Combined oral contraceptive and nitric oxide synthesis inhibition synergistically causes cardiac hypertrophy and exacerbates insulin resistance in female rats

Highlights • COC treatment or NO deficiency induces high blood pressure and cardiometabolic disturbances. • COC treatment or NO deficiency does not result in increased cardiac mass. • COC treatment and NO deficiency synergistically causes cardiac hypertrophy. • COC treatment during NO deficiency exa...

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Bibliographic Details
Published in:	Environmental toxicology and pharmacology Vol. 52; pp. 54 - 61
Main Authors:	Olatunji, Lawrence A, Olaniyi, Kehinde S, Usman, Taofeek O, Abolarinwa, Bilikis A, Achile, Caleb J, Kim, In-kyeom
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2017 Elsevier Science Ltd
Subjects:	Animals Arginine Biomarkers Birth control Blood pressure Blood Pressure - drug effects C-reactive protein C-Reactive Protein - analysis Cardiac hypertrophy Cardiomegaly - blood Cardiomegaly - chemically induced Contraceptives, Oral, Combined - pharmacology Deregulation Dyslipidemia Emergency Estradiol - blood Ethinyl Estradiol - pharmacology Ethinylestradiol Female Fibrosis Glucose Heart Heart diseases Hypertension Hypertrophy Inflammation Inhibition Insulin Insulin Resistance Levonorgestrel - pharmacology NG-Nitroarginine methyl ester NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - deficiency Oral contraceptive Plasminogen Activator Inhibitor 1 - blood Plasminogen activator inhibitors Plethysmography Profibrotic biomarker Rats Rats, Wistar Synthesis Uric acid Uric Acid - blood Cardiac hypertrophy Inflammation Oral contraceptive Profibrotic biomarker Nitric oxide
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Summary:	Highlights • COC treatment or NO deficiency induces high blood pressure and cardiometabolic disturbances. • COC treatment or NO deficiency does not result in increased cardiac mass. • COC treatment and NO deficiency synergistically causes cardiac hypertrophy. • COC treatment during NO deficiency exacerbates cardiometabolic disturbances.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2017.03.012