Search Results - "Abkevich, Victor"

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer by Telli, Melinda L, Timms, Kirsten M, Reid, Julia, Hennessy, Bryan, Mills, Gordon B, Jensen, Kristin C, Szallasi, Zoltan, Barry, William T, Winer, Eric P, Tung, Nadine M, Isakoff, Steven J, Ryan, Paula D, Greene-Colozzi, April, Gutin, Alexander, Sangale, Zaina, Iliev, Diana, Neff, Chris, Abkevich, Victor, Jones, Joshua T, Lanchbury, Jerry S, Hartman, Anne-Renee, Garber, Judy E, Ford, James M, Silver, Daniel P, Richardson, Andrea L

“…BRCA1/2-mutated and some sporadic triple-negative breast cancers (TNBC) have DNA repair defects and are sensitive to DNA-damaging therapeutics. Recently, three…”
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Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer by HENNESSY, Bryan T. J, TIMMS, Kirsten M, YANG LI, JIE LI, GONZALEZ-ANGULO, Ana Maria, MCCUNE, Karen Smith, MARKMAN, Maurie, BROADDUS, Russell R, LANCHBURY, Jerry S, LU, Karen H, MILLS, Gordon B, CAREY, Mark S, GUTIN, Alexander, MEYER, Larissa A, FLAKE, Darl D, ABKEVICH, Victor, POTTER, Jennifer, PRUSS, Dmitry, GLENN, Pat

“…The prevalence of BRCA(1/2) mutations in germline DNA from unselected ovarian cancer patients is 11% to 15.3%. It is important to determine the frequency of…”
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Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene by Capon, Francesca, Bijlmakers, Marie-José, Wolf, Natalie, Quaranta, Maria, Huffmeier, Ulrike, Allen, Michael, Timms, Kirsten, Abkevich, Victor, Gutin, Alexander, Smith, Rhodri, Warren, Richard B., Young, Helen S., Worthington, Jane, Burden, A. David, Griffiths, Christopher E.M., Hayday, Adrian, Nestle, Frank O., Reis, Andre, Lanchbury, Jerry, Barker, Jonathan N., Trembath, Richard C.

“…Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage studies have clearly identified a primary disease…”
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P063: A second-generation polygenic risk score (PRS) based on genetic ancestry improves breast cancer (BC) risk prediction for all ancestries by Simmons, Timothy, Hughes, Elisha, Pruss, Dmitry, Kucera, Matthew, Roa, Benjamin, Judkins, Thaddeus, Slavin, Thomas, Abkevich, Victor, Hoff, Ryan, Jammulapati, Srikanth, Wagner, Susanne, Muzzey, Dale, Lanchbury, Jerry, Gutin, Alexander

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Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis by Valdes, Ana M., Loughlin, John, Timms, Kirsten M., van Meurs, Joyce J.B., Southam, Lorraine, Wilson, Scott G., Doherty, Sally, Lories, Rik J., Luyten, Frank P., Gutin, Alexander, Abkevich, Victor, Ge, Dongliang, Hofman, Albert, Uitterlinden, André G., Hart, Deborah J., Zhang, Feng, Zhai, Guangju, Egli, Rainer J., Doherty, Michael, Lanchbury, Jerry, Spector, Tim D.

“…Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic…”
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Predisposition Locus for Major Depression at Chromosome 12q22-12q23.2 by Abkevich, Victor, Camp, Nicola J., Hensel, Charles H., Neff, Chris D., Russell, Deanna L., Hughes, Dana C., Plenk, Agnes M., Lowry, Michael R., Richards, R. Lynn, Carter, Catherine, Frech, Georges C., Stone, Steven, Rowe, Kerry, Chau, Chi Ai, Cortado, Kathleen, Hunt, Angelene, Luce, Karanina, O’Neil, Gayanne, Poarch, Jeff, Potter, Jennifer, Poulsen, Gregg H., Saxton, Heidi, Bernat-Sestak, Michelle, Thompson, Victor, Gutin, Alexander, Skolnick, Mark H., Shattuck, Donna, Cannon-Albright, Lisa

“…Major depression disorder is a common psychiatric disease with a major economic impact on society. In many cases, no effective treatment is available. The…”
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How Evolution Makes Proteins Fold Quickly by Mirny, Leonid A., Abkevich, Victor I., Shakhnovich, Eugene I.

“…Sequences of fast-folding model proteins (48 residues long on a cubic lattice) were generated by an evolution-like selection toward fast folding. We find that…”
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Mapping of homozygous deletions in verified esophageal adenocarcinoma cell lines and xenografts by Boonstra, Jurjen J., van Marion, Ronald, Douben, Hannie J. C. W., Lanchbury, Jerry S., Timms, Kirsten M., Abkevich, Victor, Tilanus, Hugo W., de Klein, Annelies, Dinjens, Winand N. M.

“…Human esophageal adenocarcinoma (EAC) cell lines and xenografts are powerful tools in the search for genetic alterations because these models are composed of…”
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A Major Predisposition Locus for Severe Obesity, at 4p15-p14 by Stone, Steven, Abkevich, Victor, Hunt, Steven C., Gutin, Alexander, Russell, Deanna L., Neff, Chris D., Riley, Robyn, Frech, Georges C., Hensel, Charles H., Jammulapati, Srikanth, Potter, Jennifer, Sexton, David, Tran, Thanh, Gibbs, Drew, Iliev, Diana, Gress, Richard, Bloomquist, Brian, Amatruda, John, Peter Rae, M.M., Ted Adams, D., Mark Skolnick, H., Shattuck, Donna

“…Although the predisposition to morbid obesity is heritable, the identities of the disease-causing genes are largely unknown. Therefore, we have conducted a…”
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Association of BRCA1/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes by Timms, Kirsten M, Abkevich, Victor, Hughes, Elisha, Neff, Chris, Reid, Julia, Morris, Brian, Kalva, Saritha, Potter, Jennifer, Tran, Thanh V, Chen, Jian, Iliev, Diana, Sangale, Zaina, Tikishvili, Eliso, Perry, Michael, Zharkikh, Andrey, Gutin, Alexander, Lanchbury, Jerry S

“…Homologous recombination (HR) DNA repair is of clinical relevance in breast cancer. Three DNA-based homologous recombination deficiency (HRD) scores (HRD-loss…”
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Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105 by Telli, Melinda L, Jensen, Kristin C, Vinayak, Shaveta, Kurian, Allison W, Lipson, Jafi A, Flaherty, Patrick J, Timms, Kirsten, Abkevich, Victor, Schackmann, Elizabeth A, Wapnir, Irene L, Carlson, Robert W, Chang, Pei-Jen, Sparano, Joseph A, Head, Bobbie, Goldstein, Lori J, Haley, Barbara, Dakhil, Shaker R, Reid, Julia E, Hartman, Anne-Renee, Manola, Judith, Ford, James M

“…This study was designed to assess efficacy, safety, and predictors of response to iniparib in combination with gemcitabine and carboplatin in early-stage…”
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Homologous recombination deficiency (HRD) status predicts response to standard neoadjuvant chemotherapy in patients with triple-negative or BRCA1/2 mutation-associated breast cancer by Telli, Melinda L., Hellyer, Jessica, Audeh, William, Jensen, Kristin C., Bose, Shikha, Timms, Kirsten M., Gutin, Alexander, Abkevich, Victor, Peterson, Rebecca N., Neff, Chris, Hughes, Elisha, Sangale, Zaina, Jones, Joshua, Hartman, Anne-Renee, Chang, Pei-Jen, Vinayak, Shaveta, Wenstrup, Richard, Ford, James M.

“…Purpose Defects in the homologous recombination (HR) DNA repair pathway sensitize tumors to therapeutics that target this pathway. A significant proportion of…”
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Phase II neoadjuvant clinical trial of carboplatin and eribulin in women with triple negative early-stage breast cancer (NCT01372579) by Kaklamani, Virginia G., Jeruss, Jacqueline S., Hughes, Elisha, Siziopikou, Kalliopi, Timms, Kirsten M., Gutin, Alexander, Abkevich, Victor, Sangale, Zaina, Solimeno, Cara, Brown, Krystal L., Jones, Joshua, Hartman, Anne-Renee, Meservey, Caitlin, Jovanovic, Borko, Helenowski, Irene, Khan, Seema A., Bethke, Kevin, Hansen, Nora, Uthe, Regina, Giordano, Sara, Rosen, Steven, Hoskins, Kent, Von Roenn, Jamie, Jain, Sarika, Parini, Vamsi, Gradishar, William

“…The purpose of this study is to evaluate the efficacy and safety of neoadjuvant treatment with carboplatin and eribulin in patients with early-stage triple…”
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Abstract PS10-07: A second-generation polygenic risk score (PRS) based on genetic ancestry improves breast cancer (BC) risk prediction for all ancestries by Simmons, Timothy, Hughes, Elisha, Pruss, Dmitry, Kucera, Matthew, Roa, Benjamin, Judkins, Thaddeus, Slavin, Thomas, Abkevich, Victor, Hoff, Ryan, Jammulapati, Srikanth, Wagner, Susanne, Muzzey, Dale, Lanchbury, Jerry, Gutin, Alexander

“…Abstract Background: Common genetic variants, mainly single-nucleotide polymorphisms (SNPs) explain substantial genetic susceptibility to BC. PRS have been…”
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Analysis of tumor samples from SOLO2: Concordance of BRCA mutation ( BRCA m) detection in tumor vs. blood and frequency of BRCA -specific loss of heterozygosity (LOH) and loss of function somatic mutations by Hodgson, Darren R., Dearden, Simon Patrick, Brown, Jessica S, Milenkova, Tsveta, Lanchbury, Jerry S, Perry, Michael, Gutin, Alexander, Abkevich, Victor, Timms, Kirsten, Harrington, Elizabeth, Barrett, J Carl, Lai, Zhongwu, Dougherty, Brian Andrew, Pujade-Lauraine, Eric

“…Abstract only…”
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Locus-specific loss of heterozygosity (LOH) in BRCA1/2 mutated (mBRCA) ovarian tumors from the SOLO2 (NCT01874353) and Study 19 (NCT00753545) clinical trials by Timms, Kirsten, Brown, Jessica S, Hodgson, Darren R., Barrett, J Carl, Milenkova, Tsveta, Ledermann, Jonathan A., Gourley, Charlie, Pujade-Lauraine, Eric, Perry, Michael, Gutin, Alexander, Abkevich, Victor, Lanchbury, Jerry S

“…Abstract only…”
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Improved design of stable and fast-folding model proteins by Abkevich, Victor I, Gutin, Alexander M, Shakhnovich, Eugene I

“…A number of approaches to design stable and fast-folding sequences for model polypeptide chains have been based on the premise that optimization of the…”
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Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition by Hughes, Elisha, Wagner, Susanne, Pruss, Dmitry, Bernhisel, Ryan, Probst, Braden, Abkevich, Victor, Simmons, Timothy, Hullinger, Brooke, Judkins, Thaddeus, Rosenthal, Eric, Roa, Benjamin, Domchek, Susan M, Eng, Charis, Garber, Judy, Gary, Monique, Klemp, Jennifer, Mukherjee, Semanti, Offit, Kenneth, Olopade, Olufunmilayo I, Vijai, Joseph, Weitzel, Jeffrey N, Whitworth, Pat, Yehia, Lamis, Gordon, Ora, Pederson, Holly, Kurian, Allison, Slavin, Thomas P, Gutin, Alexander, Lanchbury, Jerry S

“…Polygenic risk scores (PRSs) for breast cancer (BC) risk stratification have been developed primarily in women of European ancestry. Their application to women…”
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IL23R R381Q and ATG16L1 T300A Are Strongly Associated With Crohn's Disease in a Study of New Zealand Caucasians With Inflammatory Bowel Disease by ROBERTS, Rebecca L, GEARRY, Richard B, BARCLAY, Murray L, KENNEDY, Martin A, HOLLIS-MOFFATT, Jade E, MILLER, Allison L, REID, Julia, ABKEVICH, Victor, TIMMS, Kirsten M, GUTIN, Alexander, LANCHBURY, Jerry S, MERRIMAN, Tony R

“…Recently, separate genome-wide association analyses have identified nonsynonymous SNPs in IL23R and ATG16L1 (rs11209026; c1142G>A, R381Q, and rs2241880;…”
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Abstract C53: Homologous recombination deficiency (HRD) of high grade serous ovarian tumors from the NOVA Phase III clinical study by Wilcoxen, Keith, Neff, Christopher, Abkevich, Victor, Jones, Joshua Timothy, Kolquist, Kathryn, Mirza, Michael, Lanchbury, Jerry, Mikule, Keith, Agarwal, Shefali, Hartman, Anne-Renee, Gutin, Alexander, Timms, Kirsten

“…Abstract Background: Genome-wide analysis was conducted on tumors obtained from patients enrolled in the NOVA study, a Phase 3 clinical trial evaluating the…”
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