Search Results - "Aboraia, Ahmed S."

Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors by Abdel-Hafez, Gehan A., Mohamed, Abdel-Maaboud I., Youssef, Adel F., Simons, Claire, Aboraia, Ahmed S.

“…Topoisomerase (IIB) inhibitors have been involved in the therapies of tumour progression and have become a major focus for the development of anticancer…”
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Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors by Mohamed, Mamdouh F.A., Youssif, Bahaa G.M., Shaykoon, Montaser Sh. A., Abdelrahman, Mostafa H., Elsadek, Bakheet E.M., Aboraia, Ahmed S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •12 novel compounds contain Tetrahydrobenzo[4,5]Thieno[2,3-d]pyrimidinone as a novel cap group, attached to ZBG via aliphatic, aralkyl or…”
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Effects of Lidocaine-Derived Organic Compounds on Eosinophil Activation and Survival by Shin, Seung-Heon, Ye, Mi-Kyung, Chae, Mi-Hyun, Geum, Sang-Yen, Aboraia, Ahmed S, Abdel-Aal, Abu-Baker M, Qayed, Wesam S, Abd El-Wahab, Hend A A, Abou-Ghadir, Ola F, Aboul-Fadl, Tarek

“…Lidocaine, a local anesthetic, is known to possess anti-inflammatory properties. However, its clinical use is limited by inconveniences, such as its local…”
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Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents by Hussein, Essam M., Alsantali, Reem I., Morad, Moataz, Obaid, Rami J., Altass, Hatem M., Sayqal, Ali, Abourehab, Mohamed A. S., Elkhawaga, Amal A., Aboraia, Ahmed S. M., Ahmed, Saleh A.

“…Background Thiazoles, thiazolidinones and azetidinones are highly ranked amongst natural and synthetic heterocyclic derivatives due to their great…”
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N4-Substituted Piperazinyl Norfloxacin Derivatives with Broad-Spectrum Activity and Multiple Mechanisms on Gyrase, Topoisomerase IV, and Bacterial Cell Wall Synthesis by Kamal El-sagheir, Ahmed M., Abdelmesseh Nekhala, Ireny, Abd El-Gaber, Mohammed K., Aboraia, Ahmed S., Persson, Jonatan, Schäfer, Ann-Britt, Wenzel, Michaela, Omar, Farghaly A.

“…Fluoroquinolones are an important class of antibiotics with broad-spectrum antibacterial and antitubercular activity. Here, we describe the design and…”
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Anti-Allergic and Anti-Inflammatory Effects of Lidocaine-Derived Organic Compounds in a House Dust Mite-Induced Allergic Rhinitis Mouse Model by Shin, Seung-Heon, Ye, Mi-Kyung, Chae, Mi-Hyun, Geum, Sang-Yen, Aboraia, Ahmed S, Abdel-Aal, Abu-Baker M, Qayed, Wesam S, El-Wahab, Hend A A Abd, Abou-Ghadir, Ola F, Aboul-Fadl, Tarek

“…Allergic rhinitis (AR) is a common chronic disease that significantly impacts the quality of life. Lidocaine is known to have anti-inflammatory and…”
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Design, Synthesis, Molecular Modeling, Biological Activity, and Mechanism of Action of Novel Amino Acid Derivatives of Norfloxacin by Kamal El-sagheir, Ahmed M., Abdelmesseh Nekhala, Ireny, Abd El-Gaber, Mohammed K., Aboraia, Ahmed S., Persson, Jonatan, Schäfer, Ann-Britt, Wenzel, Michaela, Omar, Farghaly A.

“…Two series of N4-substituted piperazinyl amino acid derivatives of norfloxacin (24 new compounds) were designed and synthesized to attain structural surrogates…”
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Small Molecule Inhibitors of Retinoic Acid 4-Hydroxylase (CYP26): Synthesis and Biological Evaluation of Imidazole Methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates by Gomaa, Mohamed S, Bridgens, Caroline E, Aboraia, Ahmed S, Veal, Gareth J, Redfern, Christopher P. F, Brancale, Andrea, Armstrong, Jane L, Simons, Claire

“…The synthesis and potent inhibitory activity of novel imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates in a MCF-7 CYP26A1 microsomal assay is…”
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Synthesis, theoretical investigations, biocidal screening, DNA binding, in vitro cytotoxicity and molecular docking of novel Cu (II), Pd (II) and Ag (I) complexes of chlorobenzylidene Schiff base: Promising antibiotic and anticancer agents by Abdel‐Rahman, Laila H., Adam, Mohamed Shaker S., Abu‐Dief, Ahmed M., Moustafa, H., Basha, Maram T., Aboraia, Ahmed S., Al‐Farhan, Badriah Saad, Ahmed, Hanan El‐Sayed

“…Three new Cu (II), Pd (II) and Ag (I) complexes of bidentate Schiff base ligand 2‐[(4‐chlorobenzylidene)amino] phenol (HL) were synthesized. The stoichiometric…”
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Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV by Hofny, Heba A., Mohamed, Mamdouh F.A., Gomaa, Hesham A.M., Abdel-Aziz, Salah A., Youssif, Bahaa G.M., El-koussi, Nawal A., Aboraia, Ahmed S.

“…[Display omitted] •A series of novel quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids has been designed and synthesized.•The new hybrids were…”
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Fatty Acid Conjugated Chalcones as Tubulin Polymerization Inhibitors: Design, Synthesis, QSAR, and Apoptotic and Antiproliferative Activity by Mohamed, Samia M., Abou-Ghadir, Ola M. Fahmy, El-Mokhtar, Mohamed A., Aboraia, Ahmed S., Abdel−Aal, Abu-Baker M.

“…Cancer is often associated with an aberrant increase in tubulin and microtubule activity required for cell migration, invasion, and metastasis. A new series of…”
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Design, synthesis and pharmacophoric model building of new 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamides with potential antiproliferative activity by Abdelrahman, Mostafa H., Aboraia, Ahmed S., Youssif, Bahaa G. M., Elsadek, Bakheet E. M.

“…Novel 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamide derivatives were synthesized and evaluated for their anticancer activity. Most of the tested compounds…”
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Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents by Soliman, Aya M., El‐sagheir, Ahmed M. K., Thabet, Momen M., Abdel Hakiem, Ahmed Faried, Aboraia, Ahmed S.

“…Four piroxicam metal complexes; NiL2, PtL2, PdL2, and AgL were synthesized and characterized by different techniques with enhanced antibacterial and anticancer…”
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Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors by Mohamed, Mamdouh F.A., Shaykoon, Montaser Sh.A., Abdelrahman, Mostafa H., Elsadek, Bakheet E.M., Aboraia, Ahmed S., Abuo-Rahma, Gamal El-Din A.A.

“…[Display omitted] •Chalcone derivatives comprising hydroxamic acids or 2-aminobenzamide as zinc binding groups.•Anti-proliferative activity against human…”
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Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics by El-wahab, Hend A.A. Abd, Accietto, Mauro, Marino, Leonardo B., McLean, Kirsty J., Levy, Colin W., Abdel-Rahman, Hamdy M., El-Gendy, Mahmoud A., Munro, Andrew W., Aboraia, Ahmed S., Simons, Claire

“…[Display omitted] Three series of azole piperazine derivatives that mimic dicyclotyrosine (cYY), the natural substrate of the essential Mycobacterium…”
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Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents by Aboraia, Ahmed S., Abdel-Rahman, Hamdy M., Mahfouz, Nadia M., EL-Gendy, Mahmoud A.

“…A series of 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives was synthesized and tested for anticancer activity. A series of…”
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Small-Molecule Inhibitors of 25-Hydroxyvitamin D‑24-Hydroxylase (CYP24A1): Synthesis and Biological Evaluation by Ferla, Salvatore, Aboraia, Ahmed S, Brancale, Andrea, Pepper, Christopher J, Zhu, Jinge, Ochalek, Justin T, DeLuca, Hector F, Simons, Claire

“…The synthesis of imidazole styryl­benz­amide, tert-butyl styryl­imid­azole, and tert-butyl styryl­sulfonate derivatives is described. Evaluation of binding…”
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Design, synthesis and antiproliferative evaluation of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors by Ali, Fatma Elzahraa, Salem, Ola I.A., El-Mokhtar, Mohamed A., Aboraia, Ahmed S., Abdel-Moty, Samia G., Abdel-Aal, Abu-Baker M.

“…[Display omitted] •Sixteen new chalcones and their cyclized pyrimidine derivatives were synthesized.•The lipidated 4,6-diaryl pyrimidine-2-amine 19 exhibited…”
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Synthesis and CYP24A1 inhibitory activity of ( E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones by Aboraia, Ahmed S., Makowski, Bart, Bahja, Alba, Prosser, David, Brancale, Andrea, Jones, Glenville, Simons, Claire

“…A series of ( E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones were prepared, using an efficient synthetic scheme, and…”
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Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides by Aboraia, Ahmed S., Yee, Sook Wah, Gomaa, Mohamed Sayed, Shah, Nikhil, Robotham, Anna C., Makowski, Bart, Prosser, David, Brancale, Andrea, Jones, Glenville, Simons, Claire

“…A series of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides were prepared and evaluated for their inhibitory activity against human cytochrome P450C24A1…”
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