Search Results - "Abourehab, Mohammed A. S"
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Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Published in Molecular cancer (12-01-2023)“…Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising…”
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2
Gold nanoparticles and gold nanorods in the landscape of cancer therapy
Published in Molecular cancer (21-06-2023)“…Cancer is a grievous disease whose treatment requires a more efficient, non-invasive therapy, associated with minimal side effects. Gold nanoparticles…”
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3
Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer
Published in Molecular cancer (12-01-2023)“…Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor prognosis can be attributed to both troublesome detections at the…”
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4
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
Published in Scientific reports (27-12-2022)“…The inhibitory action of fifteen benzyloxy ortho / para -substituted chalcones ( B1-B15 ) was evaluated against human monoamine oxidases (hMAOs). All the…”
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Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity
Published in Scientific reports (27-07-2022)“…Currently, the humanity is in a fierce battle against various health-related challenges especially those associated with human malignancies. This created the…”
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Dostarlimab as a Miracle Drug: Rising Hope against Cancer Treatment
Published in Biosensors (Basel) (08-08-2022)“…Immunotherapy is one of the four pillars of cancer treatment that has recently emerged as a beacon of hope for cancer patients. Certain immunotherapies, for…”
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Influence of selected non-antibiotic pharmaceuticals on antibiotic resistance gene transfer in Escherichia coli
Published in PloS one (21-06-2024)“…Antibiotic resistance genes (ARGs) transfer rapidly among bacterial species all over the world contributing to the aggravation of antibiotic resistance crisis…”
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Advancements in Polymeric Nanocarriers to Mediate Targeted Therapy against Triple-Negative Breast Cancer
Published in Pharmaceutics (01-11-2022)“…Triple-negative breast cancer (TNBC) is a destructive disease with a poor prognosis, low survival rate and high rate of metastasis. It comprises 15% of total…”
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Development a novel robust method to enhance the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug based on machine-learning
Published in Scientific reports (30-07-2022)“…Accurate specification of the drugs’ solubility is known as an important activity to appropriately manage the supercritical impregnation process. Over the last…”
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Ultrasound Assisted Synthesis and In Silico Modelling of 1,2,4-Triazole Coupled Acetamide Derivatives of 2-(4-Isobutyl phenyl)propanoic acid as Potential Anticancer Agents
Published in Molecules (Basel, Switzerland) (01-11-2022)“…The development of an economical method for the synthesis of biologically active compounds was the major goal of this research. In the present study, we have…”
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Design of predictive model to optimize the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug
Published in Scientific reports (30-07-2022)“…These days, many efforts have been made to increase and develop the solubility and bioavailability of novel therapeutic medicines. One of the most believable…”
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12
A Novel Curcumin Arginine Salt: A Solution for Poor Solubility and Potential Anticancer Activities
Published in Molecules (Basel, Switzerland) (28-12-2022)“…Curcumin is a natural polyphenolic compound with well-known anticancer properties. Poor solubility and permeability hamper its use as an anticancer…”
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13
Design, Formulation, and Characterization of Valsartan Nanoethosomes for Improving Their Bioavailability
Published in Pharmaceutics (24-10-2022)“…The objective of this study was to formulate and evaluate valsartan (VLT) ethosomes to prepare an optimized formula of VLT-entrapped ethosomes that could be…”
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14
Solubility Optimization of Loxoprofen as a Nonsteroidal Anti-Inflammatory Drug: Statistical Modeling and Optimization
Published in Molecules (Basel, Switzerland) (01-07-2022)“…Industrial-based application of supercritical CO (SCCO ) has emerged as a promising technology in numerous scientific fields due to offering brilliant…”
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15
In Silico Study for Algerian Essential Oils as Antimicrobial Agents against Multidrug-Resistant Bacteria Isolated from Pus Samples
Published in Antibiotics (Basel) (27-09-2022)“…In the context of the globally growing problem of resistance to most used antibacterial agents, essential oils offer promising solutions against…”
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Development of GBRT Model as a Novel and Robust Mathematical Model to Predict and Optimize the Solubility of Decitabine as an Anti-Cancer Drug
Published in Molecules (Basel, Switzerland) (01-09-2022)“…The efficient production of solid-dosage oral formulations using eco-friendly supercritical solvents is known as a breakthrough technology towards developing…”
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Computational simulation and target prediction studies of solubility optimization of decitabine through supercritical solvent
Published in Scientific reports (07-11-2022)“…Computational analysis of drug solubility was carried out using machine learning approach. The solubility of Decitabine as model drug in supercritical CO 2 was…”
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18
Natural resistance of tomato plants to Tomato yellow leaf curl virus
Published in Frontiers in plant science (19-12-2022)“…Tomato yellow leaf curl virus (TYLCV) is one of the most harmful afflictions in the world that affects tomato growth and production. Six regular antagonistic…”
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Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment
Published in Pharmaceuticals (Basel, Switzerland) (01-02-2023)“…In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on…”
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Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
Published in Pharmaceuticals (Basel, Switzerland) (16-09-2022)“…Two series of dimethoxy-halogenated chalcones (DM1−DM20) were synthesized and tested for their ability to inhibit monoamine oxidase (MAOs). Compound DM2…”
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