Search Results - "Abid, Md Ruhul"

Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium by Shafique, Ehtesham, Torina, Anali, Reichert, Karla, Colantuono, Bonnie, Nur, Nasifa, Zeeshan, Khawaja, Ravichandran, Vani, Liu, Yuhong, Feng, Jun, Benjamin, Laura E, Irani, Kaikobad, Harrington, Elizabeth O, Sellke, Frank W, Abid, Md Ruhul

“…There are conflicting reports on the role of reactive oxygen species (ROS) i.e. beneficial vs. harmful, in vascular endothelium. Here, we aim to examine…”
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FOXO1-Mediated Activation of Akt Plays a Critical Role in Vascular Homeostasis by Dharaneeswaran, Harita, Abid, Md Ruhul, Yuan, Lei, Dupuis, Dylan, Beeler, David, Spokes, Katherine C, Janes, Lauren, Sciuto, Tracey, Kang, Peter M, Jaminet, Shou-Ching S, Dvorak, Ann, Grant, Marianne A, Regan, Erzsébet Ravasz, Aird, William C

“…RATIONALE:Forkhead box-O transcription factors (FoxOs) transduce a wide range of extracellular signals, resulting in changes in cell survival, cell cycle…”
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NADPH Oxidase Activity Selectively Modulates Vascular Endothelial Growth Factor Signaling Pathways by Abid, Md. Ruhul, Spokes, Katherine C., Shih, Shou-Ching, Aird, William C.

“…Vascular endothelial growth factor (VEGF) and reactive oxygen species (ROS) play critical roles in vascular physiology and pathophysiology. We have…”
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Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src by Lee, Monica, Choy, Wing C, Abid, Md Ruhul

“…ADPH oxidase-derived reactive oxygen species (ROS) play important roles in redox homeostasis and signal transduction in endothelial cells (ECs). We previously…”
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Endothelium-Dependent Coronary Vasodilatation Requires NADPH Oxidase–Derived Reactive Oxygen Species by Feng, Jun, Damrauer, Scott M, Lee, Monica, Sellke, Frank W, Ferran, Christiane, Abid, Md. Ruhul

“…OBJECTIVE—To determine the functional significance of physiological reactive oxygen species (ROS) levels in endothelium-dependent nitric oxide (NO)-mediated…”
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Vascular Endothelial Growth Factor Activates PI3K/Akt/Forkhead Signaling in Endothelial Cells by Abid, Md Ruhul, Guo, Shaodong, Minami, Takashi, Spokes, Katherine C, Ueki, Kohjiro, Skurk, Carsten, Walsh, Kenneth, Aird, William C

“…OBJECTIVE—Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that promotes endothelial cell (EC) survival, migration, and…”
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Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK by Shafique, Ehtesham, Choy, Wing C, Liu, Yuhong, Feng, Jun, Cordeiro, Brenda, Lyra, Arthur, Arafah, Mohammed, Yassin-Kassab, Abdulmounem, Zanetti, Arthus V D, Clements, Richard T, Bianchi, Cesario, Benjamin, Laura E, Sellke, Frank W, Abid, Md Ruhul

“…Age-associated decline in cardiovascular function is believed to occur from the deleterious effects of reactive oxygen species (ROS). However, failure of…”
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Vascular Endothelial Growth Factor- and Thrombin-induced Termination Factor, Down Syndrome Critical Region-1, Attenuates Endothelial Cell Proliferation and Angiogenesis by Minami, Takashi, Horiuchi, Keiko, Miura, Mai, Abid, Md. Ruhul, Takabe, Wakako, Noguchi, Noriko, Kohro, Takahide, Ge, Xijin, Aburatani, Hiroyuki, Hamakubo, Takao, Kodama, Tatsuhiko, Aird, William C.

“…Activation and dysfunction of the endothelium underlie many vascular disorders including atherosclerosis, tumor growth, and inflammation. Endothelial cell…”
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Forkhead Transcription Factors Inhibit Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia by Abid, Md Ruhul, Yano, Kiichiro, Guo, Shaodong, Patel, Virendra I, Shrikhande, Gautam, Spokes, Katherine C, Ferran, Christiane, Aird, William C

“…Vascular smooth muscle cell (VSMC) proliferation and migration contribute significantly to atherosclerosis, postangioplasty restenosis, and transplant…”
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Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways by Minami, Takashi, Abid, Md Ruhul, Zhang, Jie, King, George, Kodama, Tatsuhiko, Aird, William C

“…We recently demonstrated that thrombin induces the expression of vascular adhesion molecule-1 (VCAM-1) in endothelial cells by an NF-kappaB- and GATA-dependent…”
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Intracellular Ca2+ can compensate for the lack of NADPH oxidase‐derived ROS in endothelial cells by Lee, Monica, Spokes, Katherine C., Aird, William C., Abid, Md. Ruhul

“…The aim of the present study is to determine the role of intracellular Ca2+ in VEGF signaling. We demonstrate that reduction in Ca2+ by chelating compound…”
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A Novel Class of Vascular Endothelial Growth Factor-responsive Genes That Require Forkhead Activity for Expression by Abid, Md. Ruhul, Shih, Shu-Ching, Otu, Hasan H., Spokes, Katherine C., Okada, Yoshiaki, Curiel, David T., Minami, Takashi, Aird, William C.

“…Recently, we have shown that transient phosphorylation and inhibition of the pro-apoptotic transcription factor, forkhead, by vascular endothelial growth…”
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Hepatocyte Growth Factor Inhibits VEGF-Forkhead–Dependent Gene Expression in Endothelial Cells by Abid, Md. Ruhul, Nadeau, Robert J, Spokes, Katherine C, Minami, Takashi, Li, Dan, Shih, Shou-Ching, Aird, William C

“…OBJECTIVE—Recently, we reported that the forkhead transcription factor, FKHR/FOXO1, is required for vascular endothelial growth factor (VEGF)–mediated…”
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VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd by Sun, Zuyue, Li, Xiujuan, Massena, Sara, Kutschera, Simone, Padhan, Narendra, Gualandi, Laura, Sundvold-Gjerstad, Vibeke, Gustafsson, Karin, Choy, Wing Wen, Zang, Guangxiang, Quach, My, Jansson, Leif, Phillipson, Mia, Abid, Md Ruhul, Spurkland, Anne, Claesson-Welsh, Lena

“…Regulation of vascular endothelial (VE) growth factor (VEGF)-induced permeability is critical in physiological and pathological processes. We show that…”
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Translational Regulation of Ribonucleotide Reductase by Eukaryotic Initiation Factor 4E Links Protein Synthesis to the Control of DNA Replication by Abid, M R, Li, Y, Anthony, C, De Benedetti, A

“…Ribonucleotide reductase synthesizes dNDPs, a specific and limiting step in DNA synthesis, and can participate in neoplastic transformation when overexpressed…”
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Vascular endocan is preferentially expressed in tumor endothelium by Abid, Md. Ruhul, Yi, Xianjin, Yano, Kiichiro, Shih, Shu-Ching, Aird, William C.

“…Endothelial cell phenotypes are differentially regulated between different sites of the vascular tree. We tested the hypothesis that endocan, a novel soluble…”
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The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP by Skurk, Carsten, Maatz, Henrike, Kim, Hyo-Soo, Yang, Jiang, Abid, Md Ruhul, Aird, William C., Walsh, Kenneth

“…FLICE-inhibitory protein (FLIP) is a homolog of caspase-8 that lacks catalytic activity and has been shown to be important in protecting endothelial cells from…”
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Vascular Endothelial Growth Factor-mediated Induction of Manganese Superoxide Dismutase Occurs through Redox-dependent Regulation of Forkhead and IκB/NF-κB by Abid, Md. Ruhul, Schoots, Ivo G., Spokes, Katherine C., Wu, Sheng-Qian, Mawhinney, Christina, Aird, William C.

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Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells by Séguin, Chantal, Abid, Md Ruhul, Spokes, Katherine C, Aird, William C

“…Thrombomodulin (TM) is a cell surface anticoagulant glycoprotein that plays a key role in the protein C pathway. TM expression in endothelial cells may be…”
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Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells by Séguin, Chantal, Abid, Md. Ruhul, Spokes, Katherine C, Schoots, Ivo G, Brkovic, Alexandre, Sirois, Martin G, Aird, William C

“…Abstract Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis, as well as for arterial and venous thrombosis. However, the…”
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