Search Results - "Abe, Ko"

UNMF: a unified nonnegative matrix factorization for multi-dimensional omics data by Abe, Ko, Shimamura, Teppei

“…Abstract Factor analysis, ranging from principal component analysis to nonnegative matrix factorization, represents a foremost approach in analyzing…”
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DeepKINET: a deep generative model for estimating single-cell RNA splicing and degradation rates by Mizukoshi, Chikara, Kojima, Yasuhiro, Nomura, Satoshi, Hayashi, Shuto, Abe, Ko, Shimamura, Teppei

“…Messenger RNA splicing and degradation are critical for gene expression regulation, the abnormality of which leads to diseases. Previous methods for estimating…”
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LineageVAE: reconstructing historical cell states and transcriptomes toward unobserved progenitors by Majima, Koichiro, Kojima, Yasuhiro, Minoura, Kodai, Abe, Ko, Hirose, Haruka, Shimamura, Teppei

“…Abstract Motivation Single-cell RNA sequencing (scRNA-seq) enables comprehensive characterization of the cell state. However, its destructive nature prohibits…”
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Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis by Abe, Ko, Ikeda, Masataka, Ide, Tomomi, Tadokoro, Tomonori, Miyamoto, Hiroko Deguchi, Furusawa, Shun, Tsutsui, Yoshitomo, Miyake, Ryo, Ishimaru, Kosei, Watanabe, Masatsugu, Matsushima, Shouji, Koumura, Tomoko, Yamada, Ken-Ichi, Imai, Hirotaka, Tsutsui, Hiroyuki

“…Clinical use of doxorubicin (DOX) is limited because of its cardiotoxicity, referred to as DOX-induced cardiomyopathy (DIC). Mitochondria-dependent…”
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Hierarchical non-negative matrix factorization using clinical information for microbial communities by Abe, Ko, Hirayama, Masaaki, Ohno, Kinji, Shimamura, Teppei

“…The human microbiome forms very complex communities that consist of hundreds to thousands of different microorganisms that not only affect the host, but also…”
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Model-based cell clustering and population tracking for time-series flow cytometry data by Minoura, Kodai, Abe, Ko, Maeda, Yuka, Nishikawa, Hiroyoshi, Shimamura, Teppei

“…Modern flow cytometry technology has enabled the simultaneous analysis of multiple cell markers at the single-cell level, and it is widely used in a broad…”
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Model-based clustering for flow and mass cytometry data with clinical information by Abe, Ko, Minoura, Kodai, Maeda, Yuka, Nishikawa, Hiroyoshi, Shimamura, Teppei

“…High-dimensional flow cytometry and mass cytometry allow systemic-level characterization of more than 10 protein profiles at single-cell resolution and provide…”
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A latent allocation model for the analysis of microbial composition and disease by Abe, Ko, Hirayama, Masaaki, Ohno, Kinji, Shimamura, Teppei

“…Establishing the relationship between microbiota and specific diseases is important but requires appropriate statistical methodology. A specialized feature of…”
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A mixture-of-experts deep generative model for integrated analysis of single-cell multiomics data by Minoura, Kodai, Abe, Ko, Nam, Hyunha, Nishikawa, Hiroyoshi, Shimamura, Teppei

“…The recent development of single-cell multiomics analysis has enabled simultaneous detection of multiple traits at the single-cell level, providing deeper…”
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CYBERTRACK2.0: zero-inflated model-based cell clustering and population tracking method for longitudinal mass cytometry data by Minoura, Kodai, Abe, Ko, Maeda, Yuka, Nishikawa, Hiroyoshi, Shimamura, Teppei

“…Abstract Summary Recent advancements in high-dimensional single-cell technologies, such as mass cytometry, enable longitudinal experiments to track dynamics of…”
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Hypoxia‐induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase‐1 in multiple myeloma by Abe, Ko, Ikeda, Sho, Nara, Miho, Kitadate, Akihiro, Tagawa, Hiroyuki, Takahashi, Naoto

“…Background Multiple myeloma (MM) is a hematopoietic malignancy for which proteasome inhibitors have become available in recent years. However, many patients…”
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An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis by Takahashi, Kei, Abe, Ko, Kubota, Shimpei I., Fukatsu, Noriaki, Morishita, Yasuyuki, Yoshimatsu, Yasuhiro, Hirakawa, Satoshi, Kubota, Yoshiaki, Watabe, Tetsuro, Ehata, Shogo, Ueda, Hiroki R., Shimamura, Teppei, Miyazono, Kohei

“…The blood and lymphatic vasculature networks are not yet fully understood even in mouse because of the inherent limitations of imaging systems and…”
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Methotrexate-induced Transient Encephalopathy in an Adolescent and Young Adult Patient with Acute Lymphoblastic Leukemia by Teshima, Kazuaki, Kume, Masaaki, Kondo, Rui, Shibata, Kenichi, Abe, Ko, Aono, Hiroaki, Fushimi, Susumu, Takahashi, Satoshi, Takahashi, Satsuki, Saito, Masahiro, Takahashi, Naoto

“…A 17-year-old girl was diagnosed with acute lymphoblastic leukemia (ALL). After the administration of high-dose methotrexate (MTX) or intrathecal MTX, the…”
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Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity by Tadokoro, Tomonori, Ikeda, Masataka, Abe, Ko, Ide, Tomomi, Miyamoto, Hiroko Deguchi, Furusawa, Shun, Ishimaru, Kosei, Watanabe, Masatsugu, Ishikita, Akihito, Matsushima, Shouji, Koumura, Tomoko, Yamada, Ken-ichi, Imai, Hirotaka, Tsutsui, Hiroyuki

“…Doxorubicin (DOX) is an effective anti-cancer agent for various malignancies. Nevertheless, it has a side effect of cardiotoxicity, referred to as…”
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Hyper-Kamiokande construction status and prospects by Abe, Ko, Tanaka, Hide-Kazu

“…The Hyper-Kamiokande (Hyper-K) project is the world’s leading international neutrino and nucleon decay experiment comprising a next-generation underground…”
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Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury by Miyamoto, Hiroko Deguchi, Ikeda, Masataka, Ide, Tomomi, Tadokoro, Tomonori, Furusawa, Shun, Abe, Ko, Ishimaru, Kosei, Enzan, Nobuyuki, Sada, Masashi, Yamamoto, Taishi, Matsushima, Shouji, Koumura, Tomoko, Yamada, Ken-ichi, Imai, Hirotaka, Tsutsui, Hiroyuki

“…[Display omitted] •It remains unknown how ferroptosis, triggered by excessive lipid peroxides via iron overload, is induced in I/R injury.•GPx4, an endogenous…”
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Survivability and life support in sealed mini-ecosystems with simulated planetary soils by Sato, Tsubasa, Abe, Ko, Koseki, Jun, Seto, Mayumi, Yokoyama, Jun, Akashi, Tomohiro, Terada, Masahiro, Kadowaki, Kohmei, Yoshida, Satoshi, Yamashiki, Yosuke Alexandre, Shimamura, Teppei

“…Establishing a sustainable life-support system for space exploration is a formidable challenge due to the vast distances, high costs, and environmental…”
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Excessive Hypoxia-Inducible Factor-1α Expression Induces Cardiac Rupture via p53-Dependent Apoptosis After Myocardial Infarction by Ikeda, Masataka, Ide, Tomomi, Tadokoro, Tomonori, Miyamoto, Hiroko Deguchi, Ikeda, Soichiro, Okabe, Kosuke, Ishikita, Akihito, Sato, Midori, Abe, Ko, Furusawa, Shun, Ishimaru, Kosei, Matsushima, Shouji, Tsutsui, Hiroyuki

“…Background Apoptosis plays a pivotal role in cardiac rupture after myocardial infarction (MI), and p53 is a key molecule in apoptosis during cardiac rupture…”
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Heart Rate Reduction with Ivabradine Prevents Cardiac Rupture after Myocardial Infarction in Mice by Ikeda, Masataka, Ide, Tomomi, Furusawa, Shun, Ishimaru, Kosei, Tadokoro, Tomonori, Miyamoto, Hiroko Deguchi, Ikeda, Soichiro, Okabe, Kosuke, Ishikita, Akihito, Abe, Ko, Matsushima, Shouji, Tsutsui, Hiroyuki

“…Purpose Cardiac rupture is a fatal complication following myocardial infarction (MI). An increase in heart rate (HR) is reportedly an independent risk factor…”
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Acute Myeloid Leukemia Harboring the t(16;21)(p11;q22) Translocation Treated With Venetoclax Plus Azacitidine After Cord Blood Transplantation by Teshima, Kazuaki, Ikeda, Sho, Abe, Ko, Yamada, Masahiro, Takahashi, Naoto

“…A 62-year-old female was diagnosed with acute myeloid leukemia (AML) with t(16;21)(p11;q22). She achieved complete hematological remission after induction…”
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