Search Results - "Abeywardena, Mahinda Y."

Cardioprotective actions of grape polyphenols by Leifert, Wayne R, Abeywardena, Mahinda Y

“…Abstract The aim of this review is to discuss the accumulating evidence that suggests that grape extracts and purified grape polyphenols possess a diverse…”
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Consumption of an Oil Palm Fruit Extract Promotes Large Bowel Health in Rats by Conlon, Michael A, Sambanthamurthi, Ravigadevi, Tan, Yew Ai, Sundram, Kalyana, Fairus, Syed, Abeywardena, Mahinda Y

“…Oil palm fruit is widely used for edible oils, but the health benefits of other components are relatively unknown. We examined if consuming a polyphenol-rich…”
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Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats by Abeywardena, Mahinda Y, Adams, Michael, Dallimore, Julie, Kitessa, Soressa M

“…Stearidonic acid (SDA; C18:4n-3) has been suggested as an alternative to fish oil (FO) for delivering health benefits of C ≥ 20 long-chain n-3 polyunsaturated…”
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Butyrylated starch increases large bowel butyrate levels and lowers colonic smooth muscle contractility in rats by Bajka, Balazs H, Clarke, Julie M, Topping, David. L, Cobiac, Lynne, Abeywardena, Mahinda Y, Patten, Glen S

“…Abstract The short-chain fatty acids acetate, propionate, and butyrate are produced by colonic bacterial fermentation of carbohydrates. Butyrate is important…”
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Lipid-Induced Insulin Resistance in Skeletal Muscle: The Chase for the Culprit Goes from Total Intramuscular Fat to Lipid Intermediates, and Finally to Species of Lipid Intermediates by Kitessa, Soressa M, Abeywardena, Mahinda Y

“…The skeletal muscle is the largest organ in the body. It plays a particularly pivotal role in glucose homeostasis, as it can account for up to 40% of the body…”
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Naturally Derived Micelles for Rapid in Vitro Screening of Potential Cholesterol-Lowering Bioactives by Kirana, Chandra, Rogers, Paul F, Bennett, Louise E, Abeywardena, Mahinda Y, Patten, Glen S

“…A high plasma cholesterol level, especially low-density lipoprotein cholesterol, indicates increased risk of cardiovascular diseases. Plasma cholesterol levels…”
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Inhibition of Angiotensin Converting Enzyme, Angiotensin II Receptor Blocking, and Blood Pressure Lowering Bioactivity across Plant Families by Patten, Glen S., Abeywardena, Mahinda Y., Bennett, Louise E.

“…Hypertension is a major risk factor for coronary heart disease, kidney disease, and stroke. Interest in medicinal or nutraceutical plant bioactives to reduce…”
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The Inhibition of Metabolic Inflammation by EPA Is Associated with Enhanced Mitochondrial Fusion and Insulin Signaling in Human Primary Myotubes by Sergi, Domenico, Luscombe-Marsh, Natalie, Heilbronn, Leonie K, Birch-Machin, Mark, Naumovski, Nenad, Lionetti, Lilla', Proud, Christopher G, Abeywardena, Mahinda Y, O'Callaghan, Nathan

“…Sustained fuel excess triggers low-grade inflammation that can drive mitochondrial dysfunction, a pivotal defect in the pathogenesis of insulin resistance in…”
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Short term effects of palm-tocotrienol and palm-carotenes on vascular function and cardiovascular disease risk: A randomised controlled trial by Stonehouse, Welma, Brinkworth, Grant D, Thompson, Campbell H, Abeywardena, Mahinda Y

“…Abstract Background and aims In vitro , ex vivo and animal studies suggest palm-based tocotrienols and carotenes enhance vascular function, but limited data in…”
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Naturally occurring anthocyanin cyanidin-3-rutinoside possesses inherent vasorelaxant actions and prevents methylglyoxal-induced vascular dysfunction in rat aorta and mesenteric arterial bed by Thilavech, Thavaree, Abeywardena, Mahinda Y., Adams, Michael, Dallimore, Julie, Adisakwattana, Sirichai

“…•Low concentrations of C3R promote endothelium-dependent vasodilation.•Intravenous administration of C3R induces hypotension in anesthetized rat.•Pre-treatment…”
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Inhibition of Low-Density Lipoprotein Oxidation and Up-Regulation of Low-Density Lipoprotein Receptor in HepG2 Cells by Tropical Plant Extracts by Salleh, Mohd. Nizar, Runnie, Irine, Roach, Paul D, Mohamed, Suhaila, Abeywardena, Mahinda Y

“…Twelve edible plant extracts rich in polyphenols were screened for their potential to inhibit oxidation of low-density lipoprotein (LDL) in vitro and to…”
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Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity by Leifert, Wayne R, Abeywardena, Mahinda Y

“…Abstract Accumulating evidence suggests that grape seed and wine polyphenol extracts possess a diverse array of actions and may be beneficial in the prevention…”
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Dietary fish oil preserves cardiac function in the hypertrophied rat heart by McLennan, Peter L., Abeywardena, Mahinda Y., Dallimore, Julie A., Raederstorff, Daniel

“…Regular fish or fish oil intake is associated with a low incidence of heart failure clinically, and fish oil-induced reduction in cardiac remodelling seen in…”
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Effects of casoxin 4 on morphine inhibition of small animal intestinal contractility and gut transit in the mouse by Patten, Glen S, Head, Richard J, Abeywardena, Mahinda Y

“…Chronic opioid analgesia has the debilitating side-effect of constipation in human patients. The major aims of this study were to: 1) characterize the…”
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Cyanidin-3-rutinoside alleviates methylglyoxal-induced cardiovascular abnormalities in the rat by Thilavech, Thavaree, Abeywardena, Mahinda Y., Dallimore, Julie, Adams, Michael, Adisakwattana, Sirichai

“…[Display omitted] •C3R reduced plasma MG and AGEs accumulation in aortic tissue of MG-fed rats.•C3R restored vascular dysfunction in isolated vessels of MG-fed…”
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Bioequivalence of n-3 fatty acids from microencapsulated fish oil formulations in human subjects by Sanguansri, Luz, Augustin, Mary Ann, Lockett, Trevor J., Abeywardena, Mahinda Y., Royle, Peter J., Mano, Mark T., Patten, Glen S.

“…Fish oil n-3 fatty acids (FA) have known health benefits. Microencapsulation stabilises and protects fish oil from oxidation, enabling its incorporation into…”
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Cardiovascular biology of interleukin-6 by Abeywardena, Mahinda Y, Leifert, Wayne R, Warnes, Kirsty E, Varghese, Jose N, Head, Richard J

“…Interleukin-6 (IL-6) is a multifunctional pro-inflammatory cytokine that is tightly regulated and expressed at low levels in healthy individuals. Increased…”
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Effect of oil palm phenolics on gastrointestinal transit, contractility and motility in the rat by Patten, Glen S., Abeywardena, Mahinda Y., Sundram, Kalyana, Tan, Yew Ai, Sambanthamurthi, Ravigadevi

“…•Oil palm phenolics preparation increased the contractile strength of distal colon and accelerated motility.•Confirmed a resistant starch as high amylose maize…”
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Dietary fats, carbohydrates and vascular disease: Sri Lankan perspectives by Abeywardena, Mahinda Y.

“…The recent estimates for mortality from cardio and cerebrovascular diseases (CVD) for Sri Lanka––524 deaths per 100 000––is higher than that observed in many…”
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Site Specific Delivery of Microencapsulated Fish Oil to the Gastrointestinal Tract of the Rat by Patten, Glen S, Augustin, Mary Ann, Sanguansri, Luz, Head, Richard J, Abeywardena, Mahinda Y

“…The aim of this study was to design food grade matrices to deliver microencapsulated fish oil to the large bowel of the rat where the potential exists to…”
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