jean E, Maranian, Mel J, Driver, Kristy E, Platte, Radka, Kalmyrzaev, Bolot, Baynes, Caroline, Luccarini, Craig, Shah, Mitul, Ingle, Susan, Greenberg, David, Earl, Helena M, Dunning, Alison M, Pharoah, Paul D P, Caldas, Carlos

“…Tamoxifen is one of the most effective adjuvant breast cancer therapies available. Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6),…”
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Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel--response by Guo, Qi, Abraham, Jean E, Caldas, Carlos, Earl, Helena M, Pharoah, Paul P D

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Hyperpolarized 13 C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer by Woitek, Ramona, McLean, Mary A, Gill, Andrew B, Grist, James T, Provenzano, Elena, Patterson, Andrew J, Ursprung, Stephan, Torheim, Turid, Zaccagna, Fulvio, Locke, Matthew, Laurent, Marie-Christine, Hilborne, Sarah, Frary, Amy, Beer, Lucian, Rundo, Leonardo, Patterson, Ilse, Slough, Rhys, Kane, Justine, Biggs, Heather, Harrison, Emma, Lanz, Titus, Basu, Bristi, Baird, Richard, Sala, Evis, Graves, Martin J, Gilbert, Fiona J, Abraham, Jean E, Caldas, Carlos, Brindle, Kevin M, Gallagher, Ferdia A

“…To compare hyperpolarized carbon 13 ( C) MRI with dynamic contrast material-enhanced (DCE) MRI in the detection of early treatment response in breast cancer…”
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Hyperpolarized 13C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer by Woitek, Ramona, McLean, Mary A, Gill, Andrew B, Grist, James T, Provenzano, Elena, Patterson, Andrew J, Ursprung, Stephan, Torheim, Turid, Zaccagna, Fulvio, Locke, Matthew, Laurent, Marie-Christine, Hilborne, Sarah, Frary, Amy, Beer, Lucian, Rundo, Leonardo, Patterson, Ilse, Slough, Rhys, Kane, Justine, Biggs, Heather, Harrison, Emma, Lanz, Titus, Basu, Bristi, Baird, Richard, Sala, Evis, Graves, Martin J, Gilbert, Fiona J, Abraham, Jean E, Caldas, Carlos, Brindle, Kevin M, Gallagher, Ferdia A

“…PurposeTo compare hyperpolarized carbon 13 (13C) MRI with dynamic contrast material-enhanced (DCE) MRI in the detection of early treatment response in breast…”
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CYP2D6 Gene Variants and Their Association with Breast Cancer Susceptibility by ABRAHAM, Jean E, MARANIAN, Mel J, CALDAS, Carlos, DRIVER, Kristy E, PLATTE, Radka, KALMYRZAEV, Bolot, BAYNES, Caroline, LUCCARINI, Craig, EARL, Helena M, DUNNING, Alison M, PHAROAH, Paul D. P

“…The gene encoding the phase I enzyme cytochrome P4502D6 (CYP2D6) has been previously investigated for its potential predictive role in the efficacy of breast…”
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