Search Results - "Abe, Kazuhiro"

Two-Dimensional Crystallization of Gastric H(+),K(+)-ATPase for Structural Analysis by Electron Crystallography by Abe, Kazuhiro

“…Electron crystallography of two-dimensional (2D) crystals has provided important information on the structural biology of P-type ATPases. Here, I describe the…”
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Crystal structure of a human plasma membrane phospholipid flippase by Nakanishi, Hanayo, Irie, Katsumasa, Segawa, Katsumori, Hasegawa, Kazuya, Fujiyoshi, Yoshinori, Nagata, Shigekazu, Abe, Kazuhiro

“…ATP11C, a member of the P4-ATPase flippase, translocates phosphatidylserine from the outer to the inner plasma membrane leaflet, and maintains the asymmetric…”
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Trends in hospitalizations for asthma during the COVID-19 outbreak in Japan by Abe, Kazuhiro, Miyawaki, Atsushi, Nakamura, Masaki, Ninomiya, Hideki, Kobayashi, Yasuki

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Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore by Urbani, Andrea, Giorgio, Valentina, Carrer, Andrea, Franchin, Cinzia, Arrigoni, Giorgio, Jiko, Chimari, Abe, Kazuhiro, Maeda, Shintaro, Shinzawa-Itoh, Kyoko, Bogers, Janna F. M., McMillan, Duncan G. G., Gerle, Christoph, Szabò, Ildikò, Bernardi, Paolo

“…The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By…”
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Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM by Nakanishi, Hanayo, Nishizawa, Tomohiro, Segawa, Katsumori, Nureki, Osamu, Fujiyoshi, Yoshinori, Nagata, Shigekazu, Abe, Kazuhiro

“…ATP11C, a plasma membrane phospholipid flippase, maintains the asymmetric distribution of phosphatidylserine accumulated in the inner leaflet…”
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Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2 by Nakanishi, Hanayo, Hayashida, Kenichi, Nishizawa, Tomohiro, Oshima, Atsunori, Abe, Kazuhiro

“…ATP11C is a member of the P4-ATPase flippase family that mediates translocation of phosphatidylserine (PtdSer) across the lipid bilayer. In order to…”
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Epidemiology of Food Choking Deaths in Japan: Time Trends and Regional Variations by Taniguchi, Yuta, Iwagami, Masao, Sakata, Nobuo, Watanabe, Taeko, Abe, Kazuhiro, Tamiya, Nanako

“…Background: With increasing age globally, more people may become vulnerable to food choking. We investigated the nationwide epidemiology of food choking deaths…”
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Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations by Abe, Kazuhiro, Yamamoto, Kenta, Irie, Katsumasa, Nishizawa, Tomohiro, Oshima, Atsunori

“…The gastric H + ,K + -ATPase mediates electroneutral exchange of 1H + /1K + per ATP hydrolysed across the membrane. Previous structural analysis of the K +…”
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Characteristics of first-time users of the nursing small-scale multifunctional home care service: a pooled cross-sectional study using Japanese long-term care insurance claims data from 2012 to 2019 by Morioka, Noriko, Kashiwagi, Masayo, Kashiwagi, Kimikazu, Abe, Kazuhiro, Miyawaki, Atsushi

“…ObjectivesIn April 2012, the Japanese government launched a new nursing service called the nursing small-scale multifunctional home care (NSMHC) to meet the…”
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Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms by Young, Victoria C., Nakanishi, Hanayo, Meyer, Dylan J., Nishizawa, Tomohiro, Oshima, Atsunori, Artigas, Pablo, Abe, Kazuhiro

“…Ion-transport mechanisms evolve by changing ion-selectivity, such as switching from Na + to H + selectivity in secondary-active transporters or P-type-ATPases…”
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Building primary care in Japan: Literature review by Kato, Daisuke, Ryu, Hikohaku, Matsumoto, Tomoki, Abe, Kazuhiro, Kaneko, Makoto, Ko, Mezhen, Irving, Greg, Ramsay, Robin, Kondo, Masatoshi

“…Japan's health system is well known for achieving one of the world's highest life expectancy with universal health coverage. However, the country now faces…”
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Human F-ATP synthase as a drug target by Gerle, Christoph, Jiko, Chimari, Nakano, Atsuki, Yokoyama, Ken, Gopalasingam, Chai C., Shigematsu, Hideki, Abe, Kazuhiro

“…Practical and conceptual barriers have kept human F-ATP synthase out of reach as a target for the treatment of human diseases. Although this situation has…”
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Isoform-selective regulation of mammalian cryptochromes by Miller, Simon, Son, You Lee, Aikawa, Yoshiki, Makino, Eri, Nagai, Yoshiko, Srivastava, Ashutosh, Oshima, Tsuyoshi, Sugiyama, Akiko, Hara, Aya, Abe, Kazuhiro, Hirata, Kunio, Oishi, Shinya, Hagihara, Shinya, Sato, Ayato, Tama, Florence, Itami, Kenichiro, Kay, Steve A., Hatori, Megumi, Hirota, Tsuyoshi

“…CRY1 and CRY2 are essential components of the circadian clock controlling daily physiological rhythms. Accumulating evidences indicate distinct roles of these…”
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Conformational rearrangement of gastric H + ,K + -ATPase induced by an acid suppressant by Fujiyoshi, Yoshinori, Abe, Kazuhiro, Tani, Kazutoshi

“…Acid-related gastric diseases are associated with disorder of digestive tract acidification. The gastric proton pump, H + ,K + -ATPase, exports H + in exchange…”
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167Epidemiology of food choking deaths in Japan: Time trends and regional variations by Taniguchi, Yuta, Iwagami, Masao, Sakata, Nobuo, Watanabe, Taeko, Abe, Kazuhiro, Tamiya, Nanako

“…Abstract Background We aimed to investigate the nationwide epidemiology of food choking deaths in Japan. Methods Using Japan Vital Statistics death data…”
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Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump by Tanaka, Saki, Morita, Mikio, Yamagishi, Tatsuya, Madapally, Hridya Valia, Hayashida, Kenichi, Khandelia, Himanshu, Gerle, Christoph, Shigematsu, Hideki, Oshima, Atsunori, Abe, Kazuhiro

“…As specific inhibitors of the gastric proton pump, responsible for gastric acidification, K+-competitive acid blockers (P-CABs) have recently been utilized in…”
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Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle by Abe, Kazuhiro, Tani, Kazutoshi, Nishizawa, Tomohiro, Fujiyoshi, Yoshinori

“…The gastric H + ,K + ‐ATPase is an ATP‐driven proton pump responsible for generating a million‐fold proton gradient across the gastric membrane. We present the…”
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Isolation of H(+),K(+)-ATPase-enriched Membrane Fraction from Pig Stomachs by Abe, Kazuhiro, Olesen, Claus

“…Gastric H(+),K(+)-ATPase is an ATP-driven proton pump responsible for the acid secretion. Here, we describe the procedure for the isolation of…”
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Cryo-EM structure of gastric H⁺,K⁺-ATPase with a single occupied cation-binding site by Abe, Kazuhiro, Tani, Kazutoshi, Friedrich, Thomas, Fujiyoshi, Yoshinori

“…Gastric H ⁺,K ⁺-ATPase is responsible for gastric acid secretion. ATP-driven H ⁺ uptake into the stomach is efficiently accomplished by the exchange of an…”
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Municipal long‐term care workforce supply and in‐home deaths at the end of life: Panel data analysis with a fixed‐effect model in Japan by Abe, Kazuhiro, Taniguchi, Yuta, Kawachi, Ichiro, Watanabe, Taeko, Tamiya, Nanako

“…Aim The study assessed the association between boosting the workforce supply by types of long‐term care services and in‐home deaths among older people at the…”
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