Search Results - "Abe, Takaya"

An inherited mutation in NLRC4 causes autoinflammation in human and mice by Kitamura, Akiko, Sasaki, Yuki, Abe, Takaya, Kano, Hirotsugu, Yasutomo, Koji

“…Autoinflammatory syndromes cause sterile inflammation in the absence of any signs of autoimmune responses. Familial cold autoinflammatory syndrome (FCAS) is…”
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MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors by Shibata, Mikihito, Nakao, Hiromi, Kiyonari, Hiroshi, Abe, Takaya, Aizawa, Shinichi

“…microRNA-9-2 and microRNA-9-3 double-mutant mice demonstrate that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the…”
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The Chiral Looping of the Embryonic Heart Is Formed by the Combination of Three Axial Asymmetries by Honda, Hisao, Abe, Takaya, Fujimori, Toshihiko

“…In mammals and birds, embryonic development of the heart involves conversion of a straight tubular structure into a three-dimensional helical loop, which is a…”
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Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner by Kawano, Yoshinaga, Nakae, Jun, Watanabe, Nobuyuki, Kikuchi, Tetsuhiro, Tateya, Sanshiro, Tamori, Yoshikazu, Kaneko, Mari, Abe, Takaya, Onodera, Masafumi, Itoh, Hiroshi

“…High-fat diet (HFD) induces low-grade chronic inflammation and insulin resistance. However, little is known about the mechanism underlying HFD-induced chronic…”
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Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells by Wu, Quan, Shichino, Yuichi, Abe, Takaya, Suetsugu, Taeko, Omori, Ayaka, Kiyonari, Hiroshi, Iwasaki, Shintaro, Matsuzaki, Fumio

“…The cerebral cortex is formed by diverse neurons generated sequentially from neural stem cells (NSCs). A clock mechanism has been suggested to underlie the…”
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CAMSAP3 maintains neuronal polarity through regulation of microtubule stability by Pongrakhananon, Varisa, Saito, Hiroko, Hiver, Sylvain, Abe, Takaya, Shioi, Go, Meng, Wenxiang, Takeichi, Masatoshi

“…The molecular mechanisms that guide each neuron to become polarized, forming a single axon and multiple dendrites, remain unknown. Here we show that CAMSAP3…”
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Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice by Inada, Kengo, Hagihara, Mitsue, Tsujimoto, Kazuko, Abe, Takaya, Konno, Ayumu, Hirai, Hirokazu, Kiyonari, Hiroshi, Miyamichi, Kazunari

“…The adult brain can flexibly adapt behaviors to specific life-stage demands. For example, while sexually naive male mice are aggressive to the conspecific…”
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Pronuclear Microinjection during S-Phase Increases the Efficiency of CRISPR-Cas9-Assisted Knockin of Large DNA Donors in Mouse Zygotes by Abe, Takaya, Inoue, Ken-ichi, Furuta, Yasuhide, Kiyonari, Hiroshi

“…In CRISPR-Cas9-assisted knockin (KI) in zygotes, a remaining challenge is routinely achieving high-efficiency KI of large (kilobase-sized) DNA elements. Here,…”
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Tracing the origin of hair follicle stem cells by Morita, Ritsuko, Sanzen, Noriko, Sasaki, Hiroko, Hayashi, Tetsutaro, Umeda, Mana, Yoshimura, Mika, Yamamoto, Takaki, Shibata, Tatsuo, Abe, Takaya, Kiyonari, Hiroshi, Furuta, Yasuhide, Nikaido, Itoshi, Fujiwara, Hironobu

“…Tissue stem cells are generated from a population of embryonic progenitors through organ-specific morphogenetic events 1 , 2 . Although tissue stem cells are…”
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CDK1 dependent phosphorylation of hTERT contributes to cancer progression by Yasukawa, Mami, Ando, Yoshinari, Yamashita, Taro, Matsuda, Yoko, Shoji, Shisako, Morioka, Masaki Suimye, Kawaji, Hideya, Shiozawa, Kumiko, Machitani, Mitsuhiro, Abe, Takaya, Yamada, Shinji, Kaneko, Mika K., Kato, Yukinari, Furuta, Yasuhide, Kondo, Tadashi, Shirouzu, Mikako, Hayashizaki, Yoshihide, Kaneko, Shuichi, Masutomi, Kenkichi

“…The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT…”
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IL-33 is a crucial amplifier of innate rather than acquired immunity by Oboki, Keisuke, Ohno, Tatsukuni, Kajiwara, Naoki, Arae, Ken, Morita, Hideaki, Ishii, Akina, Nambu, Aya, Abe, Takaya, Kiyonari, Hiroshi, Matsumoto, Kenji, Sudo, Katsuko, Okumura, Ko, Saito, Hirohisa, Nakae, Susumu, Dinarello, Charles A.

“…IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that is especially involved in Th2-type immune responses. Moreover,…”
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GAREM1 is involved in controlling body mass in mice and humans by Nishino, Tasuku, Abe, Takaya, Kaneko, Mari, Yokohira, Masanao, Yamakawa, Keiko, Imaida, Katsumi, Konishi, Hiroaki

“…The adaptor protein GAREM has two subtypes. Each is involved in Erk activation signaling downstream of the cell growth factor receptor in cultured cells…”
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Relief from neuropathic pain by blocking of the platelet‐activating factor‐pain loop by Shindou, Hideo, Shiraishi, Seiji, Tokuoka, Suzumi M., Takahashi, Yoshikazu, Harayama, Takeshi, Abe, Takaya, Bando, Kana, Miyano, Kanako, Kita, Yoshihiro, Uezono, Yasuhito, Shimizu, Takao

“…ABSTRACT Neuropathic pain resulting from peripheral neuronal damage is largely resistant to treatment with currently available analgesic drugs. Recently, ATP,…”
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Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice by Yanai, Hideyuki, Chiba, Shiho, Hangai, Sho, Kometani, Kohei, Inoue, Asuka, Kimura, Yoshitaka, Abe, Takaya, Kiyonari, Hiroshi, Nishio, Junko, Taguchi-Atarashi, Naoko, Mizushima, Yu, Negishi, Hideo, Grosschedl, Rudolf, Taniguchi, Tadatsugu

“…IFN regulatory factor 3 (IRF3) is a transcription regulator of cellular responses in many cell types that is known to be essential for innate immunity. To…”
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Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes by Yoshida, Shuhei, Nishiyama, Sui, Lister, Lisa, Hashimoto, Shu, Mishina, Tappei, Courtois, Aurélien, Kyogoku, Hirohisa, Abe, Takaya, Shiraishi, Aki, Choudhary, Meenakshi, Nakaoka, Yoshiharu, Herbert, Mary, Kitajima, Tomoya S.

“…Acentrosomal meiosis in oocytes represents a gametogenic challenge, requiring spindle bipolarization without predefined bipolar cues. While much is known about…”
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A unique mode of keratinocyte death requires intracellular acidification by Matsui, Takeshi, Kadono-Maekubo, Nanako, Suzuki, Yoshiro, Furuichi, Yuki, Shiraga, Keiichiro, Sasaki, Hiroyuki, Ishida, Azusa, Takahashi, Sonoko, Okada, Takaharu, Toyooka, Kiminori, Sharif, Jafar, Abe, Takaya, Kiyonari, Hiroshi, Tominaga, Makoto, Miyawaki, Atsushi, Amagai, Masayuki

“…The stratum corneum (SC), the outermost epidermal layer, consists of nonviable anuclear keratinocytes, called corneocytes, which function as a protective…”
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A case report of successful using interventional radiology with covered stents for a vascular access‐related aneurysm by Goto, Yuta, Abe, Takaya, Obara, Wataru

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The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice by Fukuhara, Shigetomo, Simmons, Szandor, Kawamura, Shunsuke, Inoue, Asuka, Orba, Yasuko, Tokudome, Takeshi, Sunden, Yuji, Arai, Yuji, Moriwaki, Kazumasa, Ishida, Junji, Uemura, Akiyoshi, Kiyonari, Hiroshi, Abe, Takaya, Fukamizu, Akiyoshi, Hirashima, Masanori, Sawa, Hirofumi, Aoki, Junken, Ishii, Masaru, Mochizuki, Naoki

“…The bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) promotes the egress of newly formed T cells from the thymus and the release of immature B…”
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Pre-Target Axon Sorting Establishes the Neural Map Topography by Imai, Takeshi, Yamazaki, Takahiro, Kobayakawa, Reiko, Kobayakawa, Ko, Abe, Takaya, Suzuki, Misao, Sakano, Hitoshi

“…Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of…”
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Molecular cell identities in the mediodorsal thalamus of infant mice and marmoset by Onishi, Kohei, Kikuchi, Satomi S., Abe, Takaya, Tokuhara, Tomoko, Shimogori, Tomomi

“…The mediodorsal thalamus (MD) is a higher‐order nucleus located within the central thalamus in many mammalian species. Emerging evidence from MD lesions and…”
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