Search Results - "Abitbol, Julia M"
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Lineage-tracing and translatomic analysis of damage-inducible mitotic cochlear progenitors identifies candidate genes regulating regeneration
Published in PLoS biology (01-11-2021)“…Cochlear supporting cells (SCs) are glia-like cells critical for hearing function. In the neonatal cochlea, the greater epithelial ridge (GER) is a mitotically…”
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Differential effects of pannexins on noise-induced hearing loss
Published in Biochemical journal (15-12-2016)“…Hearing loss, including noise-induced hearing loss, is highly prevalent and severely hinders an individual's quality of life, yet many of the mechanisms that…”
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Hair Cell Regeneration: From Animals to Humans
Published in Clinical and experimental otorhinolaryngology (01-02-2024)“…Cochlear hair cells are critical in converting sound into electrical signals that are relayed via the spiral ganglion neurons to the central auditory pathway…”
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Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea
Published in Molecular therapy. Methods & clinical development (14-09-2023)“…Adeno-associated virus (AAV)-mediated gene transfer has shown promise in rescuing mouse models of genetic hearing loss, but how viral capsid and promoter…”
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GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells
Published in Frontiers in cell and developmental biology (02-04-2020)“…gene (that encodes Cx26) mutations are causal of hearing loss highlighting the importance of Cx26-based channel signaling amongst the supporting cells in the…”
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The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss
Published in Journal of cell science (16-01-2019)“…Mutations in the genes that encode the gap junction proteins connexin 26 (Cx26, encoded by ) and Cx30 ( ) are the leading cause of hereditary hearing loss…”
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Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss
Published in Journal of cell science (01-05-2018)“…Given the importance of connexin43 (Cx43, encoded by ) function in the central nervous system and sensory organ processing, we proposed that it would also be…”
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