Search Results - "Abed, Dhulfiqar"

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents by Abed, Dhulfiqar Ali, Goldstein, Melanie, Albanyan, Haifa, Jin, Huijuan, Hu, Longqin

“…The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein…”
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Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation by Abed, Dhulfiqar Ali, Lee, Sumi, Wen, Xia, Ali, Ahmed R., Mangipudy, Vaibhav, Aleksunes, Lauren M., Hu, Longqin

“…[Display omitted] The protein–protein interaction (PPI) between kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2…”
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Green synthesis of metronidazole or clindamycin-loaded hexagonal zinc oxide nanoparticles from Ziziphus extracts and its antibacterial activity by Habeeb, Saba Abdulmunem, Hammadi, Asmaa H, Abed, Dhulfiqar, Al-Jibouri, Lena Fadhil

“…Green chemistry has become a fruitful approach for the synthesis of semiconductors and nanoparticles with various applications. Herein, we synthesized ZnO…”
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Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction by Abed, Dhulfiqar Ali, Lee, Sumi, Hu, Longqin

“…[Display omitted] The Keap1–Nrf2–ARE system represents a crucial antioxidant defense mechanism that protects cells against reactive oxygen species. Targeting…”
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Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N′-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction by Lee, Sumi, Abed, Dhulfiqar Ali, Nguyen, Mai-Uyen, Verzi, Michael P., Hu, Longqin

“…The Keap1-Nrf2-ARE pathway plays an important role in responding to oxidative stress and maintaining the redox homeostasis. Small molecule inhibitors targeting…”
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Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N′-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction by Lee, Sumi, Ali, Ahmed R., Abed, Dhulfiqar Ali, Nguyen, Mai-Uyen, Verzi, Michael P., Hu, Longqin

“…The Keap1-Nrf2-ARE signaling pathway is an attractive therapeutic target for the prevention and treatment of oxidative stress-associated diseases by activating…”
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Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N′-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction by Abed, Dhulfiqar.Ali, Ali, Ahmed R., Lee, Sumi, Nguyen, Mai-Uyen, Verzi, Michael P., Hu, Longqin

“…Direct inhibition of the protein-protein interaction (PPI) between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2…”
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WITHDRAWN: Synthesis, characterization, and cytotoxicity assessment of biotinylated carbon dots nanoparticles as camptothecin delivery system by Talib, Ali B., Mohammed, Mohammed H., Ali Abed, Dhulfiqar

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Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction by Lee, Sumi, Abed, Dhulfiqar Ali, Beamer, Lesa J, Hu, Longqin

“…The transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), plays a major role in regulating the antioxidant defense system through the…”
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Design, Synthesis, and Biological Evaluation of Camptothecin Loaded Biotinylated Cellulose Nanowhiskers as Anticancer Agents

“…Objective: Using biotinylated cellulose nanowhiskers (CNWs), we designed and synthesized a Glutathione (GSH) sensitive- Camptothecin (CPT) prodrug for…”
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Cystatin-C in patients with acute coronary syndrome: Correlation with ventricular dysfunction, and affected coronary vessels by Abed, Dhulfiqar Ali, Jasim, Raad, Al-Hindy, Hayder Abdul-Amir, Obaid, Ammar Waheeb

“…Abstract Objective: This study designed to inspect the circulating levels of Cy/C in patients with ACS and to evaluate the association of Cy/C levels with…”
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Structure-activity Relationships of Small Molecule Direct Inhibitors of Keap1-Nrf2 Interaction by Abed, Dhulfiqar Ali

“…The Keap1–Nrf2–ARE system represents a crucial antioxidant defense mechanism that protects cells against oxidative stress-related diseases and inflammation…”
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