Search Results - "Abel, Alex M."

Natural Killer Cells: Development, Maturation, and Clinical Utilization by Abel, Alex M, Yang, Chao, Thakar, Monica S, Malarkannan, Subramaniam

“…Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising…”
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Role of the tumour microenvironment in bladder cancer pathogenesis and value of the reverse translational approach: a tale of two species by Ahmed, Basant H., Zdyrski, Christopher, Cheville, John, Rancilio, Nicholas, Abel, Alex M., Wierson, Wesley A., McGill, Jodi L., Mochel, Jonathan P., Allenspach, Karin

“…Background Bladder cancer is a significant malignancy in humans and canines, with high death rates and devastating clinical symptoms. Despite significant…”
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IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells by Abel, Alex M, Tiwari, Aradhana A, Gerbec, Zachary J, Siebert, Jason R, Yang, Chao, Schloemer, Nathan J, Dixon, Kate J, Thakar, Monica S, Malarkannan, Subramaniam

“…Natural killer (NK) cells are innate lymphocytes that play essential roles in mediating antitumor immunity. NK cells respond to various inflammatory stimuli…”
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IQGAP1: Insights into the function of a molecular puppeteer by Abel, Alex M., Schuldt, Kristina M., Rajasekaran, Kamalakannan, Hwang, David, Riese, Matthew J., Rao, Sridhar, Thakar, Monica S., Malarkannan, Subramaniam

“…•Scaffolins play an essential role in coordinating signaling events in cells.•As a scaffolin, IQGAP1 curbs, compartmentalizes, and coordinates signaling…”
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In Vivo Assessment of NK Cell-Mediated Cytotoxicity by Adoptively Transferred Splenocyte Rejection by Schloemer, Nathan J, Abel, Alex M, Thakar, Monica S, Malarkannan, Subramaniam

“…NK cells are innate lymphocytes that are vital to clearance of virally infected or malignantly transformed cells. Assessment of the cytotoxic response is an…”
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Protein kinase R (PKR) plays a pro-viral role in porcine reproductive and respiratory syndrome virus (PRRSV) replication by modulating viral gene transcription by Wang, Xiuqing, Zhang, Hanmo, Abel, Alex M, Nelson, Eric

“…Protein kinase R (PKR) is involved in apoptotic cell death and antiviral activities in response to many virus infections. To reveal the role of PKR in the…”
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MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection by Dixon, Kate J., Siebert, Jason R., Wang, Dandan, Abel, Alex M., Johnson, Kaitlin E., Riese, Matthew J., Terhune, Scott S., Tarakanova, Vera L., Thakar, Monica S., Malarkannan, Subramaniam

“…•We generated a novel NK cell-specific conditional knockout mouse for MyD88 cKO to define the cell-intrinsic functions of MyD88 in NK cells.•MyD88 cKO mice…”
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Role of phosphatidylinositol 3-kinase (PI3K) and Akt1 kinase in porcine reproductive and respiratory syndrome virus (PRRSV) replication by Wang, Xiuqing, Zhang, Hanmo, Abel, Alex M, Young, Alan J, Xie, Liji, Xie, Zhixun

“…We have previously reported that inhibition of phosphatidylinositol 3-kinase (PI3K) reduces porcine reproductive and respiratory syndrome (PRRSV) replication…”
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Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression by Sirpilla, Olivia, Sakemura, R. Leo, Hefazi, Mehrdad, Huynh, Truc N., Can, Ismail, Girsch, James H., Tapper, Erin E., Cox, Michelle J., Schick, Kendall J., Manriquez-Roman, Claudia, Yun, Kun, Stewart, Carli M., Ogbodo, Ekene J., Kimball, Brooke L., Mai, Long K., Gutierrez-Ruiz, Omar L., Rodriguez, Makena L., Gluscevic, Martina, Larson, Daniel P., Abel, Alex M., Wierson, Wesley A., Olivier, Gloria, Siegler, Elizabeth L., Kenderian, Saad S.

“…Allogeneic mesenchymal stromal cells (MSCs) are a safe treatment option for many disorders of the immune system. However, clinical trials using MSCs have shown…”
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The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9 by Fisher, J B, Peterson, J, Reimer, M, Stelloh, C, Pulakanti, K, Gerbec, Z J, Abel, A M, Strouse, J M, Strouse, C, McNulty, M, Malarkannan, S, Crispino, J D, Milanovich, S, Rao, S

“…Acute myelogenous leukemia (AML) is a high-risk hematopoietic malignancy caused by a variety of mutations, including genes encoding the cohesin complex. Recent…”
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Impact of Kindlin-3 in NK Cell-Mediated Anti-Tumor Cytotoxicity and Inflammatory Cytokine Production by Schloemer, Nathan J., Abel, Alex M, Thakar, Monica S, Ma, Yan-Qing, Malarkannan, Subramaniam

“…Natural Killer (NK) cells are innate lymphocytes that play a central role in anti-viral and anti-tumor responses through direct cytotoxicity and production of…”
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The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9 by Fisher, Joseph B., Peterson, Jonathan, Reimer, Michael, Stelloh, Cary, Pulakanti, Kirthi, Gerbec, Zachary, Abel, Alex M, Strouse, Jennifer, Strouse, Christopher, McNulty, Maureen, Malarkannan, Subramaniam, Crispino, John, Milanovich, Samuel, Rao, Sridhar

“…Acute myelogenous leukemia (AML) is a high-risk hematopoietic malignancy with a poor prognosis. Developing novel treatments for AML has been difficult due to…”
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