Search Results - "Abel, Steven M"

Small RNA sequencing of field Culex mosquitoes identifies patterns of viral infection and the mosquito immune response by Abel, Steven M., Hong, Zhenchen, Williams, Desiree, Ireri, Sally, Brown, Michelle Q., Su, Tianyun, Hung, Kim Y., Henke, Jennifer A., Barton, John P., Le Roch, Karine G.

“…Mosquito-borne disease remains a significant burden on global health. In the United States, the major threat posed by mosquitoes is transmission of…”
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Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics by Inversen, Lars, Tu, Hsiung-Lin, Lin, Wan-Chen, Christensen, Sune M., Abel, Steven M., Iwig, Jeff, Wu, Hung-Jen, Gureasko, Jodi, Rhodes, Christopher, Petit, Rebecca S., Hansen, Scott D., Thill, Peter, Yu, Cheng-Han, Stamou, Dimitrios, Chakraborty, Arup K., Kuriyan, John, Groves, Jay T.

“…Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple…”
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A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration by Alves, Daiane S, Westerfield, Justin M, Shi, Xiaojun, Nguyen, Vanessa P, Stefanski, Katherine M, Booth, Kristen R, Kim, Soyeon, Morrell-Falvey, Jennifer, Wang, Bing-Cheng, Abel, Steven M, Smith, Adam W, Barrera, Francisco N

“…Misregulation of the signaling axis formed by the receptor tyrosine kinase (RTK) EphA2 and its ligand, ephrinA1, causes aberrant cell-cell contacts that…”
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The Membrane Environment Can Promote or Suppress Bistability in Cell Signaling Networks by Abel, Steven M, Roose, Jeroen P, Groves, Jay T, Weiss, Arthur, Chakraborty, Arup K

“…Many key biochemical reactions that mediate signal transduction in cells occur at the cell membrane, yet how the two-dimensional membrane environment…”
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Membrane-mediated interactions between hinge-like particles by Li, Bing, Abel, Steven M

“…Adsorption of nanoparticles on a membrane can give rise to interactions between particles, mediated by membrane deformations, that play an important role in…”
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Analysis of Network Topologies Underlying Ethylene Growth Response Kinetics by Prescott, Aaron M, McCollough, Forest W, Eldreth, Bryan L, Binder, Brad M, Abel, Steven M

“…Most models for ethylene signaling involve a linear pathway. However, measurements of seedling growth kinetics when ethylene is applied and removed have…”
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Morphometric analysis of actin networks by Akenuwa, Oghosa H., Gu, Jinmo, Nebenführ, Andreas, Abel, Steven M.

“…The organization of cytoskeletal elements is pivotal for coordinating intracellular transport in eukaryotic cells. Several quantitative measures based on image…”
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Protein clusters on the T cell surface may suppress spurious early signaling events by Chung, Woo, Abel, Steven M, Chakraborty, Arup K

“…T cells play an important role in the adaptive immune system, quickly activating effector functions in response to small numbers of antigenic peptides but…”
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Particle Deformability Enables Control of Interactions between Membrane-Anchored Nanoparticles by Nambiar, Nikhil, Loyd, Zachary A., Abel, Steven M.

“…Nanoparticles adsorbed on a membrane can induce deformations of the membrane that give rise to effective interactions between the particles. Previous studies…”
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Correction: Protein Clusters on the T Cell Surface May Suppress Spurious Early Signaling Events by Chung, Woo, Abel, Steven M., Chakraborty, Arup K.

“…Woo Chung1, Steven M. Abel1, Arup K. Chakraborty1,2,3,4* 1 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts,…”
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Organization and dynamics of cross-linked actin filaments in confined environments by Akenuwa, Oghosa H., Abel, Steven M.

“…The organization of the actin cytoskeleton is impacted by the interplay between physical confinement, features of cross-linking proteins, and deformations of…”
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Catch Bonds at T Cell Interfaces: Impact of Surface Reorganization and Membrane Fluctuations by Pullen, Robert H., Abel, Steven M.

“…Catch bonds are characterized by average lifetimes that initially increase with increasing tensile force. Recently, they have been implicated in T cell…”
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Mechanical feedback enables catch bonds to selectively stabilize scanning microvilli at T-cell surfaces by Pullen, 3rd, Robert H, Abel, Steven M

“…T-cells use microvilli to search the surfaces of antigen-presenting cells for antigenic ligands. The active motion of scanning microvilli provides a…”
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Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse by Zhang, Zihan, Gaetjens, Thomas K, Ou, Jin, Zhou, Qiong, Yu, Yanqi, Mallory, D Paul, Abel, Steven M, Yu, Yan

“…Phagocytosis is a critical immune function for infection control and tissue homeostasis. During phagocytosis, pathogens are internalized and degraded in…”
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Confined semiflexible polymers suppress fluctuations of soft membrane tubes by Mirzaeifard, Sina, Abel, Steven M

“…We use Monte Carlo computer simulations to investigate tubular membrane structures with and without semiflexible polymers confined inside. At small values of…”
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Kinetic theories of dynamics and persistent caging in a one-dimensional lattice gas by Abel, Steven M, Steve Tse, Ying-Lung, Andersenb, Hans C

“…The one-dimensional, single-occupancy lattice gas exhibits highly cooperative particle motion and provides an interesting challenge for theoretical methods…”
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Equilibrium binding of isolated and in-plasma high-density lipoproteins (HDLs) to polystyrene nanoparticles by Anozie, Uche C., Quigley, Kevin J., Prescott, Aaron, Abel, Steven M., Dalhaimer, Paul

“…It is hypothesized that plasma proteins bind nanoparticles in vivo as they do in vitro, forming a protein corona. The resulting decorated nanoparticle surface…”
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A Cdc42 GEF, Gef1, through endocytosis organizes F-BAR Cdc15 along the actomyosin ring and promotes concentric furrowing by Onwubiko, Udo N, Mlynarczyk, Paul J, Wei, Bin, Habiyaremye, Julius, Clack, Amanda, Abel, Steven M, Das, Maitreyi E

“…During cytokinesis, fission yeast coordinates actomyosin ring constriction with septum ingression, resulting in concentric furrow formation by a poorly defined…”
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Protein Molecular Dynamics Simulations with Approximate QM: What Can We Learn? by Irle, Stephan, Vuong, Van Q, Elayyan, Mouhmad H, Talipov, Marat R, Abel, Steven M

“…Classical force fields are essential for computer simulations of proteins and are typically parameterized to reproduce secondary and tertiary structure of…”
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Macromolecular Crowding Induces Spatial Correlations That Control Gene Expression Bursting Patterns by Norred, S. Elizabeth, Caveney, Patrick M, Chauhan, Gaurav, Collier, Lauren K, Collier, C. Patrick, Abel, Steven M, Simpson, Michael L

“…Recent superresolution microscopy studies in E. coli demonstrate that the cytoplasm has highly variable local concentrations where macromolecular crowding…”
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