Evaluating the antibacterial effect of cobalt nanoparticles against multi-drug resistant pathogens

This study aimed to estimate the effect of cobalt nanoparticles (Co NPs) with different concentrations against multidrug-resistant (MDR) pathogenic bacteria. Three isolates of (gram-positive), . (gram-negative), and (gram-negative) bacteria were extracted from various clinical examples utilizing rou...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of medicine and life Vol. 14; no. 6; pp. 823 - 833
Main Authors:	Abass, Abeer Abdulridha, Abdulridha, Wasna A Mohammed, Alaarage, Warood Kream, Abdulrudha, Noor Hassan, Haider, Julfikar
Format:	Journal Article
Language:	English
Published:	Romania Carol Daila University Foundation 01-11-2021 Carol Davila University Press
Subjects:	Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics Antimicrobial agents Bacteria Cobalt Cobalt - pharmacology Drug resistance E coli Gram-positive bacteria Humans Microbial Sensitivity Tests Multidrug resistance Nanoparticles Nanotechnology Nosocomial infections Original Pharmaceutical Preparations Pneumonia Staphylococcus aureus pathogenic bacteria Co NPs – Cobalt nanoparticles cobalt nanoparticle MH – Muller-Hinton agar medium SEM – Scanning Electron Microscope nanomedicine antimicrobial activity MDR – Multidrug-resistant antibiotics AI – Activity index XRD – X-Ray diffraction
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study aimed to estimate the effect of cobalt nanoparticles (Co NPs) with different concentrations against multidrug-resistant (MDR) pathogenic bacteria. Three isolates of (gram-positive), . (gram-negative), and (gram-negative) bacteria were extracted from various clinical examples utilizing routine methods on bacteriological culture media. The antibacterial sensitivity of commercial antibiotics such as Ciprofloxacin, Cefotaxime, Gentamycin, and Amoxicillin was broken down on a Muller Hinton agar plate and evaluated using the disk diffusion method. The study results demonstrated the antibacterial effect of the Co NPs against the bacterial isolates with three different concentrations utilized in the study. The results indicated that the Co NPs showed the highest antibacterial activity when utilizing 100 μg/ml against followed by and with zones of inhibition measured as 22.2±0.1 mm, 20.3±0.15 mm, and 15.8±0.1 mm; respectively. Co NPs at a 100 μg/mL concentration showed higher inhibition zones than several common antibiotics except for Ciprofloxacin, which demonstrated better antibacterial activity against the bacterial isolates employed in this study. Scanning Electron Microscope (SEM)and X-Ray diffraction (XRD)studies confirmed that Cobalt nanoparticles (Co NPs) were synthesized from cobalt sulphate solution with a size ranging from 40 nm to 60 nm. The nanoparticles showed a crystalline structure with a round shape and smooth surface. The antibacterial resistance of Co NPs against three common bacteria such as , , and was assessed in this study. The optimum concentration of the Co NPs was identified as 100 μg/ml, which could provide a similar or higher antibacterial effect.
ISSN:	1844-122X 1844-3117
DOI:	10.25122/jml-2021-0270