Search Results - "Abdulmughni, Ammar"

Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium by Jóźwik, Ilona K., Kiss, Flora M., Gricman, Łukasz, Abdulmughni, Ammar, Brill, Elisa, Zapp, Josef, Pleiss, Juergen, Bernhardt, Rita, Thunnissen, Andy‐Mark W. H.

“…Cytochrome P450 monooxygenases (P450s) are attractive enzymes for the pharmaceutical industry, in particular, for applications in steroidal drug synthesis…”
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Biochemical and structural characterization of CYP109A2, a vitamin D3 25‐hydroxylase from Bacillus megaterium by Abdulmughni, Ammar, Jóźwik, Ilona K., Brill, Elisa, Hannemann, Frank, Thunnissen, Andy‐Mark W. H., Bernhardt, Rita

“…Cytochrome P450 enzymes are increasingly investigated due to their potential application as biocatalysts with high regio‐ and/or stereo‐selectivity and under…”
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Improvement of the 25-hydroxyvitamin D3 production in a CYP109A2-expressing Bacillus megaterium system by Abdulmughni, Ammar, Erichsen, Björn, Hensel, Jürgen, Hannemann, Frank, Bernhardt, Rita

“…•Demonstrating the importance of the region between amino acids T103-A106 of CYP109A2 for the hydroxylation of vitamin D3.•Increasing the productivity of…”
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Improvement of the 25-hydroxyvitamin D 3 production in a CYP109A2-expressing Bacillus megaterium system by Abdulmughni, Ammar, Erichsen, Björn, Hensel, Jürgen, Hannemann, Frank, Bernhardt, Rita

“…Calcifediol (25(OH)VD3) is a physiologically very important vitamin D metabolite and of high pharmaceutical importance, due to its potential for treating not…”
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CYP109E1 is a novel versatile statin and terpene oxidase from Bacillus megaterium by Putkaradze, Natalia, Litzenburger, Martin, Abdulmughni, Ammar, Milhim, Mohammed, Brill, Elisa, Hannemann, Frank, Bernhardt, Rita

“…CYP109E1 is a cytochrome P450 monooxygenase from Bacillus megaterium with a hydroxylation activity for testosterone and vitamin D3. This study reports the…”
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Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling by Jóźwik, Ilona K, Bombino, Elvira, Abdulmughni, Ammar, Hartz, Philip, Rozeboom, Henriette J, Wijma, Hein J, Kappl, Reinhard, Janssen, Dick B, Bernhardt, Rita, Thunnissen, Andy-Mark W H

“…The P450 monooxygenase CYP109A2 from Bacillus megaterium DSM319 was previously found to convert vitamin D3 (VD3) to 25-hydroxyvitamin D3. Here, we show that…”
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Resurrection and characterization of ancestral CYP11A1 enzymes by Hartz, Philip, Strohmaier, Silja J., EL‐Gayar, Basma M., Abdulmughni, Ammar, Hutter, Michael C., Hannemann, Frank, Gillam, Elizabeth M. J., Bernhardt, Rita

“…Mitochondrial cytochromes P450 presumably originated from a common microsomal P450 ancestor. However, it is still unknown how ancient mitochondrial P450s were…”
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Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin by Milhim, Mohammed, Putkaradze, Natalia, Abdulmughni, Ammar, Kern, Fredy, Hartz, Philip, Bernhardt, Rita

“…•Identification and characterization of new plasmid-encoded cytochrome P450 from Bacillus megaterium.•The new cytochrome P450 belongs to the CYP107 family and…”
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Biochemical and structural characterization of CYP109A2, a vitamin D 3 25-hydroxylase from Bacillus megaterium by Abdulmughni, Ammar, Jóźwik, Ilona K, Brill, Elisa, Hannemann, Frank, Thunnissen, Andy-Mark W H, Bernhardt, Rita

“…Cytochrome P450 enzymes are increasingly investigated due to their potential application as biocatalysts with high regio- and/or stereo-selectivity and under…”
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Biochemical and structural characterization of CYP 109A2, a vitamin D 3 25‐hydroxylase from Bacillus megaterium by Abdulmughni, Ammar, Jóźwik, Ilona K., Brill, Elisa, Hannemann, Frank, Thunnissen, Andy‐Mark W. H., Bernhardt, Rita

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Characterization of cytochrome P450 CYP109E1 from Bacillus megaterium as a novel vitamin D 3 hydroxylase by Abdulmughni, Ammar, Jóźwik, Ilona K, Putkaradze, Natalia, Brill, Elisa, Zapp, Josef, Thunnissen, Andy-Mark W H, Hannemann, Frank, Bernhardt, Rita

“…In this study the ability of CYP109E1 from Bacillus megaterium to metabolize vitamin D (VD ) was investigated. In an in vitro system using bovine adrenodoxin…”
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Conserved Gating Elements in TRPC4 and TRPC5 Channels by Beck, Andreas, Speicher, Tilman, Stoerger, Christof, Sell, Thomas, Dettmer, Viviane, Jusoh, Siti A., Abdulmughni, Ammar, Cavalié, Adolfo, Philipp, Stephan E., Zhu, Michael X., Helms, Volkhard, Wissenbach, Ulrich, Flockerzi, Veit

“…TRPC4 and TRPC5 proteins share 65% amino acid sequence identity and form Ca2+-permeable nonselective cation channels. They are activated by stimulation of…”
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Characterization of cytochrome P450 CYP109E1 from Bacillus megaterium as a novel vitamin D3 hydroxylase by Abdulmughni, Ammar, Jóźwik, Ilona K., Putkaradze, Natalia, Brill, Elisa, Zapp, Josef, Thunnissen, Andy-Mark W.H., Hannemann, Frank, Bernhardt, Rita

“…•CYP109E1 from Bacillus megaterium has a 25- and 24-hydroxylation activity towards vitamin D3.•A CYP109E1 based whole-cell system for the conversion of vitamin…”
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Structural basis of steroid binding and oxidation by the cytochrome P450 CYP 109E1 from Bacillus megaterium by Jóźwik, Ilona K., Kiss, Flora M., Gricman, Łukasz, Abdulmughni, Ammar, Brill, Elisa, Zapp, Josef, Pleiss, Juergen, Bernhardt, Rita, Thunnissen, Andy‐Mark W. H.

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