Search Results - "Abel, Clifford"

Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression by Comba, Andrea, Faisal, Syed M., Dunn, Patrick J., Argento, Anna E., Hollon, Todd C., Al-Holou, Wajd N., Varela, Maria Luisa, Zamler, Daniel B., Quass, Gunnar L., Apostolides, Pierre F., Abel, Clifford, Brown, Christine E., Kish, Phillip E., Kahana, Alon, Kleer, Celina G., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.

“…Intra-tumoral heterogeneity is a hallmark of glioblastoma that challenges treatment efficacy. However, the mechanisms that set up tumor heterogeneity and tumor…”
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The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications by Faisal, Syed M., Comba, Andrea, Varela, Maria L., Argento, Anna E., Brumley, Emily, Abel, Clifford, Castro, Maria G., Lowenstein, Pedro R.

“…Glioblastoma (GBM), an aggressive high-grade glial tumor, is resistant to therapy and has a poor prognosis due to its universal recurrence rate. GBM cells…”
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Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis by Comba, Andrea, Varela, Maria Luisa, Faisal, Syed M., Abel, Clifford C., Argento, Anna E., Al-Holou, Wajd N., Hollon, Todd C., Perelman, Jacqueline D., Dunn, Patrick J., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.

“…Development of spatial-integrative pre-clinical models is needed for glioblastoma, which are heterogenous tumors with poor prognosis. Here, we present an…”
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TMIC-18. ROLE OF DISCOIDIN DOMAIN RECEPTORS (DDR1/DDR2) IN SENSITIZATION OF GLIOMAS TOWARDS RADIOTHERAPY by Syed, Mohammad Faisal, Comba, Andrea, Varela, Maria Luisa, Argento, Anna, Brumley, Emily, Abel, Clifford, Castro, Maria, Lowenstein, Pedro

“…Glioblastoma (GBM), a high-grade glial tumor, is highly aggressive and is characterized by intra-tumoral heterogeneity and widespread infiltration, impairing…”
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TMIC-62. INHIBITION OF TUMOR-ASSOCIATED COL1A1 MATRIX ARRESTS GLIOMA MESENCHYMAL TRANSFORMATION AND REPROGRAMS THE TUMOR MICROENVIRONMENT by Comba, Andrea, Faisal, Syed M, Varela, Maria Luisa, Argento, Anna, Dunn, Patrick, Abel, Clifford, Hollon, Todd, Al-Holou, Wajd, Zamler, Daniel, Quass, Gunnar, Apostolides, Pierre, Kish, Phillip, Perelman, Jacqueline, Jacobs, Nicole, Kahana, Alon, Brown, Christine, Kleer, Celina, Motsch, Sebastien, Castro, Maria, Lowenstein, Pedro

“…Tumor mesenchymal transformation (MT) is a hallmark of high-grade gliomas. The mesenchymal state is associated with specific changes related to cell adhesion,…”
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Abstract 5835: Targeting discoidin domain receptor 1 (DDR1) reverses glioma immune suppression by remodeling collagen fiber architecture by Faisal, Syed M., Comba, Andrea, Varela, Maria L., Argento, Anna E., Brumley, Emily, West, Molly E., Haase, Santiago, Mujeeb, Anzar A., Abel, Clifford, Barissi, Marcus N., Clewner, Jarred E., Stack, Brooklyn, Abbud, Grace A., Castro, Maria G., Lowenstein, Pedro R.

“…Glioblastoma (GBM) is the most aggressive and immunosuppressive form of brain tumor, and its treatment remains a large, unmet medical need. Recently, we…”
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TMIC-03. TARGETING THE COLLAGEN RECEPTOR DDR1 PROMOTES ANTI-GLIOMA IMMUNITY BY REMODELING COLLAGEN FIBER ARCHITECTURE by Faisal, Syed M, Varela, Maria, Comba, Andrea, Argento, Anna, West, Molly, Brumley, Emily, Abel II, Clifford, Clewner, Jarred, Stack, Brooklyn, Haase, Santiago, Mujeeb, Anzar, Banerjee, Kaushik, Barissi, Marcus, Abbud, Grace, Castro, Maria, Lowenstein, Pedro

“…Glioblastoma (GBM), characterized by its aggressive nature and profound immunosuppression, poses a significant therapeutic challenge with limited treatment…”
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