Search Results - "Abeba Zewdu"

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression by Casadei, Lucia, Calore, Federica, Creighton, Chad J, Guescini, Michele, Batte, Kara, Iwenofu, O Hans, Zewdu, Abeba, Braggio, Danielle A, Bill, Kate Lynn, Fadda, Paolo, Lovat, Francesca, Lopez, Gonzalo, Gasparini, Pierluigi, Chen, James L, Kladney, Raleigh D, Leone, Gustavo, Lev, Dina, Croce, Carlo M, Pollock, Raphael E

“…Despite the development of combined modality treatments against liposarcoma in recent years, a significant proportion of patients respond only modestly to such…”
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β-catenin S45F mutation results in apoptotic resistance by Braggio, Danielle, Zewdu, Abeba, Londhe, Priya, Yu, Peter, Lopez, Gonzalo, Batte, Kara, Koller, David, Costas Casal de Faria, Fernanda, Casadei, Lucia, Strohecker, Anne M., Lev, Dina, Pollock, Raphael E.

“…Wnt/β-catenin signaling is one of the key cascades regulating embryogenesis and tissue homeostasis; it has also been intimately associated with carcinogenesis…”
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Preclinical efficacy of the Wnt/β-catenin pathway inhibitor BC2059 for the treatment of desmoid tumors by Braggio, Danielle Almeida, Costas C de Faria, Fernanda, Koller, David, Jin, Feng, Zewdu, Abeba, Lopez, Gonzalo, Batte, Kara, Casadei, Lucia, Welliver, Meng, Horrigan, Stephen K, Han, Ruolan, Larson, Jeffrey L, Strohecker, Anne M, Pollock, Raphael E

“…Mutation in the CTNNB1 gene, leading to a deregulation of the WTN/β-catenin pathway, is a common feature of desmoid tumors (DTs). Many β-catenin inhibitors…”
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MDM2 Derived from Dedifferentiated Liposarcoma Extracellular Vesicles Induces MMP2 Production from Preadipocytes by Casadei, Lucia, Calore, Federica, Braggio, Danielle A, Zewdu, Abeba, Deshmukh, Ameya A, Fadda, Paolo, Lopez, Gonzalo, Wabitsch, Martin, Song, Chi, Leight, Jennifer L, Grignol, Valerie P, Lev, Dina, Croce, Carlo M, Pollock, Raphael E

“…Dedifferentiated liposarcoma (DDLPS) is frequently diagnosed late, and patients typically respond poorly to treatments. DDLPS is molecularly characterized by…”
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HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST) by Lopez, Gonzalo, Bill, Kate Lynn J, Bid, Hemant Kumar, Braggio, Danielle, Constantino, Dylan, Prudner, Bethany, Zewdu, Abeba, Batte, Kara, Lev, Dina, Pollock, Raphael E

“…HDAC isoform-specific inhibitors may improve the therapeutic window while limiting toxicities. Developing inhibitors against class I isoforms poses…”
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Mocetinostat combined with gemcitabine for the treatment of leiomyosarcoma: Preclinical correlates by Lopez, Gonzalo, Braggio, Danielle, Zewdu, Abeba, Casadei, Lucia, Batte, Kara, Bid, Hemant Kumar, Koller, David, Yu, Peter, Iwenofu, Obiajulu Hans, Strohecker, Anne, Choy, Edwin, Lev, Dina, Pollock, Raphael

“…Leiomyosarcoma (LMS) is a malignant soft tissue sarcoma (STS) with a dismal prognosis following metastatic disease. Chemotherapeutic intervention has…”
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A call for curricular reform: Recognising the importance of race‐based medical education by Inshaar, Hafza, Fadoju, Deborah, Zewdu, Abeba

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catenin S45F mutation results in apoptotic resistance by Braggio, Danielle, Zewdu, Abeba, Londhe, Priya, Yu, Peter, Lopez, Gonzalo, Batte, Kara, Koller, David

“…Wnt/[beta]-catenin signaling is one of the key cascades regulating embryogenesis and tissue homeostasis; it has also been intimately associated with…”
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A Personalized Opioid Prescription Model for Predicting Postoperative Discharge Opioid Needs by Zhang, Kevin K., Blum, Kevin M., Chu, Jacqueline J., Zewdu, Abeba, Janse, Sarah, Skoracki, Roman, Janis, Jeffrey E., Barker, Jenny C.

“…Opioid overprescribing after surgery is common. There is currently no universal predictive tool available to accurately anticipate postdischarge opioid need in…”
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Autophagy inhibition overcomes sorafenib resistance in S45F‐mutated desmoid tumors by Braggio, Danielle, Koller, David, Jin, Feng, Siva, Nanda, Zewdu, Abeba, Lopez, Gonzalo, Batte, Kara, Casadei, Lucia, Welliver, Meng, Strohecker, Anne M., Lev, Dina, Pollock, Raphael E.

“…Background Desmoid tumors (DTs) are rare and understudied fibroblastic lesions that are frequently recurrent and locally invasive. DT patients often experience…”
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Preclinical efficacy of the Wnt/[beta]-catenin pathway inhibitor BC2059 for the treatment of desmoid tumors by Braggio, Danielle Almeida, Costas C. de Faria, Fernanda, Koller, David, Jin, Feng, Zewdu, Abeba, Lopez, Gonzalo, Batte, Kara, Casadei, Lucia, Welliver, Meng, Horrigan, Stephen K, Han, Ruolan, Larson, Jeffrey L, Strohecker, Anne M, Pollock, Raphael E

“…Mutation in the CTNNB1 gene, leading to a deregulation of the WTN/[beta]-catenin pathway, is a common feature of desmoid tumors (DTs). Many [beta]-catenin…”
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Abstract 6213: Extracellular vesicles MDM2 -DNA derived from dedifferentiated liposarcoma induces MMP2 production from preadipocytes by Casadei, Lucia, Calore, Federica, Deshmukh, Ameya, Zewdu, Abeba, Fadda, Paolo, Braggio, Danielle, Wabitsch, Martin, Croce, Carlo M., Lev, Dina, Pollock, Raphael

“…Dedifferentiated liposarcoma (DDLPS) is molecularly characterized by wt p53 and MDM2 gene amplification causing MDM2 protein over-production, the key oncogenic…”
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Abstract 1891: Oncogenic MDM2 -containing exosomes promote pre-metastatic niche establishment by Casadei, Lucia, Calore, Federica, Deshmukh, Ameya, Zewdu, Abeba, Braggio, Danielle A., Fadda, Paolo, Wabitsch, Martin, Lopez, Gonzalo, Leight, Jennifer, Lev, Dina, Croce, Carlo M., Pollock, Raphael E.

“…Extracellular vesicles (EVs) have an important role in the communication between cells for their ability to transfer proteins and other biologically active…”
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Preclinical efficacy of the Wnt/β-catenin pathway inhibitor BC2059 for the treatment of desmoid tumors by Danielle Almeida Braggio, Fernanda Costas C. de Faria, David Koller, Feng Jin, Abeba Zewdu, Gonzalo Lopez, Kara Batte, Lucia Casadei, Meng Welliver, Stephen K. Horrigan, Ruolan Han, Jeffrey L. Larson, Anne M. Strohecker, Raphael E. Pollock

“…Mutation in the CTNNB1 gene, leading to a deregulation of the WTN/β-catenin pathway, is a common feature of desmoid tumors (DTs). Many β-catenin inhibitors…”
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Novel Insights into Dedifferentiated Liposarcoma Pathogenesis: Evaluating the Tumor-Promoting Role of IL6/GP130 Signaling via MDM2 Upregulation by Zewdu, Abeba B

“…Understanding the pathobiological drivers of dedifferentiated liposarcoma (DDLPS) is imperative for efficacious therapies to eventuate. These adipocytic tumors…”
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HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST): e0133302 by Lopez, Gonzalo, Bill, Kate LynnJ, Bid, Hemant Kumar, Braggio, Danielle, Constantino, Dylan, Prudner, Bethany, Zewdu, Abeba, Batte, Kara, Lev, Dina, Pollock, Raphael E

“…Introduction HDAC isoform-specific inhibitors may improve the therapeutic window while limiting toxicities. Developing inhibitors against class I isoforms…”
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