Search Results - "Aboelez, Moustafa O."

DNA interaction, antimicrobial, anticancer activities and molecular docking study of some new VO(II), Cr(III), Mn(II) and Ni(II) mononuclear chelates encompassing quaridentate imine ligand by Abdel-Rahman, Laila H., Abu-Dief, Ahmed M., Aboelez, Moustafa O., Hassan Abdel-Mawgoud, Azza A.

“…The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol…”
Get full text

Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFRWT and EGFRT790M by O. Aboelez, Moustafa, Belal, Amany, Xiang, Guangya, Ma, Xiang

“…A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells…”
Get full text

Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3- b ] Pyrrole Derivatives by Kamel, Moumen S, Belal, Amany, Aboelez, Moustafa O, Shokr, E Kh, Abdel-Ghany, H, Mansour, Hany S, Shawky, Ahmed M, El-Remaily, Mahmoud Abd El Aleem Ali Ali

“…Novel pyrrolo [2,3- ] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the…”
Get full text

Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management by Belal, Amany, Elanany, Mohamed A, Santali, Eman Y, Al-Karmalawy, Ahmed A, Aboelez, Moustafa O, Amin, Ali H, Abdellattif, Magda H, Mehany, Ahmed B M, Elkady, Hazem

“…Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still…”
Get full text

Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology by Elsayed, Mahmoud M A, Aboelez, Moustafa O, Elsadek, Bakheet E M, Sarhan, Hatem A, Khaled, Khaled Ali, Belal, Amany, Khames, Ahmed, Hassan, Yasser A, Abdel-Rheem, Amany A, Elkaeed, Eslam B, Raafat, Mohamed, Elsadek, Mahmoud Elkot Mostafa

“…Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort…”
Get full text

Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study by Elsayed, Mahmoud M. A, Aboelez, Moustafa O, Mohamed, Mohamed S, Mahmoud, Reda A, El-Shenawy, Ahmed A, Mahmoud, Essam A, Al-Karmalawy, Ahmed A, Santali, Eman Y, Alshehri, Sameer, Elsadek, Mahmoud Elkot Mostafa, El Hamd, Mohamed A, Ramadan, Abd El hakim

“…Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and…”
Get full text

Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFR WT and EGFR T790M by O Aboelez, Moustafa, Belal, Amany, Xiang, Guangya, Ma, Xiang

“…A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells…”
Get full text

Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of Newborn: A Pilot Randomized Controlled Trial by Abdelkreem, Elsayed, Mahmoud, Shaimaa M., Aboelez, Moustafa O., Abd El Aal, Mohamed

“…Objectives To investigate the effectiveness of nebulized magnesium sulfate in treating persistent pulmonary hypertension of newborn (PPHN). Methods…”
Get full text

Inflammatory setting, therapeutic strategies targeting some pro-inflammatory cytokines and pathways in mitigating ischemia/reperfusion-induced hepatic injury: a comprehensive review by Aboelez, Moustafa O., Ezelarab, Hend A. A., Alotaibi, Ghallab, Abouzed, Deiaa E. Elsayed

“…Ischemia/reperfusion injury (IRI) is a key determining agent in the pathophysiology of clinical organ dysfunction. It is characterized by an aseptic local…”
Get full text

Eco-friendly and regiospecific intramolecular cyclization reactions of cyano and carbonyl groups in N,N-disubstituted cyanamide by Moustafa, Amr H., Ahmed, Walaa W., Awad, Mohamed F., Aboelez, Moustafa O., Khodairy, Ahmed, Amer, Amer A.

“…Eco-friendly, low-cost and high-yielding synthetic route toward imidazoles and oxazoles has been developed…”
Get full text

Multimodal modulation of hepatic ischemia/reperfusion-induced injury by phytochemical agents: A mechanistic evaluation of hepatoprotective potential and safety profiles by Elsayed Abouzed, Deiaa E., Ezelarab, Hend A.A., Selim, Heba Mohammed Refat M., Elsayed, Mahmoud M.A., El Hamd, Mohamed A., Aboelez, Moustafa O.

“…•Ischemia reperfusion, linked to early/late graft rejection after liver transplant, liver failure after many liver surgeries.•Phytochemical agents exhibited…”
Get full text

Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and EGFRT790M by Aboelez, Moustafa O., Kamel, Moumen S., Belal, Amany, El Badry Abdel-Aziz, Ahmed, Abourehab, Mohammed A. S., Abdel-Ghany, H., A. El Hamd, Mohamed, El-Remaily, Mahmoud Abd El Aleem Ali

“…Epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase that is usually overexpressed in many types of cancers. In the present…”
Get full text

Design and evaluation of sulfadiazine derivatives as potent dual inhibitors of EGFRWT and EGFRT790M: integrating biological, molecular docking, and ADMET analysis by Abd El-Lateef, Hany M, Ezelarab, Hend A A, Ali, Ali M, Alsaggaf, Azhaar T, Mahdi, Wael A, Alshehri, Sultan, El Hamd, Mohamed A, Aboelez, Moustafa O

“…A series of derivatives (5–14) were synthesized through the diazotization of sulfadiazine with active methylene compounds. The chemical structures of these…”
Get full text

Design and evaluation of sulfadiazine derivatives as potent dual inhibitors of EGFR WT and EGFR T790M : integrating biological, molecular docking, and ADMET analysis by Abd El-Lateef, Hany M, Ezelarab, Hend A A, Ali, Ali M, Alsaggaf, Azhaar T, Mahdi, Wael A, Alshehri, Sultan, El Hamd, Mohamed A, Aboelez, Moustafa O

“…A series of derivatives (5-14) were synthesized through the diazotization of sulfadiazine with active methylene compounds. The chemical structures of these…”
Get full text

One‐Pot Multicomponent Synthesis of Novel 2‐Tosyloxyphenylpyrans under Green and Conventional Condition with Anti‐inflammatory Activity by Khodairy, Ahmed, Ali, Ali M., Aboelez, Moustafa O., El‐Wassimy, M. T.

“…A mild, efficient, and environmentally green protocol for the synthesis of 2‐tosyloxyphenylpyran derivatives 3, 4, 5, 6, 7, 8, 9, 10, 11 via reaction of…”
Get full text

Design, spectroscopic characterizations, and biological investigation of oxospiro[chromine-4,3-indolene]-based compounds as promising antiproliferative EGFR inhibitors and antimicrobial agents by Alzahrani, Abdullah Yahya Abdullah, Aboelez, Moustafa O, Kamel, Moumen S, Selim, Heba Mohammed Refat M, Alsaggaf, Azhaar T, Hamd, Mohammed A El, El-Remaily, Mahmoud Abd El Aleem Ali Ali

“…Utilizing microwave heating and an aqueous saturated solution of K CO as a catalyst, a rapidone-pot synthesis of oxospiro[chromene-4.3-indoline] derivatives…”
Get full text

Guanidine dicycloamine-based analogs: green chemistry synthesis, biological investigation, and molecular docking studies as promising antibacterial and antiglycation leads by El-Remaily, Mahmoud Abd El Aleem A A, Aboelez, Moustafa O, Ezelarab, Hend A A, Selim, Heba Mohammed Refat M, Taha, Enas A, Mohamed, Shaaban K, Soliman, Ahmed M, Abdallah, Mohamed S, Fawy, Mariam A, Hassany, Mohamed A, Ahmed, Nessar, Alsaggaf, Azhaar T, El Hamd, Mohamed A, Kamel, Moumen S

“…Dicyandiamide (DCD) reacted with amino acids 1a-f to produce biguanides 2 and 4 and guanidine pyrazolones 3, 5, 6, 7, and 8, according to the reaction. DCD…”
Get full text

New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity by Shoman, Mai E., Aboelez, Moustafa O., Shaykhon, Montaser SH. A., Ahmed, Sanaa A., Abuo-Rahma, Gamal El-Din A., Elhady, Omar M.

“…Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their…”
Get full text

Synthesis, in vitro Antibacterial and in vivo Anti-Inflammatory Activity of Some New Pyridines by Ghattas, Abd-El-Badih A. G., Khodairy, Ahmed, Moustafa, Hassan M., Hussein, Bahgat R. M., Farghaly, Marwa M., Aboelez, Moustafa O.

“…Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine ( I ) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and…”
Get full text

Thieno[2,3‑b]thiophene Derivatives as Potential EGFRWT and EGFRT790M Inhibitors with Antioxidant Activities: Microwave-Assisted Synthesis and Quantitative In Vitro and In Silico Studies by Ahmed, Sanaa A., Kamel, Moumen S., Aboelez, Moustafa O., Ma, Xiang, Al-Karmalawy, Ahmed A., Mousa, Sayed A. S., Shokr, Elders Kh, Abdel-Ghany, H., Belal, Amany, El Hamd, Mohamed A., Al Shehri, Zafer S., El Aleem Ali Ali El-Remaily, Mahmoud Abd

“…Microwave-assisted synthesis and spectral analysis of certain novel derivatives of 3,4-diaminothieno­[2,3-b]­thiophene-2,5-dicarbonitrile 1–7 were carried out…”
Get full text