Search Results - "Abell, D."

Engineering the Slow Photon Effect in Photoactive Nanoporous Anodic Alumina Gradient-Index Filters for Photocatalysis by Lim, Siew Yee, Law, Cheryl Suwen, Markovic, Marijana, Kirby, Jason K, Abell, Andrew D, Santos, Abel

“…In this study, we explore for the first time the capabilities of nanoporous anodic alumina gradient-index filters (NAA-GIFs) functionalized with titanium…”
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Nanoporous Anodic Alumina Photonic Crystals for Optical Chemo- and Biosensing: Fundamentals, Advances, and Perspectives by Law, Cheryl Suwen, Lim, Siew Yee, Abell, Andrew D, Voelcker, Nicolas H, Santos, Abel

“…Optical sensors are a class of devices that enable the identification and/or quantification of analyte molecules across multiple fields and disciplines such as…”
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Unraveling the Interplay of Backbone Rigidity and Electron Rich Side-Chains on Electron Transfer in Peptides: The Realization of Tunable Molecular Wires by Horsley, John R, Yu, Jingxian, Moore, Katherine E, Shapter, Joe G, Abell, Andrew D

“…Electrochemical studies are reported on a series of peptides constrained into either a 310-helix (1–6) or β-strand (7–9) conformation, with variable numbers of…”
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Photoregulation of α-Chymotrypsin Activity by Spiropyran-Based Inhibitors in Solution and Attached to an Optical Fiber by Zhang, Xiaozhou, Heng, Sabrina, Abell, Andrew. D.

“…Here the synthesis and characterization of a new class of spiropyran‐based protease inhibitor is reported that can be reversibly photoswitched between an…”
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Boronate probes for the detection of hydrogen peroxide release from human spermatozoa by Purdey, Malcolm S., Connaughton, Haley S., Whiting, Sara, Schartner, Erik P., Monro, Tanya M., Thompson, Jeremy G., Aitken, R. John, Abell, Andrew D.

“…Human spermatozoa are compromised by production of reactive oxygen species (ROS), and detection of ROS in spermatozoa is important for the diagnosis of male…”
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A Dual Sensor for pH and Hydrogen Peroxide Using Polymer-Coated Optical Fibre Tips by Purdey, Malcolm S, Thompson, Jeremy G, Monro, Tanya M, Abell, Andrew D, Schartner, Erik P

“…This paper demonstrates the first single optical fibre tip probe for concurrent detection of both hydrogen peroxide (H₂O₂) concentration and pH of a solution…”
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Optical Fibre-Enabled Photoswitching for Localised Activation of an Anti-Cancer Therapeutic Drug by Palasis, Kathryn A., Lokman, Noor A., Quirk, Bryden C., Adwal, Alaknanda, Scolaro, Loretta, Huang, Weikun, Ricciardelli, Carmela, Oehler, Martin K., McLaughlin, Robert A., Abell, Andrew D.

“…Local activation of an anti-cancer drug when and where needed can improve selectivity and reduce undesirable side effects. Photoswitchable drugs can be…”
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Elucidating Synergies of Single‐Atom Catalysts in a Model Thin Film Photoelectrocatalyst to Maximize Hydrogen Evolution Reaction by Zhao, Zichu, Law, Cheryl Suwen, Zhao, Yanzhang, Baron Jaimez, Jairo Alberto, Talebian‐Kiakalaieh, Amin, Li, Haobo, Ran, Jingrun, Jiao, Yan, Abell, Andrew D., Santos, Abel

“…Realization of the full potential of single‐atom photoelectrocatalysts in sustainable energy generation requires careful consideration of the design of the…”
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Single‐molecule Conductance and Electrochemical Measurements of Electron Transfer in β‐strand Peptides by Mo, Wenjing, Horsley, John R., Li, Xiaohui, Sheng, Shiqi, Jong, Bianca, Abell, Andrew D., Hong, Wenjing, Yu, Jingxian

“…A series of β‐strand peptides comprising redox‐active amino acids in the P2 position were synthesized to investigate the effects of electron‐rich side chains…”
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Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes by Thompson, Andrew P, Salaemae, Wanisa, Pederick, Jordan L, Abell, Andrew D, Booker, Grant W, Bruning, John B, Wegener, Kate L, Polyak, Steven W

“…The penultimate step in the biosynthesis of biotin is the closure of the ureido heterocycle in a reaction requiring a nucleoside triphosphate (NTP). In…”
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Uncovering the link between the SpnIII restriction modification system and LuxS in Streptococcus pneumoniae meningitis isolates by Agnew, Hannah N, Atack, John M, Fernando, Ann R D, Waters, Sophie N, van der Linden, Mark, Smith, Erin, Abell, Andrew D, Brazel, Erin B, Paton, James C, Trappetti, Claudia

“…is capable of randomly switching their genomic DNA methylation pattern between six distinct bacterial subpopulations (A-F) via recombination of a type 1…”
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Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from Aspergillus fumigatus by Vandborg, Bethiney C., Horsfall, Aimee J., Pederick, Jordan L., Abell, Andrew D., Bruning, John B.

“…Invasive fungal infections (IFIs) are prevalent in immunocompromised patients. Due to alarming levels of increasing resistance in clinical settings, new drugs…”
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Structure guided design of biotin protein ligase inhibitors for antibiotic discovery by Paparella, Ashleigh S, Soares da Costa, Tatiana P, Yap, Min Y, Tieu, William, Wilce, Matthew C J, Booker, Grant W, Abell, Andrew D, Polyak, Steven W

“…Biotin protein ligase (BPL) represents a promising target for the discovery of new antibacterial chemotherapeutics. Here we review the central role of BPL for…”
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A Rationally Designed Reversible 'Turn-Off' Sensor for Glutathione by Heng, Sabrina, Zhang, Xiaozhou, Pei, Jinxin, Abell, Andrew D

“…γ-Glutamyl-cysteinyl-glycine (GSH) plays a critical role in maintaining redox homeostasis in biological systems and a decrease in its cellular levels is…”
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Structural Optimization of Photoswitch Ligands for Surface Attachment of α-Chymotrypsin and Regulation of Its Surface Binding by Pearson, David, Abell, Andrew D.

“…A modified gold surface that allows photoregulated binding of α‐chymotrypsin has previously been reported. Here the development of this surface is reported,…”
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Molecular Modeling, Synthesis, and Biological Evaluation of Macrocyclic Calpain Inhibitors by Abell, Andrew D, Jones, Matthew A, Coxon, James M, Morton, James D, Aitken, Steven G, McNabb, Stephen B, Lee, Hannah Y.-Y, Mehrtens, Janna M, Alexander, Nathan A, Stuart, Blair G, Neffe, Axel T, Bickerstaffe, Roy

“…The design and elaboration of a series of macrocyclic templates that exhibit a propensity to adopt a β-strand-like peptide-backbone conformation led to potent…”
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Synthesis of Trisubstituted Imidazoles by Palladium-Catalyzed Cyclization of O-Pentafluorobenzoylamidoximes:  Application to Amino Acid Mimetics with a C-Terminal Imidazole by Zaman, Shazia, Mitsuru, Kitamura, Abell, Andrew D

“…1-Benzyl-4-methylimidazoles with a range of substituents at the 2-position are prepared from O-pentafluorobenzoylamidoximes on treatment with catalytic amounts…”
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A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model by Morton, James D, Lee, Hannah Y Y, McDermott, Josh D, Robertson, Lucinda J G, Bickerstaffe, Roy, Jones, Matthew A, Coxon, James M, Abell, Andrew D

“…We used sheep with an autosomal dominant gene for cortical cataract as an animal model to evaluate novel macrocyclic calpain inhibitors with potential for the…”
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A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde by Zhang, X, Bruning, J B, George, J H, Abell, A D

“…Here we describe an NMR and X-ray crystallography-based characterisation of the mechanism by which a new class of macrocyclic peptidomimetic aldehyde inhibits…”
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Improved Photocontrol of α-Chymotrypsin Activity: Peptidomimetic Trifluoromethylketone Photoswitch Enzyme Inhibitors by Pearson, David, Alexander, Nathan, Abell, Andrew D.

“…A series of peptidomimetic trifluoromethylketones containing the photoisomerisable azobenzene group have been synthesised, photoisomerised and assayed against…”
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