Search Results - "About, Ghina Bou"
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Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions
Published in Scientific reports (24-10-2017)“…Hepatocellular carcinoma (HCC) is the only cancer for which non-invasive diagnosis is recognized by international guidelines. Contrast agent free ultrasound…”
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HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models
Published in The Journal of clinical investigation (15-04-2022)“…Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are responsible for rare human developmental disorders known as RASopathies…”
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Physiological Expression of AMPKγ2 Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice
Published in The Journal of biological chemistry (01-11-2016)“…Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2NI) and R531G (AMPKγ2RG), are associated with Wolff-Parkinson-White (WPW)…”
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Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice
Published in Scientific reports (14-10-2016)“…The development of multimodal strategies for the treatment of hepatocellular carcinoma requires tractable animal models allowing for advanced in vivo imaging…”
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An innovative combined immunization platform for personalized cancer immunotherapy
Published in Journal of clinical oncology (20-05-2019)“…Abstract only e14225 Background: Activity of immune checkpoint inhibitors relies mainly on the presence of an immune response directed against neoantigens…”
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New models for human disease from the International Mouse Phenotyping Consortium
Published in Mammalian genome (01-06-2019)“…The International Mouse Phenotyping Consortium (IMPC) continues to expand the catalogue of mammalian gene function by conducting genome and phenome-wide…”
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Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice
Published in Mammalian genome (01-06-2023)“…Reference ranges provide a powerful tool for diagnostic decision-making in clinical medicine and are enormously valuable for understanding normality in…”
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Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice
Published in The Journal of biological chemistry (04-11-2016)“…Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2NI) and R531G (AMPKγ2RG), are associated with Wolff-Parkinson-White (WPW)…”
Get full text
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