Search Results - "Ablordeppey, Seth"

The Mechanistic Targets of Antifungal Agents: An Overview by Mazu, Tryphon K, Bricker, Barbara A, Flores-Rozas, Hernan, Ablordeppey, Seth Y

“…Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS patients and other immunocompromised individuals are at risk for OIs,…”
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An Evaluation of the Anticancer Properties of SYA014, a Homopiperazine-Oxime Analog of Haloperidol in Triple Negative Breast Cancer Cells by Asong, Gladys M, Voshavar, Chandrashekhar, Amissah, Felix, Bricker, Barbara, Lamango, Nazarius S, Ablordeppey, Seth Y

“…Triple negative breast cancer (TNBC) is a type of breast cancer associated with early metastasis, poor prognosis, high relapse rates, and mortality…”
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New analogs of SYA013 as sigma-2 ligands with anticancer activity by Asong, Gladys, Zhu, Xue Y., Bricker, Barbara, Andey, Terrick, Amissah, Felix, Lamango, Nazarius, Ablordeppey, Seth Y.

“…[Display omitted] Our previous study has revealed 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one·2HCl (SYA013) 1 as a sigma ligand with…”
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SYA 013 analogs as moderately selective sigma-2 (σ2) ligands: Structure-affinity relationship studies by Al-Ghanim, Lamya, Zhu, Xue Y., Asong, Gladys, Ablordeppey, Seth Y.

“…[Display omitted] Several lines of evidence suggest that selective sigma-2 (σ2) ligands might be useful for the treatment of solid tumors. However, very few…”
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Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: Assessment of a new, commercially available, semi-automated instrument by Bricker, Barbara, Sampson, Dinithia, Ablordeppey, Seth Y.

“…Haloperidol induced catalepsy was determined using the classic bar test and a new MED Associates Catalepsy Test Chamber instrument. The dose that produced an…”
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A study of the structure-affinity relationship in SYA16263; is a D2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? by Onyameh, Edem K., Bricker, Barbara A., Eyunni, Suresh V.K., Voshavar, Chandrashekhar, Gonela, Uma M., Ofori, Edward, Jenkins, Andrea, Ablordeppey, Seth Y.

“…[Display omitted] Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor…”
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A study of the structure-affinity relationship in SYA16263; is a D 2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? by Onyameh, Edem K, Bricker, Barbara A, Eyunni, Suresh V K, Voshavar, Chandrashekhar, Gonela, Uma M, Ofori, Edward, Jenkins, Andrea, Ablordeppey, Seth Y

“…Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor subtype to the…”
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Enantioseparation of 5‐chloro‐2‐{2‐[3,4‐dihydroisoquinoline‐2(1H)‐yl]ethyl}‐2‐methyl‐2,3‐dihydro‐1H‐inden‐1‐one (SYA 40247), a high‐affinity 5‐HT7 receptor ligand, by HPLC–PDA using amylose tris‐(3, 5‐ dimethylphenylcarbamate) as a chiral stationary phase by Onyameh, Edem K., Bricker, Barbara A., Ofori, Edward, Ablordeppey, Seth Y.

“…In previous structure–activity relationship studies to identify new and selective 5‐HT7 receptor (5‐HT7R) ligands, we identified the chiral compound,…”
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New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263 by Ofori, Edward, Onyameh, Edem K., Gonela, Uma M., Voshavar, Chandrashekhar, Bricker, Barbara, Swanson, Tracy L., Eshleman, Amy J., Schmachtenberg, Jennifer L., Bloom, Shelley H., Janowsky, Aaron J., Ablordeppey, Seth Y.

“…We have previously reported that dual 5-HT1A and 5-HT7 receptor ligands might find utility as treatment options for various CNS related conditions including…”
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Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors by Ofori, Edward, Zhu, Xue Y, Etukala, Jagan R, Bricker, Barbara A, Ablordeppey, Seth Y

“…Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the…”
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Indolo[3,2-b]quinolines: synthesis, biological evaluation and structure activity-relationships by Kumar, Eyunni V K Suresh, Etukala, Jagan R, Ablordeppey, Seth Y

“…The tetracyclic indolo[3,2-b]quinoline ring system constitutes an important structural moiety in natural products exhibiting numerous biological activities. In…”
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Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands by Ofori, Edward, Zhu, Xue Y., Etukala, Jagan R., Peprah, Kwakye, Jordan, Kamanski R., Adkins, Adia A., Bricker, Barbara A., Kang, Hye J., Huang, Xi-Ping, Roth, Bryan L., Ablordeppey, Seth Y.

“…[Display omitted] 5-HT1A and 5-HT7 receptors have been at the center of discussions recently due in part to their major role in the etiology of major central…”
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Design and discovery of a high affinity, selective and β-arrestin biased 5-HT7 receptor agonist by Onyameh, Edem K., Ofori, Edward, Bricker, Barbara A., Gonela, Uma M., Eyunni, Suresh V. K., Kang, Hye J., Voshavar, Chandrashekar, Ablordeppey, Seth Y.

“…Compound 1c , 5-chloro-2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-2,3-dihydro-1H-inden-1-one was previously reported from our laboratory showing high…”
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A Mechanistic Investigation on the Anticancer Properties of SYA013, a Homopiperazine Analogue of Haloperidol with Activity against Triple Negative Breast Cancer Cells by Asong, Gladys M, Amissah, Felix, Voshavar, Chandrashekhar, Nkembo, Augustine T, Ntantie, Elizabeth, Lamango, Nazarius S, Ablordeppey, Seth Y

“…Triple-negative breast cancer (TNBC) is one of the most malignant cancers associated with early metastasis, poor clinical prognosis, and high recurrence rate…”
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CoMFA studies and in vitro evaluation of some 3-substituted benzylthio quinolinium salts as anticryptococcal agents by Bolden, Sidney, Boateng, Comfort A., Zhu, Xue Y., Etukala, Jagan R., Eyunni, Suresh K., Jacob, Melissa R., Khan, Shabana I., Ablordeppey, Seth Y.

“…3-Substituted quinolinium salts. The 3-dimensional quantitative structure–activity relationship (3D-QSAR) molecular modeling technique or comparative molecular…”
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Identification of a new selective dopamine D4 receptor ligand by Sampson, Dinithia, Zhu, Xue Y., Eyunni, Suresh V.K., Etukala, Jagan R., Ofori, Edward, Bricker, Barbara, Lamango, Nazarius S., Setola, Vincent, Roth, Bryan L., Ablordeppey, Seth Y.

“…The dopamine D4 receptor has been shown to play key roles in certain CNS pathologies including addiction to cigarette smoking. Thus, selective D4 ligands may…”
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Enantiomeric Separation, Absolute Configuration by X‑ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5‑HT1A and 5‑HT7A Receptors by Bricker, Barbara A., Voshavar, Chandrashekhar, Onyameh, Edem K., Gonela, Uma M., Lin, Xinsong, Swanson, Tracy L., Kozell, Laura B., Schmachtenberg, Jennifer L., Bloom, Shelley H., Janowsky, Aaron J., Ablordeppey, Seth Y.

“…We have previously identified 5-chloro-2-methyl-2-(3-(4-(pyridin-2-yl)­piperazin-1-yl)­propyl)-2,3-dihydro-1H-inden-1-one (SYA0340) as a dual 5-HT1A and 5-HT7…”
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Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT 1A and 5-HT 7A Receptors by Bricker, Barbara A, Voshavar, Chandrashekhar, Onyameh, Edem K, Gonela, Uma M, Lin, Xinsong, Swanson, Tracy L, Kozell, Laura B, Schmachtenberg, Jennifer L, Bloom, Shelley H, Janowsky, Aaron J, Ablordeppey, Seth Y

“…We have previously identified 5-chloro-2-methyl-2-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)-2,3-dihydro-1 -inden-1-one (SYA0340) as a dual 5-HT and 5-HT…”
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Further evaluation of the tropane analogs of haloperidol by Sampson, Dinithia, Bricker, Barbara, Zhu, Xue Y., Peprah, Kwakye, Lamango, Nazarius S., Setola, Vincent, Roth, Bryan L., Ablordeppey, Seth Y.

“…Previous work from our labs has indicated that a tropane analog of haloperidol with potent D2 binding but designed to avoid the formation of MPP+-like…”
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Polyisoprenylated methylated protein methyl esterase: A putative biomarker and therapeutic target for pancreatic cancer by Aguilar, Byron J., Nkembo, Augustine T., Duverna, Randolph, Poku, Rosemary A., Amissah, Felix, Ablordeppey, Seth Y., Lamango, Nazarius S.

“…Pancreatic cancer is the most deadly neoplasm with a 5-year survival rate of less than 6%. Over 90% of cases harbor K-Ras mutations, which are the most…”
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