Search Results - "Abood, E"

CB1 Cannabinoid Receptor Signaling and Biased Signaling by Leo, Luciana M, Abood, Mary E

“…The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the…”
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Pharmacological characterization of GPR55, a putative cannabinoid receptor by Sharir, Haleli, Abood, Mary E

“…GPR55 has recently attracted much attention as another member of the cannabinoid family, potentially explaining physiological effects that are non-CB1/CB2…”
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The endocannabinoid system as a target for the treatment of neurodegenerative disease by Scotter, Emma L, Abood, Mary E, Glass, Michelle

“…The Cannabis sativa plant has been exploited for medicinal, agricultural and spiritual purposes in diverse cultures over thousands of years. Cannabis has been…”
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Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors by Brailoiu, Eugen, Chakraborty, Sumita, Brailoiu, G. Cristina, Zhao, Pingwei, Barr, Jeffrey L., Ilies, Marc A., Unterwald, Ellen M., Abood, Mary E., Taylor, Colin W.

“…Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins,…”
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Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands by Kapur, Ankur, Zhao, Pingwei, Sharir, Haleli, Bai, Yushi, Caron, Marc G., Barak, Larry S., Abood, Mary E.

“…The cannabinoid receptor 1 (CB1) and CB2 cannabinoid receptors, associated with drugs of abuse, may provide a means to treat pain, mood, and addiction…”
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Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation by Lin-Moshier, Yaping, Keebler, Michael V., Hooper, Robert, Boulware, Michael J., Liu, Xiaolong, Churamani, Dev, Abood, Mary E., Walseth, Timothy F., Brailoiu, Eugen, Patel, Sandip, Marchant, Jonathan S.

“…Significance Two-pore channels (TPCs) are a recently discovered family of endolysosomal ion channels, but their regulation is controversial. By defining the…”
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GPR55-mediated effects on brain microvascular endothelial cells and the blood–brain barrier by Leo, Luciana M., Familusi, Boluwatife, Hoang, Michelle, Smith, Raymond, Lindenau, Kristen, Sporici, Kevin T., Brailoiu, Eugen, Abood, Mary E., Brailoiu, G. Cristina

“…GPR55, an atypical cannabinoid receptor activated by lysophosphatidylinositol (LPI) has been involved in various physiological and pathological processes. We…”
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The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray by Deliu, Elena, Sperow, Margaret, Console-Bram, Linda, Carter, Rhonda L, Tilley, Douglas G, Kalamarides, Daniel J, Kirby, Lynn G, Brailoiu, G Cristina, Brailoiu, Eugen, Benamar, Khalid, Abood, Mary E

“…Emerging evidence indicates the involvement of GPR55 and its proposed endogenous ligand, lysophosphatidylinositol (LPI), in nociception, yet their role in…”
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Differential Activation of Intracellular versus Plasmalemmal CB2 Cannabinoid Receptors by Brailoiu, G. Cristina, Deliu, Elena, Marcu, Jahan, Hoffman, Nicholas E, Console-Bram, Linda, Zhao, Pingwei, Madesh, Muniswamy, Abood, Mary E, Brailoiu, Eugen

“…The therapeutic and psychoactive properties of cannabinoids have long been recognized. The type 2 receptor for cannabinoids (CB2) has emerged as an important…”
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HIV-1 infection and alcohol abuse: Neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions by Persidsky, Yuri, Ho, Wenzhe, Ramirez, Servio H, Potula, Raghava, Abood, Mary E, Unterwald, Ellen, Tuma, Ronald

“…Highlight ► This review aims to present the mechanisms of the combined effects of HIV-1 and alcohol abuse in the brain and to discuss neuroportective therapies…”
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Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor by Lingerfelt, Mary A, Zhao, Pingwei, Sharir, Haleli P, Hurst, Dow P, Reggio, Patricia H, Abood, Mary E

“…GPR55 is a newly deorphanized class A G-protein-coupled receptor that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone…”
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The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55 by Sharir, Haleli, Console-Bram, Linda, Mundy, Christina, Popoff, Steven N., Kapur, Ankur, Abood, Mary E.

“…The role of cannabinoid receptors in inflammation has been the topic of many research endeavors. Despite this effort, to date the involvement of the…”
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Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors by Brailoiu, G Cristina, Deliu, Elena, Console-Bram, Linda M, Soboloff, Jonathan, Abood, Mary E, Unterwald, Ellen M, Brailoiu, Eugen

“…Sigma-1 receptor (Sig-1R) is an intracellular chaperone protein with many ligands, located at the endoplasmic reticulum (ER). Binding of cocaine to Sig-1R has…”
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Identification of the GPR55 Antagonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands by Kotsikorou, Evangelia, Sharir, Haleli, Shore, Derek M, Hurst, Dow P, Lynch, Diane L, Madrigal, Karla E, Heynen-Genel, Susanne, Milan, Loribelle B, Chung, Thomas D. Y, Seltzman, Herbert H, Bai, Yushi, Caron, Marc G, Barak, Larry S, Croatt, Mitchell P, Abood, Mary E, Reggio, Patricia H

“…GPR55 is a class A G protein-coupled receptor (GPCR) that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development, and…”
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Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity by Zhao, Pingwei, Ignacio, Sheila, Beattie, Eric C., Abood, Mary E.

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the selective loss of spinal cord motor neurons. Excitotoxicity mediated by…”
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Identification of the GPR55 Agonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands by Kotsikorou, Evangelia, Madrigal, Karla E, Hurst, Dow P, Sharir, Haleli, Lynch, Diane L, Heynen-Genel, Susanne, Milan, Loribelle B, Chung, Thomas D. Y, Seltzman, Herbert H, Bai, Yushi, Caron, Marc G, Barak, Larry, Abood, Mary E, Reggio, Patricia H

“…Marijuana is the most widely abused illegal drug, and its spectrum of effects suggests that several receptors are responsible for the activity. Two cannabinoid…”
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Design, synthesis and biological evaluation of GPR55 agonists by Fakhouri, Lara, Cook, Christopher D., Al-Huniti, Mohammed H., Console-Bram, Linda M., Hurst, Dow P., Spano, Michael B.S., Nasrallah, Daniel J., Caron, Marc G., Barak, Larry S., Reggio, Patricia H., Abood, Mary E., Croatt, Mitchell P.

“…[Display omitted] GPR55, a G protein-coupled receptor, is an attractive target to alleviate inflammatory and neuropathic pain and treat osteoporosis and…”
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Effects of VPAC1 activation in nucleus ambiguus neurons by Liviu Gherghina, Florin, Adrian Tica, Andrei, Deliu, Elena, Abood, Mary E, Cristina Brailoiu, G, Brailoiu, Eugen

“…Highlights • We examined the effect of VPAC1, a receptor for PACAP on nucleus ambiguus, a key center controlling cardiac parasympathetic tone. • VPAC1…”
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Differential Activation of Cultured Neonatal Cardiomyocytes by Plasmalemmal Versus Intracellular G Protein-coupled Receptor 55 by Yu, Justine, Deliu, Elena, Zhang, Xue-Quian, Hoffman, Nicholas E., Carter, Rhonda L., Grisanti, Laurel A., Brailoiu, G. Cristina, Madesh, Muniswamy, Cheung, Joseph Y., Force, Thomas, Abood, Mary E., Koch, Walter J., Tilley, Douglas G., Brailoiu, Eugen

“…The L-α-lysophosphatidylinositol (LPI)-sensitive receptor GPR55 is coupled to Ca2+ signaling. Low levels of GPR55 expression in the heart have been reported…”
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An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region by McAllister, Sean D, Rizvi, Gulrukh, Anavi-Goffer, Sharon, Hurst, Dow P, Barnett-Norris, Judy, Lynch, Diane L, Reggio, Patricia H, Abood, Mary E

“…The cannabinoid CB1 receptor transmembrane helix (TMH) 3−4−5−6 region includes an aromatic microdomain comprised of residues F3.25, F3.36, W4.64, Y5.39, W5.43,…”
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