Search Results - "Abilez, Oscar J."

Chemically defined generation of human cardiomyocytes by Burridge, Paul W, Matsa, Elena, Shukla, Praveen, Lin, Ziliang C, Churko, Jared M, Ebert, Antje D, Lan, Feng, Diecke, Sebastian, Huber, Bruno, Mordwinkin, Nicholas M, Plews, Jordan R, Abilez, Oscar J, Cui, Bianxiao, Gold, Joseph D, Wu, Joseph C

“…A simple, robust, chemically defined method for generating cardiomyocytes from human pluripotent stem cells is described. It should enable the identification…”
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Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells by Lan, Feng, Lee, Andrew S., Liang, Ping, Sanchez-Freire, Veronica, Nguyen, Patricia K., Wang, Li, Han, Leng, Yen, Michelle, Wang, Yongming, Sun, Ning, Abilez, Oscar J., Hu, Shijun, Ebert, Antje D., Navarrete, Enrique G., Simmons, Chelsey S., Wheeler, Matthew, Pruitt, Beth, Lewis, Richard, Yamaguchi, Yoshinori, Ashley, Euan A., Bers, Donald M., Robbins, Robert C., Longaker, Michael T., Wu, Joseph C.

“…Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked to arrhythmia and sudden cardiac death. While the causes of HCM…”
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Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model by Riegler, Johannes, Tiburcy, Malte, Ebert, Antje, Tzatzalos, Evangeline, Raaz, Uwe, Abilez, Oscar J, Shen, Qi, Kooreman, Nigel G, Neofytou, Evgenios, Chen, Vincent C, Wang, Mouer, Meyer, Tim, Tsao, Philip S, Connolly, Andrew J, Couture, Larry A, Gold, Joseph D, Zimmermann, Wolfram H, Wu, Joseph C

“…RATIONALE:Tissue engineering approaches may improve survival and functional benefits from human embryonic stem cell–derived cardiomyocyte transplantation,…”
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Stretching skeletal muscle: chronic muscle lengthening through sarcomerogenesis by Zöllner, Alexander M, Abilez, Oscar J, Böl, Markus, Kuhl, Ellen

“…Skeletal muscle responds to passive overstretch through sarcomerogenesis, the creation and serial deposition of new sarcomere units. Sarcomerogenesis is…”
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Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling by Abilez, Oscar J., Tzatzalos, Evangeline, Yang, Huaxiao, Zhao, Ming‐Tao, Jung, Gwanghyun, Zöllner, Alexander M., Tiburcy, Malte, Riegler, Johannes, Matsa, Elena, Shukla, Praveen, Zhuge, Yan, Chour, Tony, Chen, Vincent C., Burridge, Paul W., Karakikes, Ioannis, Kuhl, Ellen, Bernstein, Daniel, Couture, Larry A., Gold, Joseph D., Zimmermann, Wolfram H., Wu, Joseph C.

“…The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium,…”
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Multiscale Computational Models for Optogenetic Control of Cardiac Function by Abilez, Oscar J., Wong, Jonathan, Prakash, Rohit, Deisseroth, Karl, Zarins, Christopher K., Kuhl, Ellen

“…The ability to stimulate mammalian cells with light has significantly changed our understanding of electrically excitable tissues in health and disease, paving…”
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Effect of Human Donor Cell Source on Differentiation and Function of Cardiac Induced Pluripotent Stem Cells by Sanchez-Freire, Veronica, PhD, Lee, Andrew S., PhD, Hu, Shijun, PhD, Abilez, Oscar J., MD, Liang, Ping, PhD, Lan, Feng, PhD, Huber, Bruno C., MD, Ong, Sang-Ging, PhD, Hong, Wan Xing, MS, Huang, Mei, PhD, Wu, Joseph C., MD, PhD

“…Abstract Background Human-induced pluripotent stem cells (iPSCs) are a potentially unlimited source for generation of cardiomyocytes (iPSC-CMs). However,…”
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Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy by Sun, Ning, Yazawa, Masayuki, Liu, Jianwei, Han, Leng, Sanchez-Freire, Veronica, Abilez, Oscar J, Navarrete, Enrique G, Hu, Shijun, Wang, Li, Lee, Andrew, Pavlovic, Aleksandra, Lin, Shin, Chen, Rui, Hajjar, Roger J, Snyder, Michael P, Dolmetsch, Ricardo E, Butte, Manish J, Ashley, Euan A, Longaker, Michael T, Robbins, Robert C, Wu, Joseph C

“…Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure, dilated cardiomyopathy (DCM) is the most common form of…”
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Blood vessels in a dish: the evolution, challenges, and potential of vascularized tissues and organoids by Nwokoye, Peter N, Abilez, Oscar J

“…Vascular pathologies are prevalent in a broad spectrum of diseases, necessitating a deeper understanding of vascular biology, particularly in overcoming the…”
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Vascular anastomosis using controlled phase transitions in poloxamer gels by Chang, Edward I, Galvez, Michael G, Glotzbach, Jason P, Hamou, Cynthia D, El-ftesi, Samyra, Rappleye, C Travis, Sommer, Kristin-Maria, Rajadas, Jayakumar, Abilez, Oscar J, Fuller, Gerald G, Longaker, Michael T, Gurtner, Geoffrey C

“…By exploiting the thermoreversible properties of the US Food and Drug Administration–approved poloxamer 407 (triblock polymer) and 2-octylcyanoacrylate…”
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Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue by Ardehali, Reza, Ali, Shah R., Inlay, Matthew A., Abilez, Oscar J., Chen, Michael Q., Blauwkamp, Timothy A., Yazawa, Masayuki, Gong, Yongquan, Nusse, Roeland, Drukker, Micha, Weissman, Irving L.

“…A goal of regenerative medicine is to identify cardiovascular progenitors from human ES cells (hESCs) that can functionally integrate into the human heart…”
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Label-free electrophysiological cytometry for stem cell-derived cardiomyocyte clusters by Myers, Frank B, Zarins, Christopher K, Abilez, Oscar J, Lee, Luke P

“…Stem cell therapies hold great promise for repairing tissues damaged due to disease or injury. However, a major obstacle facing this field is the difficulty in…”
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CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells by Skelton, Rhys J.P., Brady, Bevin, Khoja, Suhail, Sahoo, Debashis, Engel, James, Arasaratnam, Deevina, Saleh, Kholoud K., Abilez, Oscar J., Zhao, Peng, Stanley, Edouard G., Elefanty, Andrew G., Kwon, Murray, Elliott, David A., Ardehali, Reza

“…The generation of tissue-specific cell types from human embryonic stem cells (hESCs) is critical for the development of future stem cell-based regenerative…”
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Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies by Tzatzalos, Evangeline, Abilez, Oscar J., Shukla, Praveen, Wu, Joseph C.

“…Engineered heart tissue has emerged as a personalized platform for drug screening. With the advent of induced pluripotent stem cell (iPSC) technology,…”
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Iliac fixation inhibits migration of both suprarenal and infrarenal aortic endografts by Benharash, Peyman, MD, Lee, Jason T., MD, Abilez, Oscar J., MD, Crabtree, Tami, MS, Bloch, Daniel A., PhD, Zarins, Christopher K., MD

“…Objective To evaluate the role of iliac fixation in preventing migration of suprarenal and infrarenal aortic endografts. Methods Quantitative image analysis…”
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An in Vivo miRNA Delivery System for Restoring Infarcted Myocardium by Yang, Huaxiao, Qin, Xulei, Wang, Huiyuan, Zhao, Xin, Liu, Yonggang, Wo, Hung-Ta, Liu, Chun, Nishiga, Masataka, Chen, Haodong, Ge, Jing, Sayed, Nazish, Abilez, Oscar J, Ding, Dan, Heilshorn, Sarah C, Li, Kai

“…A major challenge in myocardial infarction (MI)-related heart failure treatment using microRNA is the efficient and sustainable delivery of miRNAs into…”
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iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy by Kodo, Kazuki, Ong, Sang-Ging, Jahanbani, Fereshteh, Termglinchan, Vittavat, Hirono, Keiichi, InanlooRahatloo, Kolsoum, Ebert, Antje D., Shukla, Praveen, Abilez, Oscar J., Churko, Jared M., Karakikes, Ioannis, Jung, Gwanghyun, Ichida, Fukiko, Wu, Sean M., Snyder, Michael P., Bernstein, Daniel, Wu, Joseph C.

“…Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in children and its pathogenesis has been associated with the developmental…”
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Computational optogenetics: A novel continuum framework for the photoelectrochemistry of living systems by Wong, Jonathan, Abilez, Oscar J., Kuhl, Ellen

“…Electrical stimulation is currently the gold standard treatment for heart rhythm disorders. However, electrical pacing is associated with technical limitations…”
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Bioengineering methods for vascularizing organoids by Nwokoye, Peter N., Abilez, Oscar J.

“…Organoids, self-organizing three-dimensional (3D) structures derived from stem cells, offer unique advantages for studying organ development, modeling…”
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Transcriptome analysis of non human primate-induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer culture vs. 3D engineered heart tissue by Yang, Huaxiao, Shao, Ningyi, Holmström, Alexandra, Zhao, Xin, Chour, Tony, Chen, Haodong, Itzhaki, Ilanit, Wu, Haodi, Ameen, Mohamed, Cunningham, Nathan J, Tu, Chengyi, Zhao, Ming-Tao, Tarantal, Alice F, Abilez, Oscar J, Wu, Joseph C

“…Abstract Aims Stem cell therapy has shown promise for treating myocardial infarction via re-muscularization and paracrine signalling in both small and large…”
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