Search Results - "Abi‐Ghanem, Charly"

Roles of Progesterone, Testosterone and Their Nuclear Receptors in Central Nervous System Myelination and Remyelination by Ghoumari, Abdel Mouman, Abi Ghanem, Charly, Asbelaoui, Narimène, Schumacher, Michael, Hussain, Rashad

“…Progesterone and testosterone, beyond their roles as sex hormones, are neuroactive steroids, playing crucial regulatory functions within the nervous system…”
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Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin by Bielecki, Bartosz, Mattern, Claudia, Ghoumari, Abdel M., Javaid, Sumaira, Smietanka, Kaja, Ghanem, Charly Abi, Mhaouty-Kodja, Sakina, Ghandour, M. Said, Baulieu, Etienne-Emile, Franklin, Robin J. M., Schumacher, Michael, Traiffort, Elisabeth

“…Lost myelin can be replaced after injury or during demyelinating diseases in a regenerative process called remyelination. In the central nervous system (CNS),…”
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YAP and TAZ regulate remyelination in the central nervous system by Hong, Jiayue, Kirkland, Julia M., Acheta, Jenica, Marziali, Leandro N., Beck, Brianna, Jeanette, Haley, Bhatia, Urja, Davis, Grace, Herron, Jacob, Roué, Clémence, Abi‐Ghanem, Charly, Feltri, M. Laura, Zuloaga, Kristen L., Bechler, Marie E., Poitelon, Yannick, Belin, Sophie

“…Abstract Myelinating cells are sensitive to mechanical stimuli from their extracellular matrix. Ablation of YAP and TAZ mechanotransducers in Schwann cells…”
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Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor by Abi Ghanem, Charly, Degerny, Cindy, Hussain, Rashad, Liere, Philippe, Pianos, Antoine, Tourpin, Sophie, Habert, René, Macklin, Wendy B, Schumacher, Michael, Ghoumari, Abdel M

“…The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. Here, we show that these sex…”
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Role of a Contactin multi‐molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS by Dubessy, Anne‐Laure, Mazuir, Elisa, Rappeneau, Quentin, Ou, Sokounthie, Abi Ghanem, Charly, Piquand, Kevin, Aigrot, Marie‐Stéphane, Thétiot, Melina, Desmazières, Anne, Chan, Eric, Fitzgibbon, Matt, Fleming, Mark, Krauss, Raul, Zalc, Bernard, Ranscht, Barbara, Lubetzki, Catherine, Sol‐Foulon, Nathalie

“…The fast and reliable propagation of action potentials along myelinated fibers relies on the clustering of voltage‐gated sodium channels at nodes of Ranvier…”
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Correction to: Interplay between androgen and CXCR4 chemokine signaling in myelin repair by Asbelaoui, Narimene, Abi-Ghanem, Charly, Schlecht-Louf, Geraldine, Oukil, Hania, Degerny, Cindy, Brain Bank, The Netherlands, Schumacher, Michael, Ghoumarir, Abdel Mouman

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High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner by Gannon, Olivia J, Robison, Lisa S, Salinero, Abigail E, Abi-Ghanem, Charly, Mansour, Febronia M, Kelly, Richard D, Tyagi, Alvira, Brawley, Rebekah R, Ogg, Jordan D, Zuloaga, Kristen L

“…Approximately 70% of Alzheimer's disease (AD) patients have co-morbid vascular contributions to cognitive impairment and dementia (VCID); this highly prevalent…”
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Sex‐specific effects of high‐fat diet on cognitive impairment in a mouse model of VCID by Salinero, Abigail E., Robison, Lisa S., Gannon, Olivia J., Riccio, David, Mansour, Febronia, Abi‐Ghanem, Charly, Zuloaga, Kristen L.

“…Mid‐life metabolic disease (ie, obesity, diabetes, and prediabetes) causes vascular dysfunction and is a risk factor for vascular contributions to cognitive…”
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Androgens’ effects on cerebrovascular function in health and disease by Abi-Ghanem, Charly, Robison, Lisa S, Zuloaga, Kristen L

“…Abstract Androgens affect the cerebral vasculature and may contribute to sex differences in cerebrovascular diseases. Men are at a greater risk for stroke and…”
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Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease by Robison, Lisa S, Gannon, Olivia J, Thomas, Melissa A, Salinero, Abigail E, Abi-Ghanem, Charly, Poitelon, Yannick, Belin, Sophie, Zuloaga, Kristen L

“…Abstract Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s disease (AD), likely contributing to disturbances in feeding…”
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CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries by Abi-Ghanem, Charly, Jonnalagadda, Deepa, Chun, Jerold, Kihara, Yasuyuki, Ranscht, Barbara

“…The destruction of the myelin sheath that encircles axons leads to impairments of nerve conduction and neuronal dysfunctions. A major demyelinating disorder is…”
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Menopause Diminishes Female Protection against Vascular Contributions to Cognitive Impairment and Dementia by Gannon, Olivia J., Naik, Janvie S., Abi‐Ghanem, Charly, Mansour, Febronia, Salinero, Abigail E., Riccio, David, Kelly, Richard D., Brooks, Heddwen L., Zuloaga, Kristen L.

“…Around mid‐life, ovarian production of estrogen stops in a sex‐specific endocrine transition called menopause. While most women who have dementia are…”
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Effects of menopause on cognitive deficits in a mouse model of metabolic disease by Salinero, Abigail E, Abi‐Ghanem, Charly, Kelly, Richard D, Riccio, David, Gannon, Olivia J, Venkataganesh, Harini, Zuloaga, Kristen L

“…Background By 2025, it is estimated that nearly 20% of the U.S. population will be post‐menopausal women. Menopause accelerates metabolic disease, a major…”
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Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia by Gannon, Olivia J, Naik, Janvie S, Riccio, David, Mansour, Febronia M, Abi-Ghanem, Charly, Salinero, Abigail E, Kelly, Richard D, Brooks, Heddwen L, Zuloaga, Kristen L

“…The vast majority of women with dementia are post-menopausal. Despite clinical relevance, menopause is underrepresented in rodent models of dementia. Before…”
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The impacts of menopause on a mouse model of co‐morbid metabolic syndrome and Alzheimer’s disease by Abi‐Ghanem, Charly, Salinero, Abigail E, Gannon, Olivia J, Riccio, David, Mansour, Febronia, Kelly, Richard D, Kordit, David, Wang, Matthew, Kyaw, Nyi‐Rein, Cirrito, John R, Zuloaga, Kristen L

“…Background Alzheimer’s disease (AD) is the leading cause of disability and 5th cause of death in people over 65 years of age. Approximately 2/3 of AD patients…”
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Interplay between androgen and CXCR4 chemokine signaling in myelin repair by Asbelaoui, Narimène, Abi-Ghanem, Charly, Schlecht-Louf, Géraldine, Oukil, Hania, Schumacher, Michael, Ghoumari, Abdel Mouman

“…In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling demyelinating…”
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High-Fat Diet-Induced Obesity Causes Sex-Specific Deficits in Adult Hippocampal Neurogenesis in Mice by Robison, Lisa S, Albert, Nathan M, Camargo, Lauren A, Anderson, Brian M, Salinero, Abigail E, Riccio, David A, Abi-Ghanem, Charly, Gannon, Olivia J, Zuloaga, Kristen L

“…Adult hippocampal neurogenesis (AHN) is suppressed by high-fat (HF) diet and metabolic disease, including obesity and type 2 diabetes. Deficits in AHN may…”
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Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease by Robison, Lisa S, Gannon, Olivia J, Salinero, Abigail E, Abi-Ghanem, Charly, Kelly, Richard D, Riccio, David A, Mansour, Febronia M, Zuloaga, Kristen L

“…Alzheimer's disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampal and cortical areas; however, several…”
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Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID by Abi-Ghanem, Charly, Salinero, Abigail E, Kordit, David, Mansour, Febronia M, Kelly, Richard D, Venkataganesh, Harini, Kyaw, Nyi-Rein, Gannon, Olivia J, Riccio, David, Fredman, Gabrielle, Poitelon, Yannick, Belin, Sophie, Kopec, Ashley M, Robison, Lisa S, Zuloaga, Kristen L

“…Damage to the cerebral vasculature can lead to vascular contributions to cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads…”
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Effects of high fat diet on metabolic health vary by age of menopause onset by Salinero, Abigail E, Venkataganesh, Harini, Abi-Ghanem, Charly, Riccio, David, Kelly, Richard D, Gannon, Olivia J, Sura, Avi, Brooks, Heddwen L, Zuloaga, Damian G, Zuloaga, Kristen L

“…Menopause accelerates metabolic dysfunction, including (pre-)diabetes, obesity and visceral adiposity. However, the effects of endocrine vs. chronological…”
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