Hepatic Stellate Cells and Fibrogenesis in Hepatitis C Virus Infection: An Ultrastructural Insight

Hepatic Stellate Cells and Fibrogenesis in Hepatitis C Virus Infection: An Ultrastructural Insight

An ultrastructural quantitative assessment of hepatic stellate cells (HSCs) was made in relation to hepatic fibrosis, apoptotic cellular changes, intracellular fat deposition, circulating inflammatory cells in the sinusoids, and the necroinflammatory activity in liver specimens of 33 patients proven...

Full description

Saved in:
Bibliographic Details
Published in:Ultrastructural pathology Vol. 34; no. 2; pp. 62 - 67
Main Authors: Mansy, Soheir S., ElKhafif, Nagwa A., AbelFatah, Ahmed S., Yehia, Hoda A., Mostafa, Ibrahim
Format: Journal Article
Language:English
Published: England Informa UK Ltd 2010
Taylor & Francis
Subjects:
Apoptosis - physiology
electron microscopy
fibrogenesis
Hepacivirus - genetics
Hepacivirus - immunology
Hepacivirus - isolation & purification
hepatic fibrosis
hepatic stellate cells (HSCs)
Hepatic Stellate Cells - chemistry
Hepatic Stellate Cells - ultrastructure
hepatitis C virus
Hepatitis C, Chronic - metabolism
Hepatitis C, Chronic - pathology
Humans
Lipids - analysis
Liver Cirrhosis - metabolism
Liver Cirrhosis - pathology
Microscopy, Electron, Transmission - methods
myofibroblast-like
RNA, Viral - analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An ultrastructural quantitative assessment of hepatic stellate cells (HSCs) was made in relation to hepatic fibrosis, apoptotic cellular changes, intracellular fat deposition, circulating inflammatory cells in the sinusoids, and the necroinflammatory activity in liver specimens of 33 patients proven to be positive for hepatitis C virus (HCV)-RNA by polymerase chain reaction with the intention that electron microscopy may throw more light on the role of HSCs in the complicated process of fibrogenesis. A detailed review concerning these parameters and observed evidence suggesting the potential properties of HSCs to recycle cellular debris into collagen fibers are reported.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0191-3123
1521-0758
DOI:10.3109/01913120903506645