Estrogen therapy attenuates adiposity markers in spontaneously hypertensive rats

Abstract Ovarian hormones modulate the metabolism of adipose cells and present a protective effect against hypertension. The aim of this study was to compare the effect of estradiol on adiposity markers in spontaneously hypertensive rats. Ovariectomized spontaneously hypertensive rats treated with e...

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Published in:	Metabolism, clinical and experimental Vol. 61; no. 8; pp. 1100 - 1107
Main Authors:	Abeles, Eva das Graças, Cordeiro, Letícia Maria de Souza, Martins, Almir de Sousa, Pesquero, Jorge Luiz, dos Reis, Adelina Martha, Andrade, Silvia Passos, Botion, Leida Maria
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-08-2012 Elsevier
Subjects:	Adipocytes - drug effects Adipocytes - metabolism Adiposity - drug effects Adrenergic beta-Agonists - pharmacology Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - metabolism Blood and lymphatic vessels Blood Glucose - drug effects Blood Glucose - metabolism Cardiology. Vascular system Down-Regulation - drug effects Endocrinology & Metabolism Estradiol - administration & dosage Estradiol - metabolism Estradiol - pharmacology Estrogens - administration & dosage Estrogens - metabolism Estrogens - pharmacology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Isoproterenol - pharmacology Lipolysis - drug effects Lipoprotein Lipase - drug effects Lipoprotein Lipase - metabolism Medical sciences Ovariectomy PPAR alpha - drug effects PPAR alpha - metabolism PPAR gamma - drug effects PPAR gamma - metabolism Rats Rats, Inbred SHR Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Up-Regulation - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems insulin ISO periuterine LPL Peri spontaneously hypertensive rat isoproterenol INS Vehicle PPAR E 2 lipoprotein lipase RT-PCR real time – polymerase chain reaction Veh Mes peroxisome proliferator-activated receptor SHR estradiol mesenteric E2 Hypertension Adipose tissue Rat Rodentia Estrogen Cardiovascular disease Marker Ovarian hormone Vertebrata Mammalia Treatment Adiposity Animal Sex steroid hormone Endocrinology
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Summary:	Abstract Ovarian hormones modulate the metabolism of adipose cells and present a protective effect against hypertension. The aim of this study was to compare the effect of estradiol on adiposity markers in spontaneously hypertensive rats. Ovariectomized spontaneously hypertensive rats treated with estradiol (5 μg/100 g/day), three weeks after ovariectomy, presented decreased blood pressure and insulin levels and increased hepatic glycogen content. Periuterine or mesenteric adipocytes from treated animals were smaller as compared to vehicle treated group, whereas no differences were observed in relation to the number of cells. Basal rates of glycerol release were higher only in periuterine adipocytes of treated rats. The increment of glycerol release over basal values in response to isoproterenol was 400% and 440%, 283% and 330% for vehicle and estradiol treated periuterine and mesenteric adipocytes, respectively. The estradiol treated group was more sensitive to insulin inhibition of isoproterenol-stimulated lipolysis than the control animals. The lipoprotein lipase activity decreased after treatment, only in periuterine adipose tissue. Estradiol administration increased basal and insulin-stimulated rates of glucose transport in adipocytes of both sites, although the values obtained by periuterine were higher than those observed for mesenteric adipocytes. Both adipose tissues from treated animals exhibited a decreased expression of the peroxisome proliferator-activated receptor-γ, but an increased expression of peroxisome proliferator-activated receptor-α in liver. These findings suggest that estrogen administration attenuates adiposity markers of spontaneously hypertensive rats as a result of the decreased expression levels of peroxisome proliferator-activated receptor-γ in adipose tissue and increased expression of peroxisome proliferator-activated receptor-α in liver.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0026-0495 1532-8600
DOI:	10.1016/j.metabol.2011.12.015