Search Results - "Abdurrob, Fatema"

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes by Raja, Waseem K, Mungenast, Alison E, Lin, Yuan-Ta, Ko, Tak, Abdurrob, Fatema, Seo, Jinsoo, Tsai, Li-Huei

“…The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to develop model systems of AD pathology that have higher predictive…”
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Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition by Martorell, Anthony J., Paulson, Abigail L., Suk, Ho-Jun, Abdurrob, Fatema, Drummond, Gabrielle T., Guan, Webster, Young, Jennie Z., Kim, David Nam-Woo, Kritskiy, Oleg, Barker, Scarlett J., Mangena, Vamsi, Prince, Stephanie M., Brown, Emery N., Chung, Kwanghun, Boyden, Edward S., Singer, Annabelle C., Tsai, Li-Huei

“…We previously reported that inducing gamma oscillations with a non-invasive light flicker (gamma entrainment using sensory stimulus or GENUS) impacted…”
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Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load by Singer, Annabelle C., Martorell, Anthony J., Douglas, J. Miller, Abdurrob, Fatema, Attokaren, Matthew K., Tipton, John, Mathys, Hansruedi, Adaikkan, Chinnakkaruppan, Tsai, Li-Huei

“…Microglia, the primary immune cells of the brain, play a key role in pathological and normal brain function. Growing efforts aim to reveal how these cells may…”
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Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice by Rodrigues-Amorim, Daniela, Bozzelli, P. Lorenzo, Kim, TaeHyun, Liu, Liwang, Gibson, Oliver, Yang, Cheng-Yi, Murdock, Mitchell H., Galiana-Melendez, Fabiola, Schatz, Brooke, Davison, Alexis, Islam, Md Rezaul, Shin Park, Dong, Raju, Ravikiran M., Abdurrob, Fatema, Nelson, Alissa J., Min Ren, Jian, Yang, Vicky, Stokes, Matthew P., Tsai, Li-Huei

“…Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes…”
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3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice by Gail Canter, Rebecca, Huang, Wen-Chin, Choi, Heejin, Wang, Jun, Ashley Watson, Lauren, Yao, Christine G., Abdurrob, Fatema, Bousleiman, Stephanie M., Young, Jennie Z., Bennett, David A., Delalle, Ivana, Chung, Kwanghun, Tsai, Li-Huei

“…Alzheimer’s disease (AD) is a progressive, neurodegenerative dementia with no cure. Prominent hypotheses suggest accumulation of beta-amyloid (Aβ) contributes…”
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Single-cell transcriptomic analysis of Alzheimer’s disease by Mathys, Hansruedi, Davila-Velderrain, Jose, Peng, Zhuyu, Gao, Fan, Mohammadi, Shahin, Young, Jennie Z., Menon, Madhvi, He, Liang, Abdurrob, Fatema, Jiang, Xueqiao, Martorell, Anthony J., Ransohoff, Richard M., Hafler, Brian P., Bennett, David A., Kellis, Manolis, Tsai, Li-Huei

“…Alzheimer’s disease is a pervasive neurodegenerative disorder, the molecular complexity of which remains poorly understood. Here, we analysed 80,660…”
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Gamma frequency entrainment attenuates amyloid load and modifies microglia by Iaccarino, Hannah F., Singer, Annabelle C., Martorell, Anthony J., Rudenko, Andrii, Gao, Fan, Gillingham, Tyler Z., Mathys, Hansruedi, Seo, Jinsoo, Kritskiy, Oleg, Abdurrob, Fatema, Adaikkan, Chinnakkaruppan, Canter, Rebecca G., Rueda, Richard, Brown, Emery N., Boyden, Edward S., Tsai, Li-Huei

“…Changes in gamma oscillations (20–50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and…”
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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types by Lin, Yuan-Ta, Seo, Jinsoo, Gao, Fan, Feldman, Heather M., Wen, Hsin-Lan, Penney, Jay, Cam, Hugh P., Gjoneska, Elizabeta, Raja, Waseem K., Cheng, Jemmie, Rueda, Richard, Kritskiy, Oleg, Abdurrob, Fatema, Peng, Zhuyu, Milo, Blerta, Yu, Chung Jong, Elmsaouri, Sara, Dey, Dilip, Ko, Tak, Yankner, Bruce A., Tsai, Li-Huei

“…The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzheimer’s disease (sAD). However, the cell-type-specific…”
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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types by Lin, Yuan-Ta, Seo, Jinsoo, Gao, Fan, Feldman, Heather M., Wen, Hsin-Lan, Penney, Jay, Cam, Hugh P., Gjoneska, Elizabeta, Raja, Waseem K., Cheng, Jemmie, Rueda, Richard, Kritskiy, Oleg, Abdurrob, Fatema, Peng, Zhuyu, Milo, Blerta, Yu, Chung Jong, Elmsaouri, Sara, Dey, Dilip, Ko, Tak, Yankner, Bruce A., Tsai, Li-Huei

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Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors by Meharena, Hiruy S., Marco, Asaf, Dileep, Vishnu, Lockshin, Elana R., Akatsu, Grace Y., Mullahoo, James, Watson, L. Ashley, Ko, Tak, Guerin, Lindsey N., Abdurrob, Fatema, Rengarajan, Shruthi, Papanastasiou, Malvina, Jaffe, Jacob D., Tsai, Li-Huei

“…Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21) and characterized by a wide range of neurodevelopmental and physical…”
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MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration by Barker, Scarlett J, Raju, Ravikiran M, Milman, Noah E P, Wang, Jun, Davila-Velderrain, Jose, Gunter-Rahman, Fatima, Parro, Cameron C, Bozzelli, P Lorenzo, Abdurrob, Fatema, Abdelaal, Karim, Bennett, David A, Kellis, Manolis, Tsai, Li-Huei

“…Recent increases in human longevity have been accompanied by a rise in the incidence of dementia, highlighting the need to preserve cognitive function in an…”
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Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer's disease by Huang, Wen-Chin, Peng, Zhuyu, Murdock, Mitchell H, Liu, Liwang, Mathys, Hansruedi, Davila-Velderrain, Jose, Jiang, Xueqiao, Chen, Maggie, Ng, Ayesha P, Kim, TaeHyun, Abdurrob, Fatema, Gao, Fan, Bennett, David A, Kellis, Manolis, Tsai, Li-Huei

“…The neural circuits governing the induction and progression of neurodegeneration and memory impairment in Alzheimer's disease (AD) are incompletely understood…”
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Author Correction: Single-cell transcriptomic analysis of Alzheimer’s disease by Mathys, Hansruedi, Davila-Velderrain, Jose, Peng, Zhuyu, Gao, Fan, Mohammadi, Shahin, Young, Jennie Z., Menon, Madhvi, He, Liang, Abdurrob, Fatema, Jiang, Xueqiao, Martorell, Anthony J., Ransohoff, Richard M., Hafler, Brian P., Bennett, David A., Kellis, Manolis, Tsai, Li-Huei

“…Change history: In this Article, the Acknowledgements section should have included that the work was supported in part by the Cure Alzheimer’s Fund (CAF), and…”
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Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia by Iaccarino, Hannah F., Singer, Annabelle C., Martorell, Anthony J., Rudenko, Andrii, Gao, Fan, Gillingham, Tyler Z., Mathys, Hansruedi, Seo, Jinsoo, Kritskiy, Oleg, Abdurrob, Fatema, Adaikkan, Chinnakkaruppan, Canter, Rebecca G., Rueda, Richard, Brown, Emery N., Boyden, Edward S., Tsai, Li-Huei

“…Change history: In this Article, Extended Data Fig. 8 and Extended Data Table 1 contained errors, which have been corrected online…”
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3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice by Gail Canter, Rebecca, Huang, Wen-Chin, Choi, Heejin, Wang, Jun, Ashley Watson, Lauren, Yao, Christine G, Abdurrob, Fatema, Bousleiman, Stephanie M, Young, Jennie Z, Bennett, David A, Delalle, Ivana, Chung, Kwanghun, Tsai, Li-Huei

“…Alzheimer's disease (AD) is a progressive, neurodegenerative dementia with no cure. Prominent hypotheses suggest accumulation of beta-amyloid (Aβ) contributes…”
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N- and C-terminal non-conserved residues contribute to transactivation by a sea anemone (Nematostella vectensis) NF-κB transcription factor by Alshanbayeva, Anar, Thomas, Ajith, Tremblay, Martine, Abbas, Majed, Abdurrob, Fatema, Almojel, Talal, Aparicio, Alexis, Asarpota, Dhishant, Ayers, Ashley, Aziz, Amar, Bishop, Jacob, Christie, Theresa, Chua, Ming Jie, Melissa, Chung, Oliver, Dhar, Nikhil, Diedrich, Alexa, Fortin, Chelsea, He, Qianjing, Heerboth, Sarah, Hok, Rosanna, Khedkar, Aditya, Kitchloo, Shweta, Lawlor, Caitlin, Leonard, Brian, Linderman, Shannon, Maloyan, Mariam, Miller, Lauren, Pak, Christine, Pandita, Abishy, Park, Isabel, Patel, Neil, Ramachandran, Janani, Reynoso, Marinaliz, Samaha, Yasmina, Thole, Grace, Turnbill, Jason, Xia, Linge, Zhu, Jingzhi, Navarro, Caryn, Gilmore, Thomas D

“…NF-κB is an evolutionarily conserved eukaryotic transcription factor that plays a role in many important developmental and immune-related processes by…”
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