Search Results - "Aboud, Heba"

Surface modified niosomes of olanzapine for brain targeting via nasal route; preparation, optimization, and in vivo evaluation by Khallaf, Rasha A., Aboud, Heba M., Sayed, Ossama M.

“…Olanzapine (OL) is an atypical antipsychotic drug which suffers from an extensive hepatic metabolism and poor bioavailability. In addition, it has low brain…”
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A Novel Chitosan-coated Leciplex Loaded with Ambrisentan as a Possible Pulmonary Nanosystem: Optimization, Characterization, and Pharmacokinetics Assessments by Eid, Hussein M, Turkia, Toqa H, Ali, Adel A, Aboud, Heba M

“…The purpose of this research was to formulate, optimize, and characterize ambrisentan chitosan-coated LeciPlex (AMS-CTS-LPX) to increase the therapeutic…”
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Nanotransfersomes of carvedilol for intranasal delivery: formulation, characterization and in vivo evaluation by Aboud, Heba M, Ali, Adel Ahmed, El-Menshawe, Shahira F, Elbary, Ahmed Abd

“…Development of carvedilol-loaded transfersomes for intranasal administration to overcome poor nasal permeability and hepatic first pass effect so as to enhance…”
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Transdermal delivery of atorvastatin calcium from novel nanovesicular systems using polyethylene glycol fatty acid esters: Ameliorated effect without liver toxicity in poloxamer 407-induced hyperlipidemic rats by Mahmoud, Mohamed O., Aboud, Heba M., Hassan, Amira H., Ali, Adel A., Johnston, Thomas P.

“…Atorvastatin calcium (ATV), a cholesterol-lowering agent, suffers from poor systemic availability (14%) after oral administration in addition to other side…”
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Preparation and appraisal of self-assembled valsartan-loaded amalgamated Pluronic F127/Tween 80 polymeric micelles: Boosted cardioprotection via regulation of Mhrt/Nrf2 and Trx1 pathways in cisplatin-induced cardiotoxicity by Aboud, Heba M., Mahmoud, Mohamed O., Abdeltawab Mohammed, Marwa, Shafiq Awad, Mohammad, Sabry, Dina

“…This study aimed to develop valsartan (VAL)-loaded mixed micelles and investigate their cardioprotective potential and molecular mechanisms through Mhrt/Nrf2…”
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Novel in situ gelling vaginal sponges of sildenafil citrate-based cubosomes for uterine targeting by Aboud, Heba M., Hassan, Amira H., Ali, Adel A., Abdel-Razik, Abdel-Razik H.

“…Sildenafil citrate (SIL), a type 5-specific phosphodiesterase inhibitor, demonstrates valuable results in the management of infertility in women; however, the…”
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A novel nanogel loaded with chitosan decorated bilosomes for transdermal delivery of terbutaline sulfate: artificial neural network optimization, in vitro characterization and in vivo evaluation by El Menshawe, Shahira F., Aboud, Heba M., Elkomy, Mohammed H., Kharshoum, Rasha M., Abdeltwab, Amany M.

“…The objective of the present work was to formulate, optimize, and evaluate transdermal terbutaline sulfate (TBN)-loaded bilosomes (BLS) in gel, compared to…”
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Response Surface Optimization of Ultra-Elastic Nanovesicles Loaded with Deflazacort Tailored for Transdermal Delivery: Accentuated Bioavailability and Anti-Inflammatory Efficacy by Ali, Adel A, Hassan, Amira H, Eissa, Essam M, Aboud, Heba M

“…The aim of the present study was to develop deflazacort (DFZ) ultra-elastic nanovesicles (UENVs) loaded gel for topical administration to evade…”
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Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway by El Menshawe, Shahira F., Nafady, Mohamed M., Aboud, Heba M., Kharshoum, Rasha M., Elkelawy, Asmaa Mohammed M. Hussein, Hamad, Doaa S.

“…The current study aimed to encapsulate fluvastatin sodium (FVS), a member of the statins family possessing pleiotropic effects in rheumatoid arthritis (RA),…”
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Plantago boissieri : Phytochemical Assessment, Antioxidant, Anti-inflammatoryand Wound Healing Potential by Amin, Elham, Abouzeid, Hala, Afifi, Naglaa, Aboud, Heba M, Abd El-Ghafar, Omnia A M, Alabdulrahim, Alya K, Ahmed, Hayam S

“…Plantago is a large genus under family Plantaginaceae. Plantago species were noted for potent antioxidant, anti-inflammatory and wound healing activities. The…”
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Development, Optimization, and Evaluation of Carvedilol-Loaded Solid Lipid Nanoparticles for Intranasal Drug Delivery by Aboud, Heba M., El komy, Mohammed H., Ali, Adel A., El Menshawe, Shahira F., Abd Elbary, Ahmed

“…Carvedilol, a beta-adrenergic blocker, suffers from poor systemic availability (25%) due to first-pass metabolism. The aim of this work was to improve…”
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Optimization and Appraisal of Nintedanib-Loaded Mixed Polymeric Micelles as a Potential Nanovector for Non-Invasive Pulmonary Fibrosis Mitigation by Aboud, Heba M, El Menshawe, Shahira F, Mohammed, Nada H, Tulbah, Alaa S, Ali, Adel A

“…Nintedanib (NTD), a triple tyrosine kinase receptor inhibitor, is the recommended first-line tackling option for idiopathic pulmonary fibrosis (IPF)…”
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Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation by Elkomy, Mohammed H., El Menshawe, Shahira F., Kharshoum, Rasha M., Abdeltwab, Amany M., Hussein, Raghda R. S., Hamad, Doaa S., Alsalahat, Izzeddin, Aboud, Heba M.

“…Asthma represents a globally serious non-communicable ailment with significant public health outcomes for both pediatrics and adults triggering vast morbidity…”
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Harnessing of Doxylamine Succinate/Pyridoxine Hydrochloride-Dual Laden Bilosomes as a Novel Combinatorial Nanoparadigm for Intranasal Delivery: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal by Salem, Heba F, Ali, Adel A, Hegazy, Amira M, Sadek, Abdel-Rahman A, Aboud, Heba M

“…The present work is concerned with tailoring and appraisal of a novel nano-cargo; bilosomes (BLS) dual laded with doxylamine succinate (DAS) and pyridoxine…”
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Intratracheally Inhalable Nifedipine-Loaded Chitosan-PLGA Nanocomposites as a Promising Nanoplatform for Lung Targeting: Snowballed Protection via Regulation of TGF-β/β-Catenin Pathway in Bleomycin-Induced Pulmonary Fibrosis by Elkomy, Mohammed H, Khallaf, Rasha A, Mahmoud, Mohamed O, Hussein, Raghda R S, El-Kalaawy, Asmaa M, Abdel-Razik, Abdel-Razik H, Aboud, Heba M

“…Pulmonary fibrosis is a serious ailment that may progress to lung remodeling and demolition, where the key participants in its incidence are fibroblasts…”
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An investigation of the acaricidal activity of benzyl alcohol on Rhipicephalus annulatus and Rhipicephalus sanguineus and its synergistic or antagonistic interaction with commonly used acaricides by Aboelhadid, Shawky M., Ibrahium, Samar M., Abdel‐Baki, Abdel‐Azeem S., Hassan, Khaled M., Arafa, Waleed M., Aboud, Heba M., Mohy, Sarah, Al‐Quraishy, Saleh, Hassan, Ahmed O., Abdelgelil, Noha H., Gadelhaq, Sahar M.

“…The most economically significant ectoparasites in the tropics and subtropics are ixodid ticks, especially Rhipicephalus annulatus and Rhipicephalus…”
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Tailoring of Selenium-Plated Novasomes for Fine-Tuning Pharmacokinetic and Tumor Uptake of Quercetin: In Vitro Optimization and In Vivo Radiobiodistribution Assessment in Ehrlich Tumor-Bearing Mice by Aboud, Heba M, Hussein, Amal K, Zayan, Abdallah Z, Makram, Tarek Saad, Sarhan, Mona O, El-Sharawy, Dina M

“…Quercetin (QRC) is a bioflavonoid with anti-inflammatory, antioxidant, and anticancer activities, yet QRC poor bioavailability has hampered its clinical…”
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Tunable Polymeric Mixed Micellar Nanoassemblies of Lutrol F127/Gelucire 44/14 for Oral Delivery of Praziquantel: A Promising Nanovector against Hymenolepis nana in Experimentally-Infected Rats by Arafa, Waleed M., Elkomy, Mohammed H., Aboud, Heba M., Ali, Mona Ibrahim, Abdel Gawad, Samah S., Aboelhadid, Shawky M., Mahdi, Emad A., Alsalahat, Izzeddin, Abdel-Tawab, Heba

“…Hymenolepiasis represents a parasitic infection of common prevalence in pediatrics with intimidating impacts, particularly amongst immunocompromised patients…”
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Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis by El Menshawe, Shahira F., Shalaby, Khaled, Elkomy, Mohammed H., Aboud, Heba M., Ahmed, Yasmin M., Abdelmeged, Abdelmeged A., Elkarmalawy, Marwa, Abou Alazayem, Mahmoud A., El Sisi, Amani M.

“…Celecoxib (CLX), a selective inhibitor for cyclooxygenase 2 (COX-2), has manifested potential activity against diverse types of cancer. However, low…”
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Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation by El-Nabarawi, Mohamed A, Ali, Adel A, Aboud, Heba M, Hassan, Amira H, Godah, Amany H

“…Betahistine dihydrochloride (BH.2HCl), an anti-vertigo histamine analog used in the treatment of Ménière's disease, undergoes extensive first-pass metabolism…”
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