Search Results - "Abernathy, Matthew"

The Efficacy, Effectiveness, and Efficiency of Integrated QTc Assessment: Rationalizing Approaches to New Drug Modalities by Abernathy, Matthew M., Leishman, Derek J.

“…After nearly 3 decades of regulatory activity concerning new drugs' potential for delayed cardiac repolarization an integrated risk assessment paradigm for…”
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Return to SENDer: The Submitted Electronic Data for Nonclinical Cardiovascular Studies is Not Facilitating Transparency, Translation or Innovation by Abernathy, Matthew M., Best, Derek D., Leishman, Derek J.

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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept by Coskun, Tamer, Urva, Shweta, Roell, William C., Qu, Hongchang, Loghin, Corina, Moyers, Julie S., O’Farrell, Libbey S., Briere, Daniel A., Sloop, Kyle W., Thomas, Melissa K., Pirro, Valentina, Wainscott, David B., Willard, Francis S., Abernathy, Matthew, Morford, LaRonda, Du, Yu, Benson, Charles, Gimeno, Ruth E., Haupt, Axel, Milicevic, Zvonko

“…With an increasing prevalence of obesity, there is a need for new therapies to improve body weight management and metabolic health. Multireceptor agonists in…”
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Revisiting the hERG safety margin after 20 years of routine hERG screening by Leishman, Derek J., Abernathy, Matthew M., Wang, Evan B.

“…It has been two decades since screening new molecules and potential clinical drug candidates against the hERG potassium channel became a routine part of safety…”
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A comparison of the performance of contemporary, historical, and cross-lab controls in QTc assessment in conscious nonhuman primates by Abernathy, Matthew M., Best, Derek D., Leishman, Derek J.

“…Cardiovascular safety pharmacology and toxicology studies include vehicle control animals in most studies. Electrocardiogram data on common vehicles is…”
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A “one‐step” approach to heart rate correction and statistical analysis applied to conscious dog QTc studies by Best, Derek D., Abernathy, Matthew M., Leishman, Derek J.

“…A “one‐step” method which combined the heart rate correction and statistical analysis for conscious nonhuman primate (NHP) QTc assessment was recently…”
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Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation by Holdsworth, David, Best, Derek D., Haist, Katarina, O'Donohue, Kyle, Phillips, Anson, Abernathy, Matthew M., Roche, Brian, Leishman, Derek J.

“…The number of animals used in a nonhuman primate (NHP) in vivo QTc assessment conducted as part of the safety pharmacology (SP) studies on a potential new drug…”
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Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure by Verdino, Petra, Lee, Stacey L., Cooper, Fariba N., Cottle, Steven R., Grealish, Patrick F., Hu, Charlie C., Meyer, Catalina M., Lin, Joanne, Copeland, Victoria, Porter, Gina, Schroeder, Richard L., Thompson, Tyran D., Porras, Leah L., Dey, Asim, Zhang, Hong Y., Beebe, Emily C., Matkovich, Scot J., Coskun, Tamer, Balciunas, Aldona M., Ferrante, Andrea, Siegel, Robert, Malherbe, Laurent, Bivi, Nicoletta, Paavola, Chad D., Hansen, Ryan J., Abernathy, Matthew M., Nwosu, Sylvia O., Carr, Molly C., Heuer, Josef G., Wang, Xiaojun

“…Background and Purpose Chronic heart failure, a progressive disease with limited treatment options currently available, especially in heart failure with…”
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The Safety Pharmacology of Auditory Function by Abernathy, Matthew M

“…Safety pharmacology satisfies a key requirement in the process of drug development. Safety pharmacology studies are required to assess the impact of a new…”
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The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis by Boulay, Emmanuel, Miraucourt, Loïs S., Pugsley, Michael K., Abernathy, Matthew M., Chui, Ray, Dalton, Jill, Demers, Marjorie, Dybdal, Noel, Gazaille, Elissa, Greiter-Wilke, Andrea, Hoffmann, Peter, Huang, Hai, LaDuke, Carrie, Norton, Kevin, Pierson, Jennifer B., Reeves, Isabelle, Roche, Brian, Rossman, Eric I., Schultze, Albert E., Tang, Hai-Ming, Wisialowski, Todd, Authier, Simon

“…Characterization of the incidence of spontaneous arrhythmias to identify possible drug-related effects is often an important part of the analysis in safety…”
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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective by Reynolds, Vincent L., Butler, Paul, Abernathy, Matthew M., Aschenbrenner, Laura, Best, Derek D., Blank, Jim, Crosby, Meredith, Custer, Laura, Escobar, Patricia A., Kolaja, Kyle, Moggs, Jonathan, Shuey, Dana, Snyder, Chelsea, Van Vleet, Terry, Zhou, Junguo, Hart, Timothy K.

“…Pharmaceutic products designed to perturb the function of epigenetic modulators have been approved by regulatory authorities for treatment of advanced cancer…”
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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19 by Delaunois, Annie, Abernathy, Matthew, Anderson, Warren D., Beattie, Kylie A., Chaudhary, Khuram W., Coulot, Julie, Gryshkova, Vitalina, Hebeisen, Simon, Holbrook, Mark, Kramer, James, Kuryshev, Yuri, Leishman, Derek, Lushbough, Isabel, Passini, Elisa, Redfern, Will S., Rodriguez, Blanca, Rossman, Eric I., Trovato, Cristian, Wu, Caiyun, Valentin, Jean‐Pierre

“…We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of…”
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Generative machine learning with tensor networks: Benchmarks on near-term quantum computers by Wall, Michael L., Abernathy, Matthew R., Quiroz, Gregory

“…Noisy, intermediate-scale quantum (NISQ) computing devices have become an industrial reality in the last few years, and cloud-based interfaces to these devices…”
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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium by Boulay, Emmanuel, Abernathy, Matthew M., Chui, Ray, Friedrichs, Gregory S., Gendron-Parra, Nicolas, Greiter-Wilke, Andrea, Guillon, Jean-Michel, Koerner, John E., Menard, Ariane, Steidl-Nichols, Jill, Pierson, Jennifer, Pugsley, Michael K., Rossman, Eric I., Strauss, David, Troncy, Eric, Valentin, Jean-Pierre, Wisialowski, Todd, Authier, Simon

“…Introduction: Based on the ICH S7B and E14 guidance documents, QT interval (QTc) is used as the primary in vivo biomarker to assess the risk of drug-induced…”
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An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation by Authier, Simon, Abernathy, Matthew M., Correll, Krystle, Chui, Ray W., Dalton, Jill, Foley, C. Michael, Friedrichs, Gregory S., Koerner, John E., Kallman, Mary-Jeanne, Pannirselvam, Malar, Redfern, William S., Urmaliya, Vijay, Valentin, Jean-Pierre, Wisialowski, Todd, Zabka, Tanja S., Pugsley, Michael K.

“…Introduction: The Safety Pharmacology Society (SPS) conducted a membership survey to examine industry practices related mainly to cardiovascular (CV) safety…”
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Order, disorder and mixing: The atomic structure of amorphous mixtures of titania and tantala by Bassiri, Riccardo, Abernathy, Matthew R., Liou, Franklin, Mehta, Apurva, Gustafson, Eric K., Hart, Martin J., Isa, Hafizah N., Kim, Namjun, Lin, Angie C., MacLaren, Ian, Martin, Iain W., Route, Roger K., Rowan, Sheila, Shyam, Badri, Stebbins, Jonathan F., Fejer, Martin M.

“…The atomic structure of mixtures of titania (TiO2) and tantala (Ta2O5) ion-beam sputtered amorphous thin film coatings at various post-deposition annealing…”
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The failure to detect drug-induced sensory loss in standard preclinical studies by Gauvin, David V., Abernathy, Matthew M., Tapp, Rachel L., Yoder, Joshua D., Dalton, Jill A., Baird, Theodore J.

“…Over the years a number of drugs have been approved for human use with limited signs of toxicity noted during preclinical risk assessment study designs but…”
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Utility of the auditory brainstem response evaluation in non-clinical drug safety evaluations by Abernathy, Matthew M., Gauvin, David V., Tapp, Rachel L., Yoder, Joshua D., Baird, Theodore J.

“…The Food and Drug Administration (FDA) requires thorough evaluation of the potential safety hazards of all new drugs, food additives, and therapeutic devices…”
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An Overview of Research into Low Internal Friction Optical Coatings by the Gravitational Wave Detection Community by Abernathy, Matthew Robert, Liu, Xiao, Metcalf, Thomas H.

“…The direct detection of gravitational waves by ground-based interferometric gravitational wave detectors in recent years has opened a new window of the…”
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Annealing and Extended Etching Improve a Torsional Resonator for Thin Film Internal Friction Measurements by Metcalf, Thomas, Liu, Xiao, Abernathy, Matthew Robert

“…We evaluate two methods to improve the background internal friction of the Double Paddle Oscillator (DPO), which has a nominal low temperature value of Q-1 ≈…”
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