Search Results - "Abdulrahman, Basant A."

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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Autophagy pathways in the treatment of prion diseases by Abdelaziz, Dalia H, Abdulrahman, Basant A, Gilch, Sabine, Schatzl, Hermann M

“…•Prions are misfolded proteins causing fatal neurodegenerative diseases.•Autophagy dictates the fate of PrPSc in various contexts in prion infection.•Autophagy…”
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Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model by Thapa, Simrika, Abdelaziz, Dalia H., Abdulrahman, Basant A., Schatzl, Hermann M.

“…Prion diseases are fatal infectious neurodegenerative disorders in human and animals caused by misfolding of the cellular prion protein (PrP C ) into the…”
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Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Abdelaziz, Dalia H.A., Newland, Christie, Rosales-Reyes, Roberto, Kopp, Benjamin, McCoy, Karen, Montione, Richard, Schlesinger, Larry S., Gavrilin, Mikhail A., Wewers, Mark D., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis (CF) is the most common inherited lethal disease of Caucasians which results in multi organ dysfunction. However, 85% of the deaths are due to…”
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Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia by Gavrilin, Mikhail A, Abdelaziz, Dalia H A, Mostafa, Mahmoud, Abdulrahman, Basant A, Grandhi, Jaykumar, Akhter, Anwari, Abu Khweek, Arwa, Aubert, Daniel F, Valvano, Miguel A, Wewers, Mark D, Amer, Amal O

“…Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis…”
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The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions by Abdulrahman, Basant A., Abdelaziz, Dalia, Thapa, Simrika, Lu, Li, Jain, Shubha, Gilch, Sabine, Proniuk, Stefan, Zukiwski, Alexander, Schatzl, Hermann M.

“…Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein…”
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Combining autophagy stimulators and cellulose ethers for therapy against prion disease by Abdulrahman, Basant A., Tahir, Waqas, Doh-Ura, Katsumi, Gilch, Sabine, Schatzl, Hermann M.

“…Prion diseases are fatal transmissible neurodegenerative disorders that affect animals and humans. Prions are proteinaceous infectious particles consisting of…”
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A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy by Khweek, Arwa A., Caution, Kyle, Akhter, Anwari, Abdulrahman, Basant A., Tazi, Mia, Hassan, Hoda, Majumdar, Neal, Doran, Andrew, Guirado, Evelyn, Schlesinger, Larry S., Shuman, Howard, Amer, Amal O.

“…Legionella pneumophila (L. pneumophila) is an intracellular bacterium of human alveolar macrophages that causes Legionnaires’ disease. In contrast to humans,…”
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Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes by Abdelaziz, Dalia H., Gavrilin, Mikhail A., Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Khweek, Arwa Abu, Abdulrahman, Basant A., Grandhi, Jaykumar, Hassan, Zeinab A., Marsh, Clay, Wewers, Mark D., Amer, Amal O.

“…The ability of Legionella pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their…”
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Autophagy regulates exosomal release of prions in neuronal cells by Abdulrahman, Basant A., Abdelaziz, Dalia H., Schatzl, Hermann M.

“…Prions are protein-based infectious agents that autocatalytically convert the cellular prion protein PrPC to its pathological isoform PrPSc. Subsequent…”
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Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages by Abdelaziz, Dalia H A, Gavrilin, Mikhail A, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Khweek, Arwa Abu, Abdulrahman, Basant A, Hassan, Zeinab A, El-Sharkawi, Fathia Z, Bedi, Simranjit S, Ladner, Katherine, Gonzalez-Mejia, M Elba, Doseff, Andrea I, Mostafa, Mahmoud, Kanneganti, Thirumala-Devi, Guttridge, Dennis, Marsh, Clay B, Wewers, Mark D, Amer, Amal O

“…The apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) is an adaptor molecule that mediates inflammatory and apoptotic…”
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Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Tazi, Mia, Hassan, Hoda, Zhang, Yucheng, Rowland, Patrick D., Malhotra, Sankalp, Aeffner, Famke, Davis, Ian C., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator…”
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Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients by Kopp, Benjamin T., Abdulrahman, Basant A., Khweek, Arwa A., Kumar, Surender B., Akhter, Anwari, Montione, Richard, Tazi, Mia F., Caution, Kyle, McCoy, Karen, Amer, Amal O.

“…► CF macrophages produce excess IL-1β, IL-10, MCP-1, and IFN-γ during Burkholderia cenocepacia infection. ► B. cenocepacia avoids lysosomal degradation in CF…”
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A bacterial protein promotes the recognition of the L egionella pneumophila vacuole by autophagy by Khweek, Arwa A., Caution, Kyle, Akhter, Anwari, Abdulrahman, Basant A., Tazi, Mia, Hassan, Hoda, Majumdar, Neal, Doran, Andrew, Guirado, Evelyn, Schlesinger, Larry S., Shuman, Howard, Amer, Amal O.

“…Legionella pneumophila ( L . pneumophila ) is an intracellular bacterium of human alveolar macrophages that causes Legionnaires’ disease. In contrast to…”
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Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages by Abu Khweek, Arwa, Fernández Dávila, Natalia S, Caution, Kyle, Akhter, Anwari, Abdulrahman, Basant A, Tazi, Mia, Hassan, Hoda, Novotny, Laura A, Bakaletz, Lauren O, Amer, Amal O

“…Legionella pneumophila, the causative agent of Legionnaire's disease, replicates in human alveolar macrophages to establish infection. There is no…”
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EXAGGERATED INFLAMMATORY RESPONSES MEDIATED BY BURKHOLDERIA CENOCEPACIA IN HUMAN MACROPHAGES DERIVED FROM CYSTIC FIBROSIS by Kopp, Benjamin T., Abdulrahman, Basant A., Khweek, Arwa A., Kumar, Surender B., Akhter, Anwari, Montione, Richard, Tazi, Mia F., Caution, Kyle, McCoy, Karen, Amer, Amal O.

“…Cystic Fibrosis (CF) is accompanied with heightened inflammation worsened by drug resistant Burkholderia cenocepacia . Human CF macrophage responses to B…”
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Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes<inline-graphic xlink:href="sbox.jpg"/> by Abdelaziz, Dalia H, Gavrilin, Mikhail A, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Khweek, Arwa Abu, Abdulrahman, Basant A, Grandhi, Jaykumar, Hassan, Zeinab A, Marsh, Clay, Wewers, Mark D, Amer, Amal O

“…The ability of Legionella pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their…”
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