Search Results - "Abdulrahman Mujalli"
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Identification of miRNA–mRNA–TFs regulatory network and crucial pathways involved in asthma through advanced systems biology approaches
Published in PloS one (20-10-2022)“…Asthma is a life-threatening and chronic inflammatory lung disease that is posing a true global health challenge. The genetic basis of the disease is fairly…”
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2
Antibacterial Effects of Commiphora gileadensis Methanolic Extract on Wound Healing
Published in Molecules (Basel, Switzerland) (21-05-2022)“…Commiphora gileadensis (CG) is a small tree distributed throughout the Middle East. It was traditionally used in perfumes in countries in this area. In Saudi…”
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3
Key Disease-Related Genes and Immune Cell Infiltration Landscape in Inflammatory Bowel Disease: A Bioinformatics Investigation
Published in International journal of molecular sciences (01-09-2024)“…Inflammatory Bowel Diseases (IBD), which encompass ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation and tissue…”
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4
Bioinformatics insights into the genes and pathways on severe COVID-19 pathology in patients with comorbidities
Published in Frontiers in physiology (14-12-2022)“…Coronavirus disease (COVID-19) infection is known for its severe clinical pathogenesis among individuals with pre-existing comorbidities. However, the…”
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Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells
Published in Molecules (Basel, Switzerland) (01-12-2022)“…Natural antioxidants derived from plants have played a vital role in preventing a wide range of human chronic conditions and provide novel bioactive leads for…”
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Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus
Published in International journal of molecular sciences (12-12-2023)“…Herein, we measured the antidiabetic and nephroprotective effects of the sodium-glucose cotransporter-2 inhibitor (empagliflozin; SGLT2i) and synthetic active…”
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7
A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers
Published in Frontiers in genetics (16-11-2022)“…Background: Prostate cancer (PC) is a fatally aggressive urogenital cancer killing millions of men, globally. Thus, this study aims to identify key miRNAs,…”
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Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness
Published in Frontiers in endocrinology (Lausanne) (03-05-2023)“…Although estrogen (ERα/ERβ), progesterone (PGR), and androgen (AR) receptors are pathologically altered in colorectal cancer (CRC), their simultaneous…”
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9
Metabolite Alterations in Autoimmune Diseases: A Systematic Review of Metabolomics Studies
Published in Metabolites (01-09-2023)“…Autoimmune diseases, characterized by the immune system’s loss of self-tolerance, lack definitive diagnostic tests, necessitating the search for reliable…”
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10
Exploring the Role of PI3P in Platelets: Insights from a Novel External PI3P Pool
Published in Biomolecules (Basel, Switzerland) (24-03-2023)“…Phosphoinositides (PIs) play a crucial role in regulating intracellular signaling, actin cytoskeleton rearrangements, and membrane trafficking by binding to…”
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11
Molecular profiling of melanocortin 4 receptor variants and agouti-related peptide interactions in morbid obese phenotype: a novel paradigm from molecular docking and dynamics simulations
Published in Biológia (01-05-2022)“…MC4R is a G protein-coupled receptor that regulates energy homeostasis through the leptin-melanocortin pathway. MC4R genetic defects are a known cause of…”
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12
Potential Biomarkers for Parkinson Disease from Functional Enrichment and Bioinformatic Analysis of Global Gene Expression Patterns of Blood and Substantia Nigra Tissues
Published in Bioinformatics and biology insights (01-01-2023)“…The Parkinson disease (PD) is the second most common neurodegenerative disorder affecting the central nervous system and motor functions. The biological…”
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13
The Quality of Blood Donation Services and Its Association with Blood Donors' Trust and Loyalty at Makkah Blood Donation Centers in Saudi Arabia: A Cross-Sectional Study
Published in Healthcare (Basel) (25-07-2023)“…The current cross-sectional study was conducted to determine the quality of blood donation services and its association with blood donors' trust and loyalty at…”
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14
Exome Sequencing Identifies the Extremely Rare ITGAV and FN1 Variants in Early Onset Inflammatory Bowel Disease Patients
Published in Frontiers in pediatrics (26-05-2022)“…Molecular diagnosis of early onset inflammatory bowel disease (IBD) is very important for adopting suitable treatment strategies. Owing to the sparse data…”
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15
Myocardial infarction biomarker discovery with integrated gene expression, pathways and biological networks analysis
Published in Genomics (San Diego, Calif.) (01-11-2020)“…Myocardial infarction (MI) is the most prevalent coronary heart disease caused by the complex molecular interactions between multiple genes and environment…”
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Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01-09-2018)“…Phosphoinositides are bioactive lipids essential in the regulation of cell signaling as well as cytoskeleton and membrane dynamics. Their metabolism is highly…”
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Phosphoinositides: Important lipids in the coordination of cell dynamics
Published in Biochimie (01-06-2016)“…By interacting specifically with proteins, phosphoinositides organize the spatiotemporal formation of protein complexes involved in the control of…”
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18
Lack of association of ABO and RhD blood groups with COVID-19 mortality: A 2-center cross-sectional study in Saudi Arabia
Published in Medicine (Baltimore) (13-09-2024)“…Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous…”
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Relationship of Vitamin-D Deficiency with Kidney Disease in Patients with Type-2 Diabetes Mellitus
Published in Diabetes, metabolic syndrome and obesity (31-01-2024)“…Aim: Vitamin D deficiency is linked with type 2 diabetes mellitus (T2DM) and the occurrence of complications in patients with type 2 diabetes mellitus. None of…”
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Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat
Published in Journal of trace elements in medicine and biology (01-09-2023)“…Cadmium (Cd) is a major environmental pollutant and chronic toxicity could induce nephropathy by increasing renal oxidative stress and inflammation. Although…”
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